اخبار و اعلانات

 آمار

تعداد نشریات287
تعداد نشریات سازمان85
تعداد شماره‌ها3,159
تعداد مقالات35,108
تعداد مشاهده مقاله50,533,831
تعداد دریافت فایل اصل مقاله90,481,911
Kalantar Neyestanki, Mohammad Hassan, Jalali Mashayekhi, Farideh, Samimi, Fatemeh, Soleimani, Homa. (1404). Investigation of the Effect of Extremely Low-frequency Electromagnetic Fields Exposure and Curcumin During the Embryonic Period on Catalase and Superoxide Dismutase Activities of Plasma and Liver Tissue of Juvenile Wistar Rats. سامانه مدیریت نشریات علمی, 14(6), 654-660. doi: 10.22034/jmpb.2025.367258.1783
Mohammad Hassan Kalantar Neyestanki; Farideh Jalali Mashayekhi; Fatemeh Samimi; Homa Soleimani. "Investigation of the Effect of Extremely Low-frequency Electromagnetic Fields Exposure and Curcumin During the Embryonic Period on Catalase and Superoxide Dismutase Activities of Plasma and Liver Tissue of Juvenile Wistar Rats". سامانه مدیریت نشریات علمی, 14, 6, 1404, 654-660. doi: 10.22034/jmpb.2025.367258.1783
Kalantar Neyestanki, Mohammad Hassan, Jalali Mashayekhi, Farideh, Samimi, Fatemeh, Soleimani, Homa. (1404). 'Investigation of the Effect of Extremely Low-frequency Electromagnetic Fields Exposure and Curcumin During the Embryonic Period on Catalase and Superoxide Dismutase Activities of Plasma and Liver Tissue of Juvenile Wistar Rats', سامانه مدیریت نشریات علمی, 14(6), pp. 654-660. doi: 10.22034/jmpb.2025.367258.1783
Kalantar Neyestanki, Mohammad Hassan, Jalali Mashayekhi, Farideh, Samimi, Fatemeh, Soleimani, Homa. Investigation of the Effect of Extremely Low-frequency Electromagnetic Fields Exposure and Curcumin During the Embryonic Period on Catalase and Superoxide Dismutase Activities of Plasma and Liver Tissue of Juvenile Wistar Rats. سامانه مدیریت نشریات علمی, 1404; 14(6): 654-660. doi: 10.22034/jmpb.2025.367258.1783

Investigation of the Effect of Extremely Low-frequency Electromagnetic Fields Exposure and Curcumin During the Embryonic Period on Catalase and Superoxide Dismutase Activities of Plasma and Liver Tissue of Juvenile Wistar Rats

Journal of Medicinal plants and By-products
مقاله 19، دوره 14، شماره 6، بهمن و اسفند 2025، صفحه 654-660    اصل مقاله (1.13 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.367258.1783
نویسندگان
Mohammad Hassan Kalantar Neyestanki1؛ Farideh Jalali Mashayekhi2؛ Fatemeh Samimi2؛ Homa Soleimani* 1، 3
1Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
2Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences, Arak, I.R. Iran
3Department of Medical physics, School of Paramedical Sciences, Arak University of Medical Sciences, Arak, Iran
چکیده
To investigate the effectiveness of extremely low-frequency electromagnetic field (ELF-EMF) and curcumin on the enzyme level of Catalase (CAT) and Superoxide Dismutase (SOD) in the plasma and liver of neonates that had been irradiated during pregnancy. Five males and twenty female rats were mated, and vaginal plaques were observed. The pregnant rats were then divided into six groups. During pregnancy, the EMF group was exposed to ELF-EMF for 30 min/day, the curcumin group received a single intraperitoneal dose of 50 mg/kg curcumin, and the EMF + Curcumin group was exposed to ELF-EMF and injected intraperitoneally with curcumin. The DMSO group was injected intraperitoneally with DMSO (curcumin solvent), and the sham group was placed in the solenoid under the same conditions as the EMF group but without ELF-EMF exposure. The sixth group was the control group. After birth, the offspring were breastfed by their mothers until the end of the lactation period (28 days). Once the offspring reached 4 weeks of age, they were sacrificed, separated by sex, and divided into six experimental groups according to their mothers' groups assignments. CAT and SOD levels in the plasma and liver were assayed. Data analysis showed curcumin and stress changed serum SOD (P = 0.021) and CAT tissue (P = 0.033) levels based on gender.  Additionally, ELF-EMF exposure reduced serum catalase activity (P = 0.002). This change was sex-dependent, and in the presence of curcumin, the mean values returned to the normal level. ELF-EMF (1.5mT) exposure during pregnancy had a potentially sex-dependent effect on serum CAT activity in juveniles.
کلیدواژه‌ها
Radiation exposure؛ Diferuloylmethane, Superoxide dismutase, Catalase, Embryonic period
مراجع
  1. Kıvrak E.G., Yurt K.K., Kaplan A.A., Alkan I., Altun G. Effects of electromagnetic field exposure on the antioxidant defense system. Journal Microscope Ultrastructure. 2017; 5(4):167-76.
  2. Mohammadi B., Sadegh M., Soleimani H. Prenatal chronic exposure to electromagnetic fields modulated adenosine deaminase activity in serum and brain of Wistar rats' offspring. Journal of Microwave Power and Electromagnetic Energy. 2021; 55(4):303-15.
  3. Schuermann D., Mevissen M. Manmade electromagnetic fields and oxidative stress: biological effects and health consequences. International Journal of Molecular Sciences. 2021; 22(7):3772.
  4. Tofani S., Barone D., Berardelli M., Berno E., Cintorino M., Foglia L., Ossola P., Ronchetto F., Toso E., Eandi M. Static and ELF magnetic fields enhance the in vivo anti-tumor efficacy of cis-platin against Lewis lung carcinoma, but not of cyclophosphamide against B16 melanotic melanoma. Pharmacological Research. 2003; 48(1):83-90.
  5. Yuge L., Okubo A., Miyashita T., Kumagai T., Nikawa T., Takeda S.I., Kanno M., Urabe Y., Sugiyama M., Kataoka K. Physical stress by magnetic force accelerates differentiation of human osteoblasts. Biochemical and Biophysical Research Communications. 2003; 311(1):32-8.
  6. Pirozzoli M.C., Marino C., Lovisolo G.A., Laconi C., Mosiello L., Negroni A. Effects of 50 Hz electromagnetic field exposure on apoptosis and differentiation in a neuroblastoma cell line. Bioelectromagnetics. 2003; 24(7):510-6.
  7. Panagopoulos D.J., Karabarbounis A., Yakymenko I., Chrousos G.P. Human-made electromagnetic fields: ion forced-oscillation and voltage-gated ion channel dysfunction, oxidative stress, and DNA damage. International Journal of Oncology. 2021; 59(1):1-16.
  8. Bertagna F., Lewis R., Silva S.R.P., McFadden J., Jeevaratnam K. Effects of electromagnetic fields on neuronal ion channels: a systematic review. Annals of the New York Academy of Sciences. 2021; 1499(1):82-103.
  9. Xu Y., Jia Y., Ge M., Lu L., Yang L., Zhan X. Effects of ion channel blockers on electrical activity of stochastic Hodgkin–Huxley neural networks under electromagnetic induction. Neurocomputing. 2018; 283:196-204.
  10. Aldinucci C., Palmi M., Sgaragli G., Benocci A., Meini A., Pessina F., Pessina G.P. The effect of pulsed electromagnetic fields on the physiological behavior of a human astrocytoma cell line. Biochimica et Biophysica Acta- Molecular Cell Research. 2000; 1499(1):101-8.11.
  11. Takahashi M.A., Asada K. Superoxide anion permeability of phospholipid membranes and chloroplast thylakoids. Archives of Biochemistry and Biophysics. 1983; 226(2):558-66.
  12. Blank M. Protein and DNA reactions stimulated by electromagnetic fields. Electromagnetic Biology and Medicine. 2008; 27(1):3-23.
  13. Dhama K., Karthik K., Khandia R., Munjal A., Tiwari R., Rana R., Khurana S.K., Ullah S., Ullah Khan R., Alagawany M., Farag M.R., Dadar M., Joshi S.K. Medicinal and therapeutic potential of herbs and plant metabolites/extracts countering viral pathogens: current knowledge and future prospects. Current Drug Metabolism. 2018; 19(3):236-63.
  14. Jenča A., Mills D.K., Ghasemi H., Saberian E., Jenča A., Karimi Forood A.M., Petrášová A., Jenčová J., Jabbari Velisdeh Z., Zare-Zardini H., Ebrahimifar M. Herbal therapies for cancer treatment: a review of phytotherapeutic efficacy. Biologics: Targets and Therapy. 2024; 18:229-55.
  15. Kocaadam B., Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition. 2017; 57(14):2889-95.
  16. Almatroodi S.A., Alrumaihi F., Alsahli M.A., Alhommrani M.F., Khan A., Rahmani A.H. Curcumin, an active constituent of turmeric spice: implication in the prevention of lung injury induced by benzo (a) pyrene (BaP) in rats. Molecules (Basel, Switzerland). 2020; 25(5):1049.
  17. Zheng B., McClements D.J. Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability. Molecules (Basel, Switzerland). 2020; 25(12):2791.
  18. Shahrajabian M.H., Sun W. The golden spice for life: turmeric with the pharmacological benefits of curcuminoids components, including curcumin, bisdemethoxycurcumin, and demethoxycurcumins. Current Organic Synthesis. 2024; 21(5):665-83.
  19. Farzaei M.H., Zobeiri M., Parvizi F., El-Senduny F.F., Marmouzi I., Coy-Barrera E., Naseri R., Nabavi S.M., Rahimi R., Abdollahi M. Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients. 2018; 10(4):448.
  20. Ak T., Gülçin I. Antioxidant and radical scavenging properties of curcumin. Chemico-Biological Interactions. 2008; 174(1):27-37.
  21. Bertoncini-Silva C., Vlad A., Ricciarelli R., Fassini P.G., Suen V.M.M., Zingg J-M. Enhancing the bioavailability and bioactivity of curcumin for disease prevention and treatment. Antioxidants (Basel, Switzerland). 2024; 13(3):331.
  22. Zheng B., McClements D.J. Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability. Molecules (Basel, Switzerland). 2020; 25(12):2791.
  23. Pouliquen D.L., Trošelj K.G., Anto R.J. Curcuminoids as anticancer drugs: pleiotropic effects, potential for metabolic reprogramming and prospects for the future. Pharmaceutics. 2023; 15(5):1612.
  24. Sharma S., Shukla S. Effect of electromagnetic radiation on redox status, acetylcholine esterase activity and cellular damage contributing to the diminution of the brain working memory in rats. Journal of Chemical Neuroanatomy. 2020; 106:101784.
  25. Ghanbari A.A., Shabani K., Mohammad Nejad D. Protective effects of vitamin E consumption against 3MT electromagnetic field effects on oxidative parameters in substantia nigra in rats. Basic and Clinical Neuroscience. 2016; 7(4):315-22.
  26. Al-Ani L.A., Dandoti S.S., Khalil I., Khan A., Nair R.S., Mohan S. Curcumin as a functional food in cancer. In: Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases. CRC Press; 2023. p. 167-96.
  27. Rageh M.M., El-Gebaly R.H., El-Bialy N.S. Assessment of genotoxic and cytotoxic hazards in brain and bone marrow cells of newborn rats exposed to extremely low-frequency magnetic field. Journal of Biomedicine and Biotechnology. 2012; 2012:716023.
  28. Asl J.F., Goudarzi M., Mansouri E., Shoghi H. Rosmarinic acid protects the testes of rats against cell phone and ultra-high frequency waves induced toxicity. Iranian Journal of Medical Sciences. 2024; 49(3):237.
  29. Eskandani R., Zibaii M.I. Unveiling the biological effects of radio-frequency and extremely-low frequency electromagnetic fields on the central nervous system performance. BioImpacts. 2024; 14(1):1-10.
  30. Sharma S., Bahel S., Katnoria J.K. Evaluation of oxidative stress and genotoxicity of 900 MHz electromagnetic radiations using Trigonella foenum-graecum test system. Protoplasma. 2023; 260(1):209-24.
  31. Kalantar M.H., Bayat P-D., Ghaffari Khaligh S., Soleimani H. The role of curcumin during pregnancy on the exposed fetuses' tissues of Wistar rats to electromagnetic field. Medicine. 2024; 43(1):71-80.
  32. Woolson R.F., Bean J.A., Rojas P.B.J. Sample size for case-control studies using Cochran's statistic. Biometrics. 1986; 42(4):927-32.
  33. Kander M.C., Cui Y., Liu Z. Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases. Journal of Cellular and Molecular Medicine. 2017; 21(5):1024-32.
  34. Lee B-C., Johng H-M., Lim J-K., Jeong J-H., Baik K-Y., Nam T-J., Lee J.H., Kim J., Sohn U.D., Yoon G., Shin S., Soh K-S. Effects of extremely low-frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study. Journal of Photochemistry and Photobiology B: Biology. 2004; 73(1):43-8.
  35. Singh S., Kapoor N. Health implications of electromagnetic fields: mechanisms of action, and research needs. Advances in Biology. 2014; 2014:198609.
  36. Martínez-Sámano J.F., Torres-Durán P.V., Juárez-Oropeza M.A., Elías-Viñas D., Verdugo-Díaz L. Effects of acute electromagnetic field exposure and movement restraint on antioxidant system in liver, heart, kidney and plasma of Wistar rats: a preliminary report. International Journal of Radiation Biology. 2010; 86(12):1088-94.
  37. Kilic A., Ustunova S., Bulut H., Meral I. Pre- and postnatal exposure to 900 MHz electromagnetic fields induce inflammation and oxidative stress, and alter renin-angiotensin system components differently in male and female offspring. Life Sciences. 2023; 321:121627.
  38. Giergiel M., Lopucki M., Stachowicz N., Kankofer M. The influence of age and gender on antioxidant enzyme activities in humans and laboratory animals. Anticancer Research. 2012; 24(1):561-9.
  39. Bolzán A.D., Bianchi M.S., Bianchi N.O. Superoxide dismutase, catalase and glutathione peroxidase activities in human blood: influence of sex, age and cigarette smoking. Clinical Biochemistry. 1997; 30(6):449-54.
  40. Reale M., Kamal M.A., Patruno A., Costantini E., D'Angelo C., Pesce M., Greig N.H. Neuronal cellular responses to extremely low-frequency electromagnetic field exposure: implications regarding oxidative stress and neurodegeneration. PLoS One. 2014; 9(5): e104973.
  41. Srinivasan M., Rajendra Prasad V., Menon V.P. Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutation Research. 2006; 611(1-2):96-103.
  42. Li W., Jiang L., Lu X., Liu X., Ling M. Curcumin protects radiation-induced liver damage in rats through the NF-κB signaling pathway. BMC Complementary Medicine and Therapies. 2021; 21(1):10.
  43. Luo X., Chen M., Duan Y., Duan W., Zhang H., He Y., Yin C., Sun G., Sun X. Chemoprotective action of lotus seedpod procyanidins on oxidative stress in mice induced by extremely low-frequency electromagnetic field exposure. Biomedicine & Pharmacotherapy. 2016; 82:640-8.
  44. Barati M., Darvishi B., Javidi M.A., Mohammadian A., Shariatpanahi S.P., Eisavand M.R., Majid Ansari A. Cellular stress response to extremely low-frequency electromagnetic fields (ELF-EMF): an explanation for controversial effects of ELF-EMF on apoptosis. Cell Proliferation. 2021; 54(7): e13154.
  45. Hewlings S.J., Kalman D.S. Curcumin: a review of its effects on human health. Foods. 2017; 6(4):92.
  46. Mattson M.P. Metal-catalyzed disruption of membrane protein and lipid signaling in the pathogenesis of neurodegenerative disorders. Annals of the New York Academy of Sciences. 2004; 1012(1):37-50.
  47. Engwa G.A., Okolie R.A., Chidili J.P.C., Okore P.A., Onu P.C., Ugwu M.O., Oko D.E., Ferdinand P.U. Relationship of oxidative stress and antioxidant response with vaso-occlusive crisis in sickle cell anaemia. African Health Sciences. 2021; 21(1):150-8.
  48. Oktem F., Ozguner F., Mollaoglu H., Koyu A., Uz E. Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin. Archives of Medical Research. 2005; 36(3):350-5.
آمار
تعداد مشاهده مقاله: 359
تعداد دریافت فایل اصل مقاله: 341


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب