اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,849
تعداد مقالات32,328
تعداد مشاهده مقاله41,449,339
تعداد دریافت فایل اصل مقاله18,649,620
Sabah, T, AL-Ghaban, N. M. H. (1402). Evaluation of the Effects of Amoxicillin on Tooth Development in Rats by Histological and Histomorphometric Study. سامانه مدیریت نشریات علمی, 78(4), 1333-1341. doi: 10.32592/ARI.2023.78.4.1333
T Sabah; N. M. H AL-Ghaban. "Evaluation of the Effects of Amoxicillin on Tooth Development in Rats by Histological and Histomorphometric Study". سامانه مدیریت نشریات علمی, 78, 4, 1402, 1333-1341. doi: 10.32592/ARI.2023.78.4.1333
Sabah, T, AL-Ghaban, N. M. H. (1402). 'Evaluation of the Effects of Amoxicillin on Tooth Development in Rats by Histological and Histomorphometric Study', سامانه مدیریت نشریات علمی, 78(4), pp. 1333-1341. doi: 10.32592/ARI.2023.78.4.1333
Sabah, T, AL-Ghaban, N. M. H. Evaluation of the Effects of Amoxicillin on Tooth Development in Rats by Histological and Histomorphometric Study. سامانه مدیریت نشریات علمی, 1402; 78(4): 1333-1341. doi: 10.32592/ARI.2023.78.4.1333

Evaluation of the Effects of Amoxicillin on Tooth Development in Rats by Histological and Histomorphometric Study

Archives of Razi Institute
مقاله 20، دوره 78، شماره 4، مهر و آبان 2023، صفحه 1333-1341    اصل مقاله (564.84 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.4.1333
نویسندگان
T Sabah* ؛ N. M. H AL-Ghaban
Oral Diagnosis Department, College of Dentistry, University of Baghdad, Baghdad, Iraq
چکیده
Amoxicillin is one of the most commonly prescribed antibiotics in children. As a result, it is prescribed as the first line of defence against cutaneous, gastrointestinal, and respiratory infections. The objective of this study was to evaluate the effects of Amoxicillin on the formation of dentin and enamel during the secretory and early phases of mineralization. Regarding the materials and methods used to perform this study, 16 pregnant adult Wistar rats were equally divided into two groups. The first group did not receive the drug and was prescribed a saline solution (control group), and the other group received 250 mg/kg/day of Amoxicillin (experimental group). From the 13th gestational day until delivery, the treatment was given every day by oral gavage. After birth, the newborns also received the same treatment as their mothers from the first day until 7 or 12 days after birth. The newborns were sacrificed at 7 and 12 days postnatally, the jaws were dissected, the maxilla was taken, the samples were fixed in 10% formaldehyde solution, and the upper first molars were analyzed histologically by H & E stain and histomorphometrically by image J to examine the enamel, dentin, ameloblast and odontoblast mean thickness in both groups and each healing periods. The study's results showed that the mean enamel, as well as ameloblastic and odontoblastic layer thickness, were significantly different in the Amoxicillin 250 mg/kg group, compared to the control group. The result also revealed a non-significant group difference in the dentin thickness in both durations (P-value at day 7=0.147 and the P-value at day 12=0.054). Vacuolization of the ameloblastic and odontoblastic layers was observed in the Amoxicillin-treated group in both durations.
کلیدواژه‌ها
Amoxicillin؛ Enamel؛ Dentin؛ Vacuolization؛ Ameloblast
سایر فایل های مرتبط با مقاله
مراجع
  1. Whitlock JA, Richman JM. Biology of tooth replacement in amniotes. Int J Oral Sci. 2013;5(2):66-70.
  2. Ahmed GM, Abouauf EA, AbuBakr N, Dörfer CE, El-Sayed KF. Tissue engineering approaches for enamel, dentin, and pulp regeneration: an update. Stem Cells Int. 2020;2020.
  3. Matalová E, Lungová V, Sharpe P. Development of tooth and associated structures. Stem cell biology and tissue engineering in dental sciences: Elsevier; 2015. p. 335-46.
  4. Fehrenbach MJ, Popowics T. Illustrated Dental Embryology, Histology, and Anatomy E-Book: Elsevier Health Sciences; 2019.
  5. Kawashima N, Okiji T. Odontoblasts: Specialized hard‐tissue‐forming cells in the dentin‐pulp complex. Congenit Anom. 2016;56(4):144-53.
  1. Hasoon SL, Al-Ghaban NM. The effects of bisphosphonate administration on teeth development and growth of the jaw bones in neonatal rats (histological and immunohistochemical study). J Baghdad Coll Dent. 2013;25(Special Is):77-82.
  2. Akhavan BJ, Khanna NR, Vijhani P. Amoxicillin. StatPearls [Internet]: StatPearls Publishing; 2021.
  3. Damkier P, Brønniche LM, Korch-Frandsen JF, Broe A. In utero exposure to antibiotics and risk of congenital malformations: a population-based study. Am J Obstet Gynecol. 2019;221(6):648. e1-. e15.
  4. de Souza JF, Gramasco M, Jeremias F, Santos‐Pinto L, Giovanini AF, Cerri PS, et al. Amoxicillin diminishes the thickness of the enamel matrix that is deposited during the secretory stage in rats. Int J Paediatr Dent. 2016;26(3):199-210.
  5. Mostafa HM, Shehata FI, Omar SO, Kawana KY. The effect of amoxicillin on the secretory stage of amelogenesis in rats. Alex Dent J. 2020;45(1):34-8.
  6. Gottberg B, Berné J, Quiñónez B, Solórzano E. Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats. Med Oral Patol Oral Cir Bucal. 2014;19(1):e38.
  7. Kameli S, Moradi-Kor N, Tafaroji R, Ghorbani R, Farzadmnesh H, Sameni H. Effects of amoxicillin on the structure and mineralization of dental enamel and dentin in wistar rats. Front Dent. 2019;16(2):130.
  8. Sahlberg C, Pavlic A, Ess A, Lukinmaa P-L, Salmela E, Alaluusua S. Combined effect of amoxicillin and sodium fluoride on the structure of developing mouse enamel in vitro. Arch Oral Biol. 2013;58(9):1155-64.
  9. Souza J, Costa-Silva C, Jeremias F, Santos-Pinto L, Zuanon ACC, Cordeiro RdC. Molar incisor hypomineralisation: possible aetiological factors in children from urban and rural areas. Eur Arch Paediatr Dent. 2012;13(4):164-70.
  10. Serna C, Vicente A, Finke C, Ortiz AJ. Drugs related to the etiology of molar incisor hypomineralization: a systematic review. J Am Dent Assoc. 2016;147(2):120-30.
  11. Kumazawa K, Sawada T, Yanagisawa T, Shintani S. Effect of single-dose amoxicillin on rat incisor odontogenesis: a morphological study. Clin Oral Investig. 2012;16(3):835-42.
آمار
تعداد مشاهده مقاله: 2,186
تعداد دریافت فایل اصل مقاله: 335


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب