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Zokaei, L, Akbari, E, Babapour, V, Zendehdel, M. (1402). The Modulatory Role of Orexin 1 Receptor in Nucleus Accumbens (NAc) on Spatial Memory in Rats. سامانه مدیریت نشریات علمی, 78(4), 1285-1294. doi: 10.32592/ARI.2023.78.4.1285
L Zokaei; E Akbari; V Babapour; M Zendehdel. "The Modulatory Role of Orexin 1 Receptor in Nucleus Accumbens (NAc) on Spatial Memory in Rats". سامانه مدیریت نشریات علمی, 78, 4, 1402, 1285-1294. doi: 10.32592/ARI.2023.78.4.1285
Zokaei, L, Akbari, E, Babapour, V, Zendehdel, M. (1402). 'The Modulatory Role of Orexin 1 Receptor in Nucleus Accumbens (NAc) on Spatial Memory in Rats', سامانه مدیریت نشریات علمی, 78(4), pp. 1285-1294. doi: 10.32592/ARI.2023.78.4.1285
Zokaei, L, Akbari, E, Babapour, V, Zendehdel, M. The Modulatory Role of Orexin 1 Receptor in Nucleus Accumbens (NAc) on Spatial Memory in Rats. سامانه مدیریت نشریات علمی, 1402; 78(4): 1285-1294. doi: 10.32592/ARI.2023.78.4.1285

The Modulatory Role of Orexin 1 Receptor in Nucleus Accumbens (NAc) on Spatial Memory in Rats

Archives of Razi Institute
مقاله 15، دوره 78، شماره 4، مهر و آبان 2023، صفحه 1285-1294    اصل مقاله (568.79 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.4.1285
نویسندگان
L Zokaei1؛ E Akbari* 2، 3؛ V Babapour4؛ M Zendehdel4
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
چکیده
Neuropeptide orexin mainly exists in neurons within and around the lateral hypothalamus and exhibits high affinity to orexin 1 and 2 receptors (OX1R and OX2R, respectively). Orexinergic neurons send their axons to the nucleus accumbens (NAc), which expresses OX1Rs. Previous studies have shown the involvement of orexins and their role in learning and memory processes in the dorsal raphe nucleus and hippocampus. However, no study has examined the effects of orexins in the NAc on memory. The present study examined the effect of the post-training and pre-probe trial intra-NAc administration of SB-33486-A (OX1R antagonist, 12 μg/0.5μl) and TCS-OX2-29 (OX2R antagonist, 10 μg/0.5 μl) on the consolidation and retrieval of memory in the Morris Water Maze (MWM) task. In experiment 1, rats were trained in the MWM and, immediately after every training, received bilateral injections of dimethyl sulfoxide (DMSO) (control group), SB-334867-A (SB), and TCS-OX2-29 (TCS) into the NAc. Experiment 2 was similar to experiment 1, except that the rats received DMSO, SB, and TCS 15 min before the probe test. Probe and visible tests were performed after the last training, and the distance moved, escape latency, and velocity were recorded. In experiment 3, rats trained in experiments 1 and 2, immediately after the probe test, were given the trials for visuomotor coordination assessment on the visible platform. According to the results, the injection of SB increased the distance moved and escape latency in the treated groups, compared to the control group, in the consolidation phase of spatial memory (P<0.05) but not in its retrieval phase (P>0.05). However, TCS-OX2-29 had no effect. These results suggest that the inactivation of the NAc OX1Rs, but not OX2Rs, impairs the consolidation but not the retrieval of spatial memory in rats.
کلیدواژه‌ها
Memory؛ Nucleus accumbens؛ Orexin receptors
عنوان مقاله [English]
نقش میانجیگری گیرنده های اورکسینی 1 در هسته آکومبنس بر حافظه فظایی در رت ها
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