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Hosseini, Seyedeh Delafruz, Yasaghi, Mohammad, Saffar, Homina, Nassaj Torshizi, Fatemeh, Vaez, Ali, Mobasheri, Elham, Tabarraei, Alijan. (1404). Silent Threat: Investigating the Prevalence of Cytomegalovirus in Expectant Mothers in Northern Iran, Gorgan. سامانه مدیریت نشریات علمی, 80(3), 725-732. doi: 10.66224/ARI.2025.80.3.725
Seyedeh Delafruz Hosseini; Mohammad Yasaghi; Homina Saffar; Fatemeh Nassaj Torshizi; Ali Vaez; Elham Mobasheri; Alijan Tabarraei. "Silent Threat: Investigating the Prevalence of Cytomegalovirus in Expectant Mothers in Northern Iran, Gorgan". سامانه مدیریت نشریات علمی, 80, 3, 1404, 725-732. doi: 10.66224/ARI.2025.80.3.725
Hosseini, Seyedeh Delafruz, Yasaghi, Mohammad, Saffar, Homina, Nassaj Torshizi, Fatemeh, Vaez, Ali, Mobasheri, Elham, Tabarraei, Alijan. (1404). 'Silent Threat: Investigating the Prevalence of Cytomegalovirus in Expectant Mothers in Northern Iran, Gorgan', سامانه مدیریت نشریات علمی, 80(3), pp. 725-732. doi: 10.66224/ARI.2025.80.3.725
Hosseini, Seyedeh Delafruz, Yasaghi, Mohammad, Saffar, Homina, Nassaj Torshizi, Fatemeh, Vaez, Ali, Mobasheri, Elham, Tabarraei, Alijan. Silent Threat: Investigating the Prevalence of Cytomegalovirus in Expectant Mothers in Northern Iran, Gorgan. سامانه مدیریت نشریات علمی, 1404; 80(3): 725-732. doi: 10.66224/ARI.2025.80.3.725

Silent Threat: Investigating the Prevalence of Cytomegalovirus in Expectant Mothers in Northern Iran, Gorgan

Archives of Razi Institute
مقاله 22، دوره 80، شماره 3، مرداد و شهریور 2025، صفحه 725-732    اصل مقاله (545.01 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.66224/ARI.2025.80.3.725
نویسندگان
Seyedeh Delafruz Hosseini1؛ Mohammad Yasaghi1؛ Homina Saffar2؛ Fatemeh Nassaj Torshizi3؛ Ali Vaez4؛ Elham Mobasheri5؛ Alijan Tabarraei* 6
1Infectious Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
2Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
3Student research committee, Golestan University of Medical Sciences, Gorgan, Iran.
4Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
5Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
6Golestan University of medical Sciences
چکیده
Cytomegalovirus (CMV) infection during pregnancy is the leading cause of congenital infections globally, often resulting in significant health issues in newborns. These issues include sensorineural hearing loss, which can affect communication and language development, and neurodevelopmental delays that manifest as cognitive impairments, motor dysfunction, and behavioral challenges. The virus can be transmitted from the mother to the fetus, particularly if the mother experiences a primary infection during pregnancy. Early detection through maternal screening and fetal diagnostic tests, such as polymerase chain reaction (PCR) analysis of amniotic fluid, is crucial. Prompt management strategies, including antiviral therapies and immunoglobulin treatments, are essential to reduce viral load and mitigate these risks, thereby improving outcomes for affected infants. Vaginal secretions and blood specimens of 315 pregnant women referred to an educational hospital in the North east of Iran were tested for HCMV using PCR and ELISA assays. Chi-Square test was utilized to evaluate the association of qualitative variables and the level of significance was set at p≤0.05. Moreover, statistical analysis was performed using SPSS Statistics V.26.0. The findings of the molecular and serological investigation of cytomegalovirus (CMV) in the current population revealed that 16.2% (51/315) of the individuals tested positive for DNA-CMV, 87.6% (276/315) displayed IgG antibodies, and 3.2% (10/315) had IgM antibodies. Studying the prevalence of CMV in pregnant women is crucial to understand the extent of maternal and fetal exposure to this virus, which can lead to significant congenital disabilities and developmental issues in newborns. This data is essential for developing effective screening protocols and preventive measures to mitigate the health risks associated with CMV infections during pregnancy.
کلیدواژه‌ها
Human Cytomegalovirus؛ HHV-5؛ Pregnant women؛ Iran
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مراجع
  1. Nicloux M, Peterman L, Parodi M, Magny J-F. Outcome and management of newborns with congenital cytomegalovirus infection. Archives de Pédiatrie. 2020;27(3):160-5.
  2. Gorun F, Motoi S, Malita D, Navolan DB, Nemescu D, Olariu TR, et al. Cytomegalovirus seroprevalence in pregnant women in the western region of Romania: A large-scale study. Experimental and Therapeutic Medicine. 2020;20(3):2439-43.
  3. Porobic-Jahic H, Skokic F, Ahmetagic S, Piljic D, Jahic R, Petrovic J. Cytomegalovirus infection in pregnancy-our experiences. Medical Archives. 2019;73(3):149.
  4. Leruez-Ville M, Foulon I, Pass R, Ville Y. Cytomegalovirus infection during pregnancy: state of the science. American journal of obstetrics and gynecology. 2020;223(3):330-49.
  5. Lakzayi E, Fozouni L, Pordeli H. A seromolecular study on the prevalence of cytomegalovirus in pregnant women living in Golestan province, Iran. Shiraz E-Medical Journal. 2020;21(7).
  6. Park HW, Cho MH, Bae SH, Lee R, Kim KS. Incidence of postnatal CMV infection among breastfed preterm infants: a systematic review and meta-analysis. Journal of Korean medical science. 2021;36(12).
  7. Sharghi M, Musavi H, Mansurkhani SM, Kooti W, Behzadifar M, Ashrafi-Zadeh H, et al. Seroprevalence of cytomegalovirus among women of reproductive age in iran: A systematic review and meta-analysis. Iranian journal of public health. 2019;48(2):206.
  8. Beaudoin ML, Renaud C, Boucher M, Kakkar F, Gantt S, Boucoiran I. Perspectives of women on screening and prevention of CMV in pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2021;258:409-13.
  9. Hosseini SD, Yasaghi M, Mobasheri E, Nikoo HR, Tabarraei A. Molecular and Serological Epidemiology of Herpes Simplex Virus Type 1 and 2 in Pregnant Women of Gorgan City, North East of Iran. Journal of reproduction & infertility. 2023;24(1):35.
  10. Yasaghi M, Hosseini SD, Moradi A, Hassanpour M, Tabarraei A. Molecular detection of HHV-1, HHV-2, HHV-5 and HBV in semen of fertile and infertile men by multiplex PCR method. Iranian Journal of Microbiology. 2022;14(6):921.
  11. Mohebbi A, Mamizadeh Z, Bagheri H, Sharifnezhad F, Tabarraei A, Yazdi M. Prevalent latent human cytomegalovirus genotype b2 in biopsy samples of gastric cancer. Future Virology. 2020;15(2):71-8.
  12. Sartori P, Baud D, de Tejada BM, Farin A, Rossier M-C, Rieder W, et al. Cytomegalovirus infection during pregnancy: cross-sectional survey of knowledge and prevention practices of healthcare professionals in French-speaking Switzerland. Virology journal. 2024;21(1):45.
  13. Chatzakis C, Ville Y, Makrydimas G, Dinas K, Zavlanos A, Sotiriadis A. Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences. American journal of obstetrics and gynecology. 2020;223(6):870-83. e11.
  14. Hosseinzadeh Adli A, Karami C, Baghban Rahimi S, Mirarab A, Tabarraei A. What family doctors know about congenital CMV: a regional survey in Iran. Italian Journal of Pediatrics. 2018;44(1):31.
  15. Tazarghi SA, Tabarraei A, Naeimi M, Moradi A, Ahmadi A, Javid N. Detection of CMV and EBV DNA in PBMCs of MS Patients and Healthy Individuals in Gorgan, Iran. مجله ویروس شناسی ایران. 2017;11(3):27-32.
  16. Saravi NM, Aghajani F, Najafi A, Khajavi R, Rahmani Z, Jalali H, et al. A seromolecular study to determine the prevalence of cytomegalovirus in pregnant women referred to health centers in the north of Iran. Iranian journal of microbiology. 2023;15(4):594.
  17. Yeshwondm M, Balkachew N, Delayehu B, Mekonen G. Seroepidemiology study of cytomegalovirus and rubella among pregnant women at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Ethiopian Journal of Health Sciences. 2016;26(5):427-38.
  18. Ghasemi FS, Rasti S, Piroozmand A, Fakhrie-Kashan Z, Mousavi SGA. Comparison of the Frequency of anti-CMV,-Rubella and-HSV antibodies in women with spontaneous abortion and normal delivery. Feyz Medical Sciences Journal. 2015;19(1):86-92.
  19. Fulkerson HL, Nogalski MT, Collins-McMillen D, Yurochko AD. Overview of human cytomegalovirus pathogenesis. Human Cytomegaloviruses: Methods and Protocols. 2021:1-18.
  20. Plotogea M, Isam AJ, Frincu F, Zgura A, Bacinschi X, Sandru F, et al. An overview of cytomegalovirus infection in pregnancy. Diagnostics. 2022;12(10):2429.
  21. Choodinatha HK, Jeon MR, Choi BY, Lee K-N, Kim HJ, Park JY. Cytomegalovirus infection during pregnancy. Obstetrics & Gynecology Science. 2023;66(6):463-76.
  22. Dana Flanders W, Lally C, Dilley A, Diaz‐Decaro J. Estimated cytomegalovirus seroprevalence in the general population of the United States and Canada. Journal of Medical Virology. 2024;96(3):e29525.
  23. Lourtet-Hascoet J, Mine L, Spindler L, Pilmis B, Aubert M, El Mituialy A, et al. Epidemiology of symptomatic infective anoproctitis in a population of men having sex with men (MSM). Infection. 2022;50(4):933-40.
  24. Adler SP. Screening for cytomegalovirus during pregnancy. Infectious diseases in obstetrics and gynecology. 2011;2011(1):942937.
  25. Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK. The “silent” global burden of congenital cytomegalovirus. Clinical microbiology reviews. 2013;26(1):86-102.
  26. Balegamire SJ, Renaud C, Mâsse B, Zinszer K, Gantt S, Giguere Y, et al. Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec. PloS one. 2021;16(6):e0252309.
  27. Pesch MH, Saunders NA, Abdelnabi S. Cytomegalovirus infection in pregnancy: prevention, presentation, management and neonatal outcomes. Journal of midwifery & women's health. 2021;66(3):397-402.
  28. Ali SF, Al-Ahmer SD. Molecular detection of cytomegalovirus (CMV) and presence of bacterial infection in aborted women. 2020.
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