اخبار و اعلانات

 آمار

تعداد نشریات282
تعداد نشریات سازمان80
تعداد شماره‌ها3,188
تعداد مقالات35,336
تعداد مشاهده مقاله51,471,914
تعداد دریافت فایل اصل مقاله91,335,143
Qadr, Sayran, Hamad, Pishtiwan, Aziz, Sozan, Hamasalih, Rebwar, Ahmed, Mohsin. (1404). Assessment of the Antimicrobial Resistance Spectrum and Identification of Extended-spectrum ß-lactamase (ESBL) in Acinetobacter Baumannii From Clinical Samples in Erbil City. سامانه مدیریت نشریات علمی, 80(5), 1189-1198. doi: 10.22092/ari.2024.366860.3300
Sayran Sabr Qadr; Pishtiwan Ahmed Hamad; Sozan Hamashrif Aziz; Rebwar Muhammad Hamasalih; Mohsin Ali Ahmed. "Assessment of the Antimicrobial Resistance Spectrum and Identification of Extended-spectrum ß-lactamase (ESBL) in Acinetobacter Baumannii From Clinical Samples in Erbil City". سامانه مدیریت نشریات علمی, 80, 5, 1404, 1189-1198. doi: 10.22092/ari.2024.366860.3300
Qadr, Sayran, Hamad, Pishtiwan, Aziz, Sozan, Hamasalih, Rebwar, Ahmed, Mohsin. (1404). 'Assessment of the Antimicrobial Resistance Spectrum and Identification of Extended-spectrum ß-lactamase (ESBL) in Acinetobacter Baumannii From Clinical Samples in Erbil City', سامانه مدیریت نشریات علمی, 80(5), pp. 1189-1198. doi: 10.22092/ari.2024.366860.3300
Qadr, Sayran, Hamad, Pishtiwan, Aziz, Sozan, Hamasalih, Rebwar, Ahmed, Mohsin. Assessment of the Antimicrobial Resistance Spectrum and Identification of Extended-spectrum ß-lactamase (ESBL) in Acinetobacter Baumannii From Clinical Samples in Erbil City. سامانه مدیریت نشریات علمی, 1404; 80(5): 1189-1198. doi: 10.22092/ari.2024.366860.3300

Assessment of the Antimicrobial Resistance Spectrum and Identification of Extended-spectrum ß-lactamase (ESBL) in Acinetobacter Baumannii From Clinical Samples in Erbil City

Archives of Razi Institute
مقاله 13، دوره 80، شماره 5، آذر و دی 2025، صفحه 1189-1198    اصل مقاله (1.87 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2024.366860.3300
نویسندگان
Sayran Sabr Qadr* 1؛ Pishtiwan Ahmed Hamad2؛ Sozan Hamashrif Aziz3؛ Rebwar Muhammad Hamasalih2؛ Mohsin Ali Ahmed4
1Department of Medical Microbiology, College of Science, International University of Erbil, Erbil, Iraq.
2Department of Biology, College of Education, Salahaddin University-Erbil, Erbil, Iraq.
3Department of Medical Laboratory Technology, Shaqlawa Technical College, Erbil Polytechnic University, Erbil, Iraq.
4Department of Animal Resources, College of Agricultural Engineering Sciences, Salahaddin University-Erbil, Erbil, Iraq.
چکیده
Introduction: Acinetobacter baumannii is a dangerous opportunistic pathogen responsible for a wide range of various infections, particularly in healthcare settings, affecting immunocompromised individuals. It is a significant source of nosocomial infections due to its ability to produce extended-spectrum β-lactamases (ESBLs) and carbapenemase enzymes, making it a major concern for antibiotic resistance. 
Materials & Methods: To investigate the significant occurrence of ESBL-producing A. baumannii in hospitalized individuals, a total of 250 clinical specimens were obtained cultured on blood agar and MacConkey agar media. Identification of isolates was conducted using both conventional microbiological techniques and the automated VITEK 2 system. Duplicate isolates and specimens from colonization-prone sites, including throat and perianal areaswere excluded. Antimicrobial susceptibility and ESBL production were evaluated according to Clinical and Laboratory Standards Institute (CLSI) standards.
Results: Out of 250 clinical specimens, 60(24%) out of 250 were culture-positive for A. baumannii infection. Thirty out of sixty isolates (50%) showed an A. baumannii infection that produced ESBL. 86.67% of the isolated bacteria exhibited multidrug resistance overall (52/60). Resistance profiling revealed that amikacin had the greatest resistance rate among the 60 isolates (100%), while tigecycline showed the lowest resistance rate among just 10 isolates (16.67%). Notably, colistin demonstrated complete efficacy, with a 0.00% resistance rate, making it the most effective antibiotic against A. baumannii in this study. The presence of ESBL genes were correlated with antibiotic resistance, particularly with cephalosporin medicines.
Conclusion: In conclusion, the present study highlights the prevalence of ESBL-producing A. baumannii strains, emphasizing the need for cautious antibiotic use and systematic monitoring of resistance mechanisms. The emergence of new ESBL strains necessitates continuous surveillance and further research on other ESBL-associated genes.
کلیدواژه‌ها
Acinetobacter Baumannii؛ Antibiotic resistance؛ Extended-spectrum Β-lactamase genes
سایر فایل های مرتبط با مقاله
مراجع

 

 

 

References

  1. Lin MF, Lan CY. Antimicrobial resistance in Acinetobacter baumannii: From bench to bedside. World J Clin Cases. 2014; 2(12):787-814. [DOI:10.12998/wjcc.v2.i12.787] [PMID]
  2. Abdar MH, Taheri-Kalani M, Taheri K, Emadi B, Hasanzadeh A, Sedighi A, et al. Prevalence of extended-spectrum beta-lactamase genes in Acinetobacter baumannii strains isolated from nosocomial infections in Tehran, Iran. GMS Hyg Infect Control. 2019; 14:Doc02. [DOI:10.3205/dgkh000318]
  3. Abd El-Baky RM, Farhan SM, Ibrahim RA, Mahran KM, Hetta HF. Antimicrobial resistance pattern and molecular epidemiology of ESBL and MBL producing Acinetobacter baumannii isolated from hospitals in Minia, Egypt. Alex J Med. 2020; 56(1):4-13. [DOI:10.1080/20905068.2019.1707350]
  4. Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B. Clinical and pathophysiological overview of acinetobacter infections: A Century of Challenges. Clin Microbiol Rev. 2017; 30(1):409-47. [DOI:10.1128/cmr.00058-16] [PMID]
  5. Freire MP, de Oliveira Garcia D, Garcia CP, Campagnari Bueno MF, Camargo CH, Kono Magri ASG, et al. Bloodstream infection caused by extensively drug-resistant Acinetobacter baumannii in cancer patients: high mortality associated with delayed treatment rather than with the degree of neutropenia. Clin Microbiol Infect. 2016; 22(4):352-8. [DOI:10.1016/j.cmi.2015.12.010] [PMID]
  6. Morris FC, Dexter C, Kostoulias X, Uddin MI, Peleg AY. The Mechanisms of Disease Caused by Acinetobacter baumannii. Front Microbiol. 2019; 10:1601. [DOI:10.3389/fmicb.2019.01601] [PMID]
  7. Moosavian M, Ahmadi K, Shoja S, Mardaneh J, Shahi F, Afzali M. Antimicrobial resistance patterns and their encoding genes among clinical isolates of Acinetobacter baumannii in Ahvaz, Southwest Iran. MethodsX. 2020; 7:101031. [DOI:10.1016/j.mex.2020.101031] [PMID]
  8. Khoshnood S, Heidary M, Mirnejad R, Bahramian A, Sedighi M, Mirzaei H. Drug-resistant gram-negative uropathogens: A review. Biomed Pharmacother. 2017;94:982-94. [DOI:10.1016/j.biopha.2017.08.006] [PMID]
  9. Jiang W, Yang W, Zhao X, Wang N, Ren H. Klebsiella pneumoniae presents antimicrobial drug resistance for β-lactam through the ESBL/PBP signaling pathway. Exp Ther Med. 2020; 19(4):2449-56. [DOI:10.3892/etm.2020.8498]
  10. Dirar MH, Bilal NE, Ibrahim ME, Hamid ME. Prevalence of extended-spectrum β-lactamase (ESBL) and molecular detection of blaTEM, blaSHV and blaCTX-M genotypes among Enterobacteriaceae isolates from patients in Khartoum, Sudan. Pan Afr Med J. 2020; 37:213. [DOI:10.11604/pamj.2020.37.213.24988] [PMID]
  11. Ibrahim ME, Algak TB, Abbas M, Elamin BK. Emergence of bla (TEM), bla (CTX-M), bla (SHV) and bla (OXA) genes in multidrug-resistant Enterobacteriaceae and Acinetobacter baumannii in Saudi Arabia. Exp Ther Med. 2021; 22(6):1450. [DOI:10.3892%2Fetm.2021.10885] [PMID]
  12. Azizi M, Mortazavi SH, Etemadimajed M, Gheini S, Vaziri S, Alvandi A, et al. Prevalence of Extended-Spectrum β-Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran. Jundishapur J Microbiol. 2017; 10(12):e61522. [DOI:10.5812/jjm.61522]
  13. Hamasalih R, Abdulrahman Z. Antibiofilm potency of ginger (Zingiber officinale) and quercetin against Staphylococcus aureus isolated from urinary tract catheterized patients. Appl Ecol Environ Res. 2020; 18(1):219-36. [DOI:10.15666/aeer/1801_219236]
  14. Humphries R, Bobenchik AM, Hindler JA, Schuetz AN. Overview of changes to the clinical and laboratory standards institute performance standards for antimicrobial susceptibility testing, M100, 31st Edition. J Clin Microbiol. 2021; 59(12):e0021321. [DOI:10.1128/jcm.00213-21] [PMID]
  15. Bakr KI, Abdul-Rahman SM, Muhammad Hamasalih R. Molecular detection of β-lactamase genes in Klebsiella pneumoniae and Escherichia coli isolated from different clinical sources. Cell Mol Biol (Noisy-le-grand). 2022; 67(4):170-80. [DOI:10.14715/cmb/2021.67.4.19] [PMID]
  16. Feizabadi MM, Fathollahzadeh B, Taherikalani M, Rasoolinejad M, Sadeghifard N, Aligholi M, et al. Antimicrobial susceptibility patterns and distribution of blaOXA genes among Acinetobacter spp. Isolated from patients at Tehran hospitals. Jpn J Infect Dis. 2008; 61(4):274-8. [DOI:10.7883/yoken.JJID.2008.274] [PMID]
  17. Ting C, Jun A, Shun Z. Detection of the common resistance genes in Gram-negative bacteria using gene chip technology. Indian J Med Microbiol. 2013; 31(2):142-7. [DOI:4103/0255-0857.115230] [PMID]
  18. Shahcheraghi F, Abbasalipour M, Feizabadi M, Ebrahimipour G, Akbari N. Isolation and genetic characterization of metallo-β-lactamase and carbapenamase producing strains of Acinetobacter baumannii from patients at Tehran hospitals. Iran J Microbiol. 2011; 3(2):68-74. [PMID]
  19. Rezaee MA, Pajand O, Nahaei MR, Mahdian R, Aghazadeh M, Ghojazadeh M, et al. Prevalence of Ambler class A β-lactamases and ampC expression in cephalosporin-resistant isolates of Acinetobacter baumannii. Diagn Microbiol Infect Dis. 2013; 76(3):330-4. [DOI:10.1016/j.diagmicrobio.2013.04.003] [PMID]
  20. Jahangiri S, Malekzadegan Y, Motamedifar M, Hadi N. Virulence genes profile and biofilm formation ability of Acinetobacter baumannii strains isolated from inpatients of a tertiary care hospital in southwest of Iran. Gene Rep. 2019; 17:100481. [DOI:10.1016/j.genrep.2019.100481]
  21. Nowak P, Paluchowska PM, Budak A. Co-occurrence of carbapenem and aminoglycoside resistance genes among multidrug-resistant clinical isolates of Acinetobacter baumannii from Cracow, Poland. Med Sci Monit Basic Res. 2014; 20:9-14. [DOI:10.12659/msmbr.889811] [PMID]
  22. Choi WS, Kim SH, Jeon EG, Son MH, Yoon YK, Kim JY, et al. Nosocomial outbreak of carbapenem-resistant Acinetobacter baumannii in intensive care units and successful outbreak control program. J Korean Med Sci. 2010; 25(7):999-1004. [DOI:10.3346/jkms.2010.25.7.999] [PMID]
  23. Zeighami H, Valadkhani F, Shapouri R, Samadi E, Haghi F. Virulence characteristics of multidrug resistant biofilm forming Acinetobacter baumannii isolated from intensive care unit patients. BMC Infect Dis. 2019; 19(1):629. [DOI:10.1186/s12879-019-4272-0] [PMID]
  24. Howard A, O’Donoghue M, Feeney A, Sleator RD. Acinetobacter baumannii: An emerging opportunistic pathogen. Virulence. 2012; 3(3):243-50. [DOI:10.4161/viru.19700] [PMID]
  25. Poirel L, Bonnin RA, Nordmann P. Genetic basis of antibiotic resistance in pathogenic Acinetobacter species. IUBMB Life. 2011; 63(12):1061-7. [DOI:10.1002/iub.532] [PMID]
  26. Vahdani P, Yaghoubi T, Aminzadeh Z. Hospital acquired antibiotic-resistant acinetobacter baumannii infections in a 400-bed hospital in Tehran, Iran. Int J Prev Med. 2011; 2(3):127-30. [PMID]
  27. Saffari F, Monsen T, Karmostaji A, Azimabad FB, Widerström M. Significant spread of extensively drug-resistant Acinetobacter baumannii genotypes of clonal complex 92 among intensive care unit patients in a university hospital in southern Iran. J Med Microbiol. 2017; 66(11):1656-62. [DOI:10.1099/jmm.0.000619] [PMID]
  28. Zarifi H, Eslami G, Khaledi A, Vakili M, Vazini H. Prevalence of ESBLs in Acinetobacter baumannii isolated from intensive care unit (ICU) of Ghaem hospital, Mashhad, Iran. J Pure Appl Microbiol. 2017; 11(2):811-9. [DOI:10.22207/JPAM.11.2.20]
آمار
تعداد مشاهده مقاله: 492
تعداد دریافت فایل اصل مقاله: 551


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب