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Relative Frequency of HTLV-І Infection in Blood Donors in Ahvaz, Southwest of Iran | ||
| Archives of Razi Institute | ||
| مقاله 7، دوره 81، شماره 1، فروردین و اردیبهشت 2026، صفحه 53-58 اصل مقاله (576.3 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.32598/ARI.81.1.3182 | ||
| نویسندگان | ||
| Mehdi Parsanahad1؛ Roohangize Nashibi* 2؛ Manoochehr Makvandi1؛ Fateme Ahmadi2؛ Bijan Helli3؛ Zahra Lotfi4 | ||
| 1Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| 2Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| 3Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| 4Department of Infectious Diseases, School of Medicine, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| چکیده | ||
| Introduction: Human T-lymphotropic virus type I (HTLV-I) is recognized as the first human retrovirus. It constitutes a significant health concern in endemic areas, with HTLV-1 primarily disseminated through infected biological fluids, such as blood, breast milk, and semen. Contributory risk factors encompass unprotected sexual intercourse, intravenous drugs use, tissue transplantation, as well as blood and blood component donation. HTLV-I is implicated in two critical pathologies: Adult T-cell leukemia and tropical spastic paraparesis. The geographic prevalence of HTLV-I exhibits global variability, including within the context of Iran. This investigation was undertaken to assess the prevalence of the HTLV-I virus among blood donors in Ahvaz. Materials & Methods: In this cross-sectional analysis, a total of 777 blood donors were enrolled, comprising 771(99.2%) males and 6(0.8%) females, with a mean age of 38.08±8.42 years. All blood specimens were systematically evaluated for HTLV-I antibodies utilizing enzyme-linked immunosorbent assay (ELISA) in accordance with the manufacturer’s protocols. Results: Positive cases were identified through polymerase chain reaction (PCR) analysis utilizing peripheral blood mononuclear cells (PBMC) derived from the positive ELISA blood specimen. Among the 777 blood donors, a single case (0.1%) tested positive for the HTLV-І antibody. The individual in question was a 35-year-old male married with no documented history of blood transfusions, surgical procedures, dialysis, intravenous drug use, phlebotomy, or engagement in high-risk sexual behaviors, either personally or through his spouse. The PCR analysis yielded a negative result. Conclusion: The findings of this investigation indicate that HTLV-І infection is not endemic among blood donors in Ahvaz, and thus, the screening of blood samples for HTLV-І infection in this region does not seem to be warranted. | ||
| کلیدواژهها | ||
| Human T-lymphotropic virus type I (HTLV-І)؛ Blood donors؛ Ahvaz؛ Endemic | ||
| عنوان مقاله [English] | ||
| فراوانی نسبی عفونت HTLV-І در اهداکنندگان خون اهواز، جنوب غرب ایران | ||
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