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Opeyemi, Adeleke, Oni, Tolulope, Adunfe, Oluwatobi, Adeyemi, Babatunde, Akindehin, Oluwatosin, Adeeyo, Olusola. (1404). Effect of Osun River Heavy Metal Contamination on Testicular Function in Wistar Rats. سامانه مدیریت نشریات علمی, 80(5), 1259-1268. doi: 10.32598/ARI.80.5.3497
Adeleke Samson Opeyemi; Tolulope Ayodeji Oni; Oluwatobi Oluseun Adunfe; Babatunde Samuel Adeyemi; Oluwatosin Abosede Akindehin; Olusola Atilade Adeeyo. "Effect of Osun River Heavy Metal Contamination on Testicular Function in Wistar Rats". سامانه مدیریت نشریات علمی, 80, 5, 1404, 1259-1268. doi: 10.32598/ARI.80.5.3497
Opeyemi, Adeleke, Oni, Tolulope, Adunfe, Oluwatobi, Adeyemi, Babatunde, Akindehin, Oluwatosin, Adeeyo, Olusola. (1404). 'Effect of Osun River Heavy Metal Contamination on Testicular Function in Wistar Rats', سامانه مدیریت نشریات علمی, 80(5), pp. 1259-1268. doi: 10.32598/ARI.80.5.3497
Opeyemi, Adeleke, Oni, Tolulope, Adunfe, Oluwatobi, Adeyemi, Babatunde, Akindehin, Oluwatosin, Adeeyo, Olusola. Effect of Osun River Heavy Metal Contamination on Testicular Function in Wistar Rats. سامانه مدیریت نشریات علمی, 1404; 80(5): 1259-1268. doi: 10.32598/ARI.80.5.3497

Effect of Osun River Heavy Metal Contamination on Testicular Function in Wistar Rats

Archives of Razi Institute
مقاله 20، دوره 80، شماره 5، آذر و دی 2025، صفحه 1259-1268    اصل مقاله (1.43 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32598/ARI.80.5.3497
نویسندگان
Adeleke Samson Opeyemi1؛ Tolulope Ayodeji Oni* 1؛ Oluwatobi Oluseun Adunfe2؛ Babatunde Samuel Adeyemi3؛ Oluwatosin Abosede Akindehin4؛ Olusola Atilade Adeeyo5
1Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Nigeria.
2Department of Medical Laboratory Sciences, College of Basic Medical and Health Sciences, Fountain University, Osogbo, Nigeria.
3Department of Medical Laboratory Sciences, College of Health Sciences, McPherson University, Lagos, Nigeria.
4Faculty of Nursing Sciences, Trinity University, Lagos, Nigeria.
5Department of Anatomy, College of Health Sciences, Federal University of Oye-Ekiti, Oye, Nigeria.
چکیده
Introduction: The Osun River is prone to contamination from industrial, agricultural, and domestic activities, resulting in heavy metal pollution. Widespread contaminants such as lead, mercury, cadmium, and arsenic can build up in aquatic ecosystems, presenting serious health hazards to both wildlife and humans. Even at low concentrations, heavy metals are toxic, with the testes being particularly vulnerable given their essential functions in reproduction and hormone regulation. This study aims to examine the potential testicular damage resulting from prolonged exposure to heavy metal-contaminated Osun River water. 
Materials & Methods: Thirty adult male Wistar rats, averaging 160 g in weight, were randomly divided into six groups (A–F), with each group consisting of five rats. Group A functioned as the control, whereas groups B, C, and D were exposed to mercury (6.8 mg/kg), cyanide (25.8 mg/kg), and lead (47 mg/kg), respectively. Group E received a combination of two heavy metals (lead and mercury) and a toxic compound (cyanide), while group F was given unrestricted access to Osun River water. All substances were administered orally via an oral cannula for a duration of four weeks.  
Results: Statistical analysis revealed no significant differences among the groups exposed to mercury, cyanide, lead, and Osun River water. Toxic effects on the testes included disorganization of seminiferous tubules, altered spermatogenic cell arrangement, structural changes in the basal membrane, testicular stroma abnormalities, and reduced sperm count, motility, and viability. These effects were dose- and time-dependent, occurring even at low concentrations. 
Conclusion: The findings demonstrate that exposure to heavy metals, whether individually or through contaminated Osun River water, leads to significant testicular damage. The observed alterations in testicular architecture and sperm parameters emphasize the toxic impact of mercury, cyanide, and lead on reproductive health. This study underscores the importance of addressing environmental contamination to safeguard both human and animal reproductive systems.
کلیدواژه‌ها
Heavy metals؛ Osun river؛ Testicular damage؛ Toxic effects
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مراجع

References

  1. Afolabi-Balogun NB, Oni-Babalola OA, Adeleke II, Oseni FA, Bello RH, Bashir M, et al. Nutrients: Trace metals, micronutrients, oestrogen and B-vitamin content of Osun River: A river that runs southwestern Nigeria into the Atlantic Gulf of Guinea. bioRxiv. 2020. [DOI:10.1101/2020.08.20.259010]
  2. Anifowose AJ, Salawudeen C, Osundiya FO, Adelele AE, Awojide SH, Kolawole TO. Estimation of health risk to humans and source identification of heavy metals in a perennial river across the Osogbo Metropolis, Nigeria. Environ Sustain. 2023; 6(1):45-58. [DOI:10.1007/s42398-022-00256-3]
  3. Castilhos Z, Rodrigues-Filho S, Cesar R, Rodrigues AP, Villas-Bôas R, de Jesus I, et al. Human exposure and risk assessment associated with mercury contamination in artisanal gold mining areas in the Brazilian Amazon. Environ Sci Pollut Res Int. 2015; 22(15):11255-64. [DOI:10.1007/s11356-015-4340-y] [PMID]
  4. Zulaikhah ST, Wahyuwibowo J, Pratama AA. Mercury and its effect on human health: A review of the literature. Int J Public Health Sci. 2020; 9(2):103-14. [DOI:10.11591/ijphs.v9i2.20416]
  5. Dórea JG. Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean. Environ Res. 2021; 192:110199. [DOI:10.1016/j.envres.2020.110199] [PMID]
  6. Levallois P, Barn P, Valcke M, Gauvin D, Kosatsky T. Public health consequences of lead in drinking water. Curr Environ Health Rep. 2018; 5(2):255-62. [DOI:10.1007/s40572-018-0193-0] [PMID]
  7. Agency for Toxic Substances and Disease Registry (US). Toxicological Profile for Cyanide. Atlanta (GA): Agency for Toxic Substances and Disease Registry (US); 2006. [Link]
  8. Zuhra K, Szabo  The two faces of cyanide: An environmental toxin and a potential novel mammalian gasotransmitter. FEBS J. 2022; 289(9):2481-515. [DOI:10.1111/febs.16135] [PMID]
  9. Roychoudhury S, Saha MR, Saha MM. Environmental toxicants and male reproductive toxicity: Oxidation‑reduction potential as a new marker of oxidative stress in infertile men. In: Kesari K, editor. Networking of Mutagens in Environmental Toxicology. Cham: Springer; 2019. [DOI:10.1007/978-3-319-96511-6_5]
  10. Shivanoor SM, David M. Subchronic cyanide toxicity on male reproductive system of albino rat. Tox Res. 2015; 4(1):57–64. [DOI:10.1039/c4tx00064a]
  11. López‑BotellaA, Velasco I, Acién M, Sáez‑Espinosa P, Todolí‑Torró JL, Sánchez‑Romero R, et al. Impact of Heavy Metals on Human Male Fertility — An Overview. Antioxidants. 2021; 10(9):1473. [DOI:10.3390/antiox10091473]
  12. Moussa H, Hachfi L, Trimèche M, Najjar MF, Sakly R. Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury. Andrologia. 2011; 43(1):23-7. [PMID]
  13. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. Exp Suppl. 2012; 101:133-64. [DOI:10.1007/978-3-7643-8340-4_6] [PMID]
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