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The role of Rosa damascena Mill. on acute hypoxia | ||
| Natural Compounds Chemistry | ||
| دوره 2، شماره 1، دی 2023، صفحه 60-67 اصل مقاله (538.82 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22092/jncc.2023.129601 | ||
| نویسندگان | ||
| Mohammad Hossein Hosseinzadeh* 1؛ Parham Mortazavi2؛ Zahra Hashemi3؛ Amirhosein Arab4؛ Mohammad Eghbali3؛ Mohammad Ali Ebrahimzadeh3 | ||
| 1Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 2Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 3Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 4Student Research Committee and Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran | ||
| چکیده | ||
| Background: In the Rosaceae family, Rosa damascene Mill. is an important medicinal plant. Studies reported its antioxidant, cardioprotective, and neuroprotective effects that may be related to the anti-hypoxic activity. So, we investigated the anti-hypoxic effects of R. damascenaare in this study to evaluate the possible mechanism of plant effectiveness in cardiovascular and neurological disease. Methods: The R. damascenaare flowers were extracted with methanol by maceration method and anti-hypoxic activities were evaluated in haemic, asphyctic, and circulatory models. Results: In asphyctic hypoxia, extract at 250 mg/kg increased the survival time to 21.53±1.21 minutes, which was significantly lower (P<0.0001) than phenytoin (29.60±1.34 minutes). In haemic hypoxia, extract effects were similar to propranolol (P>0.05) at 125, and 250 mg/kg (15.85±0.69 and 16.19±1.71 vs. 16.44±1.39 minutes, P>0.05). In circulatory hypoxia, extract significantly increased the survival time at 250 mg/kg compared to the negative control (13.64±1.51 vs. 9.79±0.56 minutes, P<0.01) but its effect was weaker than propranolol (16.44±1.39 minutes). Conclusion: R. damascenaare show potent anti-hypoxic activity in the haemic model. Its effects were significant in higher doses in asphyctic and circulatory models. | ||
| کلیدواژهها | ||
| Cardiovascular Diseases؛ Reactive Oxygen Species؛ Asphyxia؛ Ischemia؛ Stroke | ||
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