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Aghazadeh, Hamed, Rigi, Amir, Sangchooli, Tahereh, Taheri, Parastoo, Nasiraei, Amir Hossein, Mohammadi, Mohadese. (1402). A New Herbal Medicine Formulation with Potential Anti-scabies Properties to Treat Demodex and Sarcoptes Parasites. سامانه مدیریت نشریات علمی, 78(5), 1472-1482. doi: 10.32592/ARI.2023.78.5.1472
Hamed Aghazadeh; Amir Rigi; Tahereh Sangchooli; Parastoo Taheri; Amir Hossein Nasiraei; Mohadese Mohammadi. "A New Herbal Medicine Formulation with Potential Anti-scabies Properties to Treat Demodex and Sarcoptes Parasites". سامانه مدیریت نشریات علمی, 78, 5, 1402, 1472-1482. doi: 10.32592/ARI.2023.78.5.1472
Aghazadeh, Hamed, Rigi, Amir, Sangchooli, Tahereh, Taheri, Parastoo, Nasiraei, Amir Hossein, Mohammadi, Mohadese. (1402). 'A New Herbal Medicine Formulation with Potential Anti-scabies Properties to Treat Demodex and Sarcoptes Parasites', سامانه مدیریت نشریات علمی, 78(5), pp. 1472-1482. doi: 10.32592/ARI.2023.78.5.1472
Aghazadeh, Hamed, Rigi, Amir, Sangchooli, Tahereh, Taheri, Parastoo, Nasiraei, Amir Hossein, Mohammadi, Mohadese. A New Herbal Medicine Formulation with Potential Anti-scabies Properties to Treat Demodex and Sarcoptes Parasites. سامانه مدیریت نشریات علمی, 1402; 78(5): 1472-1482. doi: 10.32592/ARI.2023.78.5.1472

A New Herbal Medicine Formulation with Potential Anti-scabies Properties to Treat Demodex and Sarcoptes Parasites

Archives of Razi Institute
مقاله 10، دوره 78، شماره 5، آذر و دی 2023، صفحه 1472-1482    اصل مقاله (820.33 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.5.1472
نویسندگان
Hamed Aghazadeh* 1؛ Amir Rigi2؛ Tahereh Sangchooli3؛ Parastoo Taheri4؛ Amir Hossein Nasiraei5؛ Mohadese Mohammadi6
1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2Young Researchers and Elites Club, Islamic Azad University, Zahedan Branch, Zahedan, Iran
3Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran
4Department of Pharmaceutical Engineering, Faculty of Chemical Engineering, University of Tehran, Tehran, Iran
5Department of Veterinary Medicine, Faculty of Veterinary Medicine, Islamic Azad University, Garmsar Branch, Garmsar, Iran
6Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
چکیده
Scabies is considered an external parasite notorious for its high prevalence causing severe and contagious skin lesions in humans and animals worldwide. This study has introduced a medicine to treat dogs infested with scabies (variants of Demodex, Sarcoptes, Psoroptes, Otodectes, etc.). The present study offers a no-side-effect herbal formulation to treat dogs infested with scabies. Unlike oral and injectable medicines, which take the form of an ointment and are topically applied on-site, this medicinal formulation can be easily used without concerns over its side effects or consumption dosages. This medicinal formulation requires no skin rinsing due to its herbal and high skin absorption properties, as recovery may take less than a month with a maximum of two times of application. To carry out the experiment, 25 sick dogs with various breeds and ages suspected of scabies were gathered. Following accurate morphological examinations of all the samples, a deep skin chip of the lesion site was provided, which was examined by a microscope. Then, 13 dogs (Mix, Terrier, Pug, Husky, Spitz) were infested with Demodex scabies and 12 dogs (Pittbull, Mix, Shih Tzu, Terrier, Boxer, Setter) with Sarcoptic scabies. The prepared product was topically administered at a constant 2% dosage to the bodies of all the samples. To prepare the ointment, 1 g of Borax (Na₂B₄O₇·10H₂O) was first dissolved in 35 g deionized water and heated to 70°C. Then, 45 g of liquid paraffin (CnH2n+2) was mixed with 1 g of Carvacrol (C10H14O) and 1 g of geranium (C10H18O) and stirred well to become a phase. Later, 17 g of the melted beeswax (C15H31COOC30H61) was added to the liquid paraffin compound. In the end, the aqueous phase was added to the oil phase, and the mixture process immediately began in one direction with a glass stirrer and continued until the product cooled down. Essential oils (EO) was obtained by steam distillation of fresh Thyme and Rose-Acented Geranium in a stainless steel distillation apparatus (alembic) for 3 h. The main components of the essential oils used in the formulation were performed using a Hewlett-Packard GC system interfaced with a mass spectrometer equipped with an HP5-MS capillary column (30 m, 0.32 mm, 0.25 µm film thicknesses). For GC–MS detection, electron ionization with ionization energy of 70 eV was used. To examine the presence of scabies, weekly skin sampling was performed, and the treatment continued until 30 days, when no skin chip of the scabies was noted. The findings revealed that the formulation developed no side effects and removed the daily use, as it could be administered once or twice a week. Also, complete recovery of scabies in all the breeds was found to be less than a month at most. This medicinal formulationcan be easily used without concerns over its side effects or consumption dosages. This study introduced a herbal formulation with effective herbal ingredients without any side effects to treat the sarcoptes and demodex parasites; unlike other chemical compounds, this medicinal formulation has no side effects, while some other formulations could develop side effects.
کلیدواژه‌ها
Anti-scabies؛ Demodex؛ Essential oils (EO)؛ Formulation؛ Sarcoptes؛ Herbal Medicine
عنوان مقاله [English]
فرمولاسیون دارویی جدید گیاهی با خواص بالقوه ضد گال برای درمان انگل های دمودکس (دمودیکوز) و سارکوپتس
سایر فایل های مرتبط با مقاله
مراجع
pharmaceutical company or for-profit organization.
References
1.Beck W, Hora F, Pantchev N. Case series: Efficacy of a
formulation containing selamectin and sarolaner against naturally
acquired mite infestations (Demodex sp, Ornithonyssus bacoti) in
degus (Octodon degus). Vet Parasitol. 2021;293.109430.
Doi:10.1016 j.vetpar.2021.109430.
2.Delaš Aždajić M, Bešlić I, Gašić A, Ferara N, Pedić L, Lugović
Mihić L. Increased Scabies Incidence at the Beginning of the 21st
Century: What Do Reports from Europe and the World Show.
Life (Basel). 2022;12(10),1598. Doi:10.3390/life12101598.
3.Chandler DJ, and Fuller LC. A review of scabies: an infestation
more than skin deep. Dermatology. 2019;235(2),79-90.
Doi:10.1159/000495290.
4.Arora P, Rudnicka L, Sar Pomian M, Wollina U, Jafferany M,
Lotti T, Goldust M. Scabies: a comprehensive review and current
perspectives. Dermatol Ther. 2020;33(4),e13746.
Doi:10.1111/dth.13746
5.Moroni B, Rossi L, Bernigaud C, Guillot J. Zoonotic episodes of
scabies: a global overview. Pathogens. 2022;11(2),213.
Doi:10.3390/pathogens11020213.
6.Pisano SR, Ryser Degiorgis MP, Rossi L, Peano A, Keckeis K,
Roosje P. Sarcoptic mange of fox origin in multiple farm animals
and scabies in humans, Switzerland, 2018. Emerg Infect Dis.
2019;25(6),1235. Doi:10.3201/eid2506.181891.
7.Fourie JJ, Liebenberg JE, Horak IG, Taenzler J, Heckeroth AR,
Frénais R. Efficacy of orally administered fluralaner
(BravectoTM) or topically applied imidacloprid/moxidectin
(Advocate®) against generalized demodicosis in dogs. Parasit
Vectors. 2015;8(1),1-7. Doi:10.1186/s13071-015-0775-8.
8.Manjunathachar HV, Sudhakar NR, Verma R. Pruritic dermatitis
1482 Aghazadeh et al / Archives of Razi Institute, Vol. 78, No. 5 (2023) 1472-1482
in two stray pups due to mixed Demodex and Sarcoptes mite
infestations. International Journal of Tropical Insect Science.
2020;40(4),769-771. Doi:10.1007/s42690-020-00129-4.
9.Pasipanodya CN, Tekedza TT, Chatiza FP, Gororo E. Efficacy of
neem (Azadirachta indica) aqueous fruit extracts against
Sarcoptes scabiei var. suis in grower pigs. Trop Anim Health
Prod. 2021;53(1),1-7. Doi:10.1007/s11250-020-02545-7
10. Paichitrojjana A, Chalermchai T. Comparison of in vitro
Killing Effect of N, N-Diethyl-Meta-Toluamide (DEET) versus
Permethrin on Demodex folliculorum. Clin Cosmet Investig
Dermatol. 2022;15,1301-1307. Doi:10.2147/CCID.S376454.
11. Fourie JJ, Meyer L, and Thomas E. Efficacy of topically
administered fluralaner or imidacloprid/moxidectin on dogs with
generalised demodicosis. Parasit Vectors. 2019;12(1),1-5.
Doi:10.1186/s13071-018-3230-9.
12. Petersen I, Chiummo R, Zschiesche E, Karas Tecza J,
Rapti D, Roepke R, Thomas E. A European field assessment of
the efficacy of fluralaner (Bravecto®) chewable and spot-on
formulations for treatment of dogs with generalized
demodicosis. Parasites & Vectors. 2020;13(1),1-7.
Doi:10.21203/rs.2.19478/v1
13. Wagner R, and Wendlberger U. Field efficacy of
moxidectin in dogs and rabbits naturally infested with Sarcoptes
spp., Demodex spp. and Psoroptes spp. mites. Vet Parasitol.
2000;93(2),149-158. Doi:10.1016/s0304-4017(00)00357-5
14. Sivakumar M, Saravanan M, Yogeshpriya S, Venkatesan
M, Arulkumar KJ, Veeraselvam M, Selvaraj P. Successful
management of Sarcoptes scabiei infestation in a beagle dog.
Journal of entomology and zoology studies. 2017;8,11-3.
15. Thakre BJ, Kumar B, Brahmbhatt NN, Parmar VL, and
Gamit K. Management of scabies in rabbits using ivermectin.
Journal of Veterinary Parasitology. 2020;34(1),69-70.
16. Halliwell REW. The diagnostic approach to pruritus. In
SPONSORS OF THE 8 TH WORLD CONGRESS OF
VETERINARY DERMATOLOGY. 2016;(p. 5).
17. Costa LG, Giordano G, Guizzetti M, and Vitalone A.
Neurotoxicity of pesticides: a brief review. Front Biosci.
2008;13(4),1240-1249. Doi:10.2741/2758
18. Agrawal ANJU, Sharma B. Pesticides induced oxidative
stress in mammalian systems. Int J Biol Med Res. 2010;1(3),90-
104.
19. Mdeni NL, Adeniji AO, Okoh AI, Okoh OO. Analytical
evaluation of carbamate and organophosphate pesticides in
human and environmental matrices: a review. Molecules.
2022;27(3),618. Doi:10.3390/molecules27030618.
20. Isoletta E, Vassallo C, Brazzelli V, Giorgini C, Tomasini
CF, Sabena A, Barruscotti S. Emergency accesses in
Dermatology Department during the Covid‐ 19 pandemic in a
referral third level center in the north of Italy. Dermatol Ther.
2020;33(6),e14027. Doi:10.1111/dth.14027.
21. Aghazadeh H, Tamaddon F, Ouni M, Taheri P,
Sangchooli T. Microencapsulation of herbal bioactive drug by
Chlorella Vulgaris microalgae as a nano-formulation for drug
delivery to cells. Eurasian Chemical Communications.
2023;5(4):327-334. Doi:10.22034/ecc.2023.370804.1558.
22. Aghazadeh H, Taheri P, Hassani S, Sangchooli T, Ouni
M, Asghari N. Vancomycin prolonged release via PLGA system
loaded with drug-containing chitosan nanoparticles as a novel in
situ forming drug delivery system. Eurasian Chemical
Communications. 2023;5(5):392-403.
Doi:10.22034/ecc.2023.377911.1580.
23. Asghari N, Houshmand S, Rigi A, Mohammadzadeh V,
Piri Dizaj M, Mousavian Hiagh ZS. PEGylated cationic nanoniosomes formulation containing herbal medicine curcumin for
drug delivery to MCF-7 breast cancer cells. Eurasian Chemical
Communications. 2023;5(6):556-568.
Doi:10.22034/ecc.2023.381375.1592.
24. Naresh R, Swarup D, Sharma MC, Ranjan R. Clinical
management of sarcoptic mange in Indian buffalo calves with a
botanical ointment. Vet Rec. 2005;156(21),684-685.
Doi:10.1136/vr.156.21.684
25. Wagner R, Wendlberger U. Field efficacy of moxidectin
in dogs and rabbits naturally infested with Sarcoptes spp.,
Demodex spp. and Psoroptes spp. mites. Vet Parasitol.
2000;93(2),149-158. Doi:10.1016/s0304-4017(00)00357-5
26. Chen Z, van Mol W, Vanhecke M, Duchateau L,
Claerebout E. Acaricidal activity of plant-derived essential oil
components against Psoroptes ovis in vitro and in vivo. Parasit
Vectors. 2019;12(1),1-11. Doi:10.1186/s13071-019-3654-x
27. Petersen I, Chiummo R, Zschiesche E, Karas Tecza J,
Rapti D, Roepke R, Thomas E. A European field assessment of
the efficacy of fluralaner (Bravecto®) chewable and spot-on
formulations for treatment of dogs with generalized demodicosis.
Parasit Vectors. 2020;13(1),1-7. Doi:10.21203/rs.2.19478/v1
28. Li M, Liu S, Yin Z, Bernigaud C, Guillot J, Fang F.
Activity of terpenes derived from essential oils against Sarcoptes
scabiei eggs. Parasit Vectors. 2021;14(1),1-6.
Doi:10.1186/s13071-021-05094-6
29. Naresh R, Swarup D, Sharma MC, Ranjan R. Clinical
management of sarcoptic mange in Indian buffalo calves with a
botanical ointment. Vet Re. 2005;156(21),684-685.
Doi:10.1136/vr.156.21.6

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