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Khosravi-Nezhad, Sh, Hassanpour, Sh, Hesaraki, S. (1401). L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice. سامانه مدیریت نشریات علمی, 78(1), 195-203. doi: 10.22092/ari.2022.360066.2544
Sh Khosravi-Nezhad; Sh Hassanpour; S Hesaraki. "L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice". سامانه مدیریت نشریات علمی, 78, 1, 1401, 195-203. doi: 10.22092/ari.2022.360066.2544
Khosravi-Nezhad, Sh, Hassanpour, Sh, Hesaraki, S. (1401). 'L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice', سامانه مدیریت نشریات علمی, 78(1), pp. 195-203. doi: 10.22092/ari.2022.360066.2544
Khosravi-Nezhad, Sh, Hassanpour, Sh, Hesaraki, S. L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice. سامانه مدیریت نشریات علمی, 1401; 78(1): 195-203. doi: 10.22092/ari.2022.360066.2544

L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice

Archives of Razi Institute
مقاله 26، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 195-203    اصل مقاله (759.54 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360066.2544
نویسندگان
Sh Khosravi-Nezhad1؛ Sh Hassanpour* 2؛ S Hesaraki1
1Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
This study designed to investigate the protective effects of L-theanine on experimental Multiple sclerosis in mice. Frothy Male C57BL/6 mice were allocated into 4 experimental groups: control no treatment received a regular chew pellet, and the cuprizone (CPZ) group received a standard chew pellet containing 0.2% (w/w) CPZ. In group 3, mice were fed a regular diet and administered p.o. with L-theanine (50 mg/kg). In group 4, mice received a diet containing CPZ and were administered p.o. with L-theanine (50mg/kg). Finally, reflexive motor behavior and serum antioxidant levels were determined. Based on findings, CPZ significantly decreased ambulation score, hind-limb suspension, front limb suspension, and grip strength (P<0.05). The CPZ+L-theanine reduced the adverse effect of the CPZ on ambulation score, hind-limb foot angle, surface righting, and negative geotaxis (P<0.05). The CPZ+L-theanine increased front and hind-limb suspension, grip strength, number of the cross, and duration of a stay on the rotarod compared to the control animal (P<0.05). CPZ administration significantly elevated serum malondialdehyde (MDA) while superoxide dismutase (SOD) and glutathione peroxidase (GPx) and total antioxidant status (TAS) levels decreased compared to control mice (P<0.05). The CPZ+L-theanine leads to the cessation of MDA production while increasing SOD, GPx, and TAS levels (P<0.05). These results suggested L-theanine has a protective effect against CPZ-induced MS in mice.
کلیدواژه‌ها
Antioxidant؛ L-theanine؛ Multiple sclerosis؛ Mice
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مراجع
  1. Zhu X, Yao Y, Hu Y, Yang J, Zhang C, He Y, et al. Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. Neurobiol Dis. 2021;158:105489.
  2. Jones CD, Motl R, Sandroff BM. Depression in multiple sclerosis: Is one approach for its management enough? Mult Scler Relat Disord. 2021;51:102904.
  3. Haider L, Zrzavy T, Hametner S, Hoftberger R, Bagnato F, Grabner G, et al. The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain. Brain. 2016;139(Pt 3):807-15.
  4. Panat NA, Maurya DK, Ghaskadbi SS, Sandur SK. Troxerutin, a plant flavonoid, protects cells against oxidative stress-induced cell death through radical scavenging mechanism. Food Chem. 2016;194:32-45.
  5. Ali Hemmati Ar, Hatami H, Khajehnasiri N. 17-β estradiol Attenuated Hippocampus Oxidative Stress in an Ethidium Bromide-Induced Multiple Sclerosis Model among Adult Male Rats. Ilam-University-of-Medical-Sciences. 2019;26(6):205-14.
  6. Khalilian B, Madadi S, Fattahi N, Abouhamzeh B. Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis. J Mol Histol. 2021;52(1):125-34.
  7. Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10).
  8. Saeed M, Khan MS, Kamboh AA, Alagawany M, Khafaga AF, Noreldin AE, et al. L-theanine: an astounding sui generis amino acid in poultry nutrition. Poult Sci. 2020;99(11):5625-36.
  9. Fu X, Liao Y, Cheng S, Xu X, Grierson D, Yang Z. Nonaqueous fractionation and overexpression of fluorescent-tagged enzymes reveals the subcellular sites of L-theanine biosynthesis in tea. Plant Biotechnol J. 2021;19(1):98-108.
  10. Kiasalari Z, Rahmani T, Mahmoudi N, Baluchnejadmojarad T, Roghani M. Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation. Biomed Pharmacother. 2017;86:654-61.
  11. Ye H, Liu Z, Zhou L, Cai Q. Dynamic Observation of the Effect of L-Theanine on Cerebral Ischemia-Reperfusion Injury Using Magnetic Resonance Imaging under Mathematical Model Analysis. J Healthc Eng. 2021;2021:5679665.
  12. Williams E, Scott JP. The Development of Social Behavior Patterns in the Mouse, in Relation To Natural Periods 1) %J Behaviour. 1954;6(1):35-64.
  13. Feather-Schussler DN, Ferguson TS. A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy. J Vis Exp. 2016(117).
  14. Heyser CJ. Assessment of developmental milestones in rodents. Curr Protoc Neurosci. 2004.
  15. Corti S. Grip strength. J Experimental protocols for SMA animal models, TREAT-NMD. 2017.
  16. Venerosi A, Ricceri L, Scattoni ML, Calamandrei G. Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups. Environ Health. 2009;8:12.
  17. Donato F, de Gomes MG, Goes AT, Filho CB, Del Fabbro L, Antunes MS, et al. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels. Brain Res Bull. 2014;104:19-26.
  18. Eltokhi A, Kurpiers B, Pitzer C. Comprehensive characterization of motor and coordination functions in three adolescent wild-type mouse strains. Sci Rep. 2021;11(1):6497.
  19. Zendedel A, Beyer C, Kipp M. Cuprizone-induced demyelination as a tool to study remyelination and axonal protection. J Mol Neurosci. 2013;51(2):567-72.
  20. Nguyen AT, Armstrong EA, Yager JY. Neurodevelopmental reflex testing in neonatal rat pups. J JoVE. 2017(122):e55261.
  21. Semple BD, Blomgren K, Gimlin K, Ferriero DM, Noble-Haeusslein LJ. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol. 2013;106-107:1-16.
  22. Ojha S. In vitro and In vivo neuroprotective study of solid lipid nanoparticles loaded with dimethyl fumarate. J Asian Journal of Pharmaceutics. 2018;12(01).
  23. Shamsi-Gamchi N, Razi M, Behfar M. Testicular torsion and reperfusion: evidences for biochemical and molecular alterations. Cell Stress Chaperones. 2018;23(3):429-39.
  24. Samad N, Jabeen S, Imran I, Zulfiqar I, Bilal K. Protective effect of gallic acid against arsenic-induced anxiety-/depression- like behaviors and memory impairment in male rats. Metab Brain Dis. 2019;34(4):1091-102.
  1. Suleghani M, Asghari A, Hassanpour S, Jahandideh A. The effect of l-theanine administration on testicular ischemia/reperfusion injury in the rat. Journal of Basic and Clinical Pathophysiology. 2022;10(1):17-24.
  2. Yamada T, Terashima T, Wada K, Ueda S, Ito M, Okubo T, et al. Theanine, r-glutamylethylamide, increases neurotransmission concentrations and neurotrophin mRNA levels in the brain during lactation. Life Sci. 2007;81(16):1247-55.
  3. Zukhurova M, Prosvirnina M, Daineko A, Simanenkova A, Petrishchev N, Sonin D, et al. L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. Phytother Res. 2013;27(9):1282-7.
  4. Miodownik C, Maayan R, Ratner Y, Lerner V, Pintov L, Mar M, et al. Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients. Clin Neuropharmacol. 2011;34(4):155-60.
  5. Yin C, Gou L, Liu Y, Yin X, Zhang L, Jia G, et al. Antidepressant-like effects of L-theanine in the forced swim and tail suspension tests in mice. Phytother Res. 2011;25(11):1636-9.
  6. Wu Y, Shen M, Lu W, Tang H, Wu H, Zhang B, et al. L-theanine improves depressive behavioral deficits by suppressing microglial activation in a rat model of chronic unpredictable mild stress. Int J Clin Exp Med. 2017;10:4809-18.
  7. Ogawa S, Ota M, Ogura J, Kato K, Kunugi H. Effects of L-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wistar Kyoto rats. Psychopharmacology (Berl). 2018;235(1):37-45.
  8. Lu L, Wu D, Wang K, Tang J, Chen G. Beneficial Effects of Crocin against Depression via Pituitary Adenylate Cyclase-Activating Polypeptide. Biomed Res Int. 2020;2020:3903125.
  9. Tavassolifar MJ, Vodjgani M, Salehi Z, Izad M. The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis. Autoimmune Dis. 2020;2020:5793817.
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