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Jawad, M. A, Kadhim, A. J, Hasan, S. Y. (1400). Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice. سامانه مدیریت نشریات علمی, 76(5), 1561-1564. doi: 10.22092/ari.2021.356080.1773
M. A Jawad; A. J Kadhim; S. Y Hasan. "Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1561-1564. doi: 10.22092/ari.2021.356080.1773
Jawad, M. A, Kadhim, A. J, Hasan, S. Y. (1400). 'Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice', سامانه مدیریت نشریات علمی, 76(5), pp. 1561-1564. doi: 10.22092/ari.2021.356080.1773
Jawad, M. A, Kadhim, A. J, Hasan, S. Y. Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice. سامانه مدیریت نشریات علمی, 1400; 76(5): 1561-1564. doi: 10.22092/ari.2021.356080.1773

Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice

Archives of Razi Institute
مقاله 47، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1561-1564    اصل مقاله (449.64 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22092/ari.2021.356080.1773
نویسندگان
M. A Jawad* 1؛ A. J Kadhim1؛ S. Y Hasan2
1Al-Nisour University College, Baghdad, Iraq
2National University for Science And Technology, Nasiriyah, Iraq
چکیده
Traditional medicine has been long used to prevent and/or treat diseases worldwide based on a wealth of experiences, principles, and beliefs in different cultures. Among the extracts used in traditional medicine, we can refer to the aqueous beetle cocoon extract of Larinus maculates popularly known as Tihan in Iraq. To determine the histological effect of this extract on mice liver tissue, the animals were assigned to four groups (n=5) treated with (150,200,400) mg/kg of Cocoon aqueous extract of Larinus maculates for 14 days, respectively. Histology and immunohistochemistry test was performed to evaluate changes in liver tissue and tumor necrosis factor alpha (TNF-α) levels.The results showed various pathological dose-depended changes in the liver tissue, including infiltrations, congestion, and vacuolation, along with some dead cells; moreover, necrotic hepatocytes were observed in the liver of highly concentrated treatment group (400 mg kg-1). In addition, the TNF-α level in the liver tissue was elevated by the increased concentration of the extract. The immunohistochemistry result of positive reaction to TNF-α revealed high reaction in the liver tissue of mice treated with 200 mg kg-1 and 400 mg kg-1, as compared to the control group. Furthermore, as evidenced by the obtained results, changes in hepatocytes and the severity of pathological changes in the liver depends on the concentration of the extract of Larinus maculates.
کلیدواژه‌ها
Larinus maculates؛ Histological changes؛ Liver؛ Male mice
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مراجع
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