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fazlelahi, zohreh, Kaboutari, Jahangir, zendehdel, morteza, panahi, negar. (1401). Effects of intracerebroventricular injection of the steroidal and non-steroidal anti-inflammatory drugs on seizures during the estrous cycle in rat. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.360115.2553
zohreh fazlelahi; Jahangir Kaboutari; morteza zendehdel; negar panahi. "Effects of intracerebroventricular injection of the steroidal and non-steroidal anti-inflammatory drugs on seizures during the estrous cycle in rat". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.360115.2553
fazlelahi, zohreh, Kaboutari, Jahangir, zendehdel, morteza, panahi, negar. (1401). 'Effects of intracerebroventricular injection of the steroidal and non-steroidal anti-inflammatory drugs on seizures during the estrous cycle in rat', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.360115.2553
fazlelahi, zohreh, Kaboutari, Jahangir, zendehdel, morteza, panahi, negar. Effects of intracerebroventricular injection of the steroidal and non-steroidal anti-inflammatory drugs on seizures during the estrous cycle in rat. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.360115.2553

Effects of intracerebroventricular injection of the steroidal and non-steroidal anti-inflammatory drugs on seizures during the estrous cycle in rat

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 مهر 1401  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360115.2553
نویسندگان
zohreh fazlelahi1؛ Jahangir Kaboutari email orcid 2؛ morteza zendehdelorcid 3؛ negar panahiorcid 1
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary medicine, Shahrekord University
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
چکیده
Because of the mutual relationship between neural infalmation and seizures, this study aimed to determine the effects of ICV injection of the steroidal and non-steroidal anti-inflammatory drugs on PTZ induced seizures during the estrous cycle in the Rat. 105 adult female Wistar rats in 7 groups including control (saline), Ketorolac (7.5,15 & 30 µg), Methylprednisolone acetate (0.15, 0.3 & 0.6 µg), each with 4 subgroups (proestrus, estrus, metestrus & diestrus) in 3 replicates were used (n =5). After a week of acclimatization, estrous phase determination and synchronization were done. Acute epilepsy was inspired by intraperitoneal (i.p) injection of 80 mg/kg of Pentylentetrazol (PTZ), 30 minutes after ICV injection of ketorolac and prednisolone. Initiation time of myoclonic seizures (ITMS), initiation time of tonic-clonic seizures (ITTS), seizures duration (SD) and mortality rate (MR) were accounted for 30 minutes. Data were showed as mean ± SD and analyzed by using One-way ANOVA followed by Tukey–Kramer multiple comparison post hoc test (P<0.05). According to the results, Ketorolac (15 & 30 µg) and Methylprednisolone acetate (0.3 & 0.6 µg) significantly increased the ITTS and ITMS meanwhile decreased seizure duration, during the estrous cycle compared to the control (P <0.05). Also Mortality rate and sezire duration were significantly decreased by Ketorolac (7.5, 15& 30 µg) and Methylprednisolone (0.3 & 0.6 µg) compared to the control during the estrous cycle (P <0.05). so it seems that both Ketorolac and Methylprednisolone possess dose dependent anticonvulsant effects may be by decreasidng neural inflammation.
کلیدواژه‌ها
ICV؛ Methylprednisolone acetate؛ Ketorolac tris salt؛ Seizure؛ Rat
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