1Department of Pediatrics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Student Research committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3Department of Emergency Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
4Department of Infectious Diseases, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
5Department of Medical Laboratory Science, College of Science, Knowledge University, kirkuk Road, Erbil 44001, Iraq
6Department of Anatomical Sciences, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
7Department of Microbiology, Faculty of Sciences, Urmia Branch Islamic Azad University, Urmia, Iran
8Department of Biology-Plant Physiology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran
9Department of Community Medicine, School of Medicine Pediatric Gastroenterology and Hepatology Research Center Amir al Momenin Hospital, Zabol University of Medical Sciences
چکیده
In recent years, the resistance of bacterial strains has been increasing, and effective treatment has decreased. For this purpose, researchers are looking for nanoparticles with antibacterial properties. In this experimental study, the aqueous extract of Capparis is combined with 0.1 M zinc sulfate solution to form zinc nanoparticles. The average diameter of the nanoparticles is measured by X-ray diffraction and Scanning Electron Microscopy (SEM). Then, the diameter of the inhibitory zone and the minimum inhibitory concentration against the bacterial strains are determined. The results of the study showed that the largest diameter of the inhibition zone at a concentration of 1500 μg/ml was 23 mm, and the smallest diameter of the inhibition zone at the same concentration was 7 mm. The lowest inhibitory concentration at a concentration of 750 μg/ml was 4 mm, while the largest diameter of the inhibition zone at a concentration of 750 μg/ml was 19 mm. The results of this study showed that there is a direct relationship between the concentration of nanoparticles and the elimination of bacteria, meaning that increasing the concentration of zinc nanoparticles increases the rate of bacterial killing.
Gengenbacher M., Dick T. Antibacterial drug discovery: doing it right. Chemical Biology. 2015; 22(1): 5-6.
Atta A.M., Al -Lohedan H.A., Ezzat A.O. Synthesis of silver nanoparticles by green method stabilized to synthetic human stomach fluid. Molecules. 2014;19(5):6737-53.
Karimi J., Mohsenzadeh S. Plant synthesis of silver nanoparticles by Achilleawilhelmsii Pharmaceutical plant. Razi Journal of Medical Sciences. 2013;20(111):64- 9.
Srikar S.K., Giri D.D., Pal D.B., Mishra P.K., Upadhyay S.N. Green synthesis of silver nanoparticles: a review. Green and Sustainable Chemistry. 2016; 6(1): 34-56.
Xia Y. Nanomaterials at work in biomedical research. Nature Materials. 2008;7(10):758-60. [PubMed ID: 18813296]. https://doi.org/10.1038/nmat2277.
Ahmed S. A review on plants extract mediated synthesis of silver nanoparticles for antimicrobial applications: a green expertise. Journal of Advanced Research. 2016.
Mansoor S., Ullah I., Khan N. Diversity and antibiotic resistance profile analysis of uropathogenic bacteria in human and canines. Cellular, Molecular and Biomedical Reports. 2024;4(2):65-73. doi: https://doi.org/10.55705/cmbr.2023.411879.1169
Belete M.A., Saravanan M. A systematic review on drug resistant urinary tract infection among pregnant women in developing countries in Africa and Asia; 2005–2016. Infection and Drug Resistance. 2020;13:1465-77. doi: https://doi.org/10.2147/IDR.S250654
Litwin M.S., Saigal C.S., Yano E.M., Avila C., Geschwind S.A., Hanley J.M., Geoffrey F Joyce, Madison R., Pace J., Polich S.M, Wang M. Urologic diseases in America Project: analytical methods and principal findings. The Journal of Urology. 2005;173(3):933-7. [PubMed ID: 15711342]. https://doi.org/10.1097/01.ju.0000152365.43125.3b
Gupta M., Tomar R.S., Kaushik S., Mishra R.K., Sharma D. Effective antimicrobial activity of green ZnO nano particles of Catharanthus roseus. Frontiers in Microbiology. 2018;9:2030. doi: https://doi.org/10.3389/fmicb.2018.02030
Wang Z., Lee Y.H., Wu B., Horst A., Kang Y., Tang Y.J., Chen D.R. Anti-microbial activities of aerosolized transition metal oxide nanoparticles. Chemosphere. 2010;80(5):525-9. [PubMed ID: 20478610]. https://doi.org/10.1016/j.chemosphere.2010.04.047.
Waterstone M., Bewley S., Wolfe C. Incidence and predictors of severe obstetric morbidity: Case-control study. Obstetrical & Gynecological Survey. 2002;57(3):139-40.
Droepenu E.K., Amenyogbe E., Boatemaa M.A., Opoku E. Study of the antimicrobial activity of zinc oxide nanostructures mediated by two morphological structures of leaf extracts of Eucalyptus Robusta Sm. Heliyon. 2024; 10(14).
Rahimzadeh Torabi L. The Antibacterial Effects of Zno Nanoparticles on Patients with Urinary Tract Infection Isolated From Alzahra Hospital in Isfahan, Iran. Zahedan Journal of Research in Medical Sciences. 2017;19(11):e10359. https://doi.org/10.5812/zjrms.10359.
Rasheed Z.R., Abd A.N., H Hassan K. Antibacterial Activity of Zinc Oxide Nanoparticles Synthesized by Green Eichhornia Crassipes Extract Method. Frontiers in Biomedical Technologies. 2024; 11(4). https://doi.org/10.18502/fbt.v11i4.16503.
Chandra H., Patel D., Kumari P., Jangwan J.S., Yadav S. Phyto-mediated synthesis of zinc oxide nanoparticles of Berberis aristata: Characterization, antioxidant activity and antibacterial activity with special reference to urinary tract pathogens. Materials Science and Engineering C, Materials for Biological Applications. 2019;102:212-220. Doi: 10.1016/j.msec.2019.04.035.
Bohan A. Antibacterial activity of Zinc Oxide Nano particles against bacteria isolated from Infants with urinary Tract Infection. Al-Mustansiriyah Journal of Science. 2018; 29(2):34.
EI-Fallal A., A.El Fayoumy R., M.EI Zahed M. Antibacterial activity of biosynthesized zinc oxide nano particles using kombucha extract. Discover Applied Sciences. 2023; 5(3320).
آمار
تعداد مشاهده مقاله: 347
تعداد دریافت فایل اصل مقاله: 189
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب