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Therapeutic Effect of Exosomes Derived From Bone Marrow Mesenchymal Stem Cells on Lingual Papillae Mucositis Induced by 5-fluorouracil in Albino Rats | ||
| Archives of Razi Institute | ||
| مقاله 27، دوره 81، شماره 2، خرداد و تیر 2026، صفحه 515-524 اصل مقاله (3.38 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.32598/ARI.81.2.3900 | ||
| نویسندگان | ||
| Sara Mostafa Shogaa* 1؛ Enas Mahmoud Hegazy2؛ Mahmoud Al Ankily1؛ Rania Abdelazeim Galhom3؛ Elham Fathy Mahmoud2 | ||
| 1Department of Oral Biology, The British University in Egypt, Cairo, Egypt | ||
| 2Department of Oral biology, Suez Canal University, Ismailia, Egypt | ||
| 3Department of Human Anatomy and Embryology, Suez Canal University, Ismailia, Egypt. | ||
| چکیده | ||
| Introduction: 5-fluorouracil (5-FU) is one of the prevalent anti-cancer drugs that is commonly used in chemotherapeutic modalities to treat head and neck solid cancers. However, various studies have reported that 5-FU has the ability to generate toxicity in different tissues, causing oral mucositis. Using exosomes derived from stem cells is gaining huge attention for therapies, as it may have certain advantages over adult stem cell-based therapies. This study aimed to evaluate the therapeutic effect of bone marrow-derived stem cells exosomes on the cytotoxicity induced by 5-FU on the lingual papillae of albino rats. Materials & Methods: Thirty male albino rats weighing between 150-200 grams were equally and randomly divided into 3 groups as follows: Group I (control group): containing 10 rats, received saline daily via oral gavage for 14 days. Group II (5-FU group): containing 10 rats, received a single intraperitoneal (IP) injection of 5-FU® drug (50 mg/kg) each. Group III (5-FU + exosomes group): containing 10 rats; the rats was treated as group II, then received a single injection of exosomes through the tail vein day 2 (100 μg/kg/dose suspended in 0.2 mL PBS). Rats of each group were euthanized after 14 days, and tongue specimens were collected for histological, ultrastructural, and immunohistochemical evaluation. Results: In the 5-FU treated group, there were marked degenerative changes of the filiform papillae, such as areas of keratin separation and hyperkeratinization and the fungiform papillae showed atrophy and deformed taste buds. The exosomes-treated group, however, showed marked improvement in histological, ultrastructural, and immunohistochemical findings. Conclusion: Exosomes derived from bone marrow mesenchymal stem cells (MSCs) exerted an obvious therapeutic effect against the induced mucositis caused by the cytotoxic effect of 5-FU, as reflected in improved histological, ultrastructural, and immunohistochemical findings. | ||
| کلیدواژهها | ||
| 5-Fluorouracil؛ BAX؛ Exosomes؛ Mesenchymal stem cells derived exosomes؛ Oral Mucositis (OM) | ||
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آمار تعداد مشاهده مقاله: 83 تعداد دریافت فایل اصل مقاله: 148 |
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