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Comparative genotoxic and histopathological effects of copper nanoparticles and copper chloride in goldfish (Carassius auratus) | ||
| Iranian Journal of Fisheries Sciences | ||
| دوره 23، شماره 3، مرداد 2024، صفحه 485-503 اصل مقاله (539.39 K) | ||
| شناسه دیجیتال (DOI): 10.22092/ijfs.2024.131228 | ||
| نویسندگان | ||
| C. Yavaş* 1؛ N. Gülsoy2 | ||
| 1Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, Istanbul, Turkiye | ||
| 2Department of Biology, Faculty of Sciences, Marmara University, Istanbul, Turkiye | ||
| چکیده | ||
| The purpose of the current study was to ascertain the comparative effects of compounds, copper (II) oxide nanoparticles (nCuO) and copper salt (CuCl2), on the genotoxicity and histopathology of goldfish (Carassius auratus) for acute exposures of 24, 48, 72, and 96 h (concentrations: 100, 150, 200, and 1, 1.5, 2 mg/L nCuO and CuCl2, respectively). The peripheral erythrocytes were obtained for that purpose from the caudal vein in each individual. The Comet assay and micronucleus test were used to evaluate genotoxicity, and gill tissues were prepared for histopathology. High levels of nCuO and CuCl2 concentrations and acute exposure (96-hour) increased the percentage of DNA in the comet tails, olive tail moments, and micronucleus counts showed genotoxic effects on exposed fish. Also, the gill tissue alterations were observed and changed as the lifting of the respiratory epithelium, hyperplasia of the lamellar epithelium, incomplete, and complete fusion of several lamellae, and hypertrophy. Genotoxicity for nCuO and CuCl2 was discovered to be a concentration and time-dependent phenomenon. In general, experimental groups showed significant impacts (p=0.05) on concentrations and exposure periods, which may contribute to understanding the mechanism of nCuO and CuCl2-induced genotoxicity in the fish. | ||
| کلیدواژهها | ||
| Copper؛ Micronucleus؛ Gill histopathology؛ Genotoxicity؛ Comet assay؛ Toxicity | ||
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