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J. Taher, Hataw, H. Kamel, Fouad. (1401). Prevalence and phylogenetic analysis of Fusobacterium nucleatum and its virulent factor FadA among ulcerative colitis precancerous and colorectal carcinoma patients in Iraqi Kurdish population. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.360307.2570
Hataw J. Taher; Fouad H. Kamel. "Prevalence and phylogenetic analysis of Fusobacterium nucleatum and its virulent factor FadA among ulcerative colitis precancerous and colorectal carcinoma patients in Iraqi Kurdish population". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.360307.2570
J. Taher, Hataw, H. Kamel, Fouad. (1401). 'Prevalence and phylogenetic analysis of Fusobacterium nucleatum and its virulent factor FadA among ulcerative colitis precancerous and colorectal carcinoma patients in Iraqi Kurdish population', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.360307.2570
J. Taher, Hataw, H. Kamel, Fouad. Prevalence and phylogenetic analysis of Fusobacterium nucleatum and its virulent factor FadA among ulcerative colitis precancerous and colorectal carcinoma patients in Iraqi Kurdish population. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.360307.2570

Prevalence and phylogenetic analysis of Fusobacterium nucleatum and its virulent factor FadA among ulcerative colitis precancerous and colorectal carcinoma patients in Iraqi Kurdish population

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 آذر 1401  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360307.2570
نویسندگان
Hataw J. Taher email 1؛ Fouad H. Kamel2
1Department of Medical Laboratory Technology, Erbil Health and Medical Technical College, Erbil Polytechnic University, Erbil, Iraq. https://orcid.org/0000-0003-3393-9818
2Department of Medical Laboratory Technology, Medical Technical Institute, Erbil Polytechnic University, Erbil, Iraq. https://orcid.org/0000-0001-9200
چکیده
Fusobacterium nucleatum is considered as one of the main risk factors that play key role in promotion and progression of colorectal carcinoma. The main goal of this study is find out the association between the prevalence of various subtypes Fusobacterium nucleatum with inflammation and colorectal cancer progression, in addition to screening the positive ratio of the possession of FadA gene. One hundred tissue samples were collected from healthy individuals and patients from colonoscopy and surgical operation biopsies. The patients categorized into (Ulcerative colitis, precancerous colitis and colorectal carcinoma) according to their colonoscopy and histopathology examination reports. Molecular detection of Fusobacterium nucleatum and FadA gene were performed via PCR and gel electrophoresis, then phylogenetic analysis for Fusobacterium nucleatum was done using 16S rRNA partial sequencing based on specific primers. The results showed significant differences among the four groups regarding the prevalence of Fusobacterium nucleatum. The most prevalent subtype was Fusobacterium nucleatum subtype animalis which constitutes 7 out 17 samples. The ratio of FadA positive gene was 20% among the Fusobacterium nucleatum positive cases. This finding suggested strong correlation between Fusobacterium nucleatum and colon inflammation and cancer progression steps, and Fusobacterium nucleatum subtype animalis was the most prevalent subtype.
کلیدواژه‌ها
Prevalence and phylogenetic analysis؛ of Fusobacterium nucleatum and؛ its virulent factor FadA among ulcerative colitis precancerous and colorectal carcinoma patients in Iraqi Kurdish population
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تعداد مشاهده مقاله: 34


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