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Q. TUAMA, MALAK, N. Ibrahim, Wijdan, SHARIEF, MAYSOON. (1401). Correlation of estrogen receptor alpha serum level with gene polymorphism and its effect on women with unexplained infertility, Basra, Iraq.. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.359863.2490
MALAK Q. TUAMA; Wijdan N. Ibrahim; MAYSOON SHARIEF. "Correlation of estrogen receptor alpha serum level with gene polymorphism and its effect on women with unexplained infertility, Basra, Iraq.". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.359863.2490
Q. TUAMA, MALAK, N. Ibrahim, Wijdan, SHARIEF, MAYSOON. (1401). 'Correlation of estrogen receptor alpha serum level with gene polymorphism and its effect on women with unexplained infertility, Basra, Iraq.', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.359863.2490
Q. TUAMA, MALAK, N. Ibrahim, Wijdan, SHARIEF, MAYSOON. Correlation of estrogen receptor alpha serum level with gene polymorphism and its effect on women with unexplained infertility, Basra, Iraq.. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.359863.2490

Correlation of estrogen receptor alpha serum level with gene polymorphism and its effect on women with unexplained infertility, Basra, Iraq.

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 شهریور 1401  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359863.2490
نویسندگان
MALAK Q. TUAMA email 1؛ Wijdan N. Ibrahim1؛ MAYSOON SHARIEF2
1Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq.
2Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq
چکیده
Females having infertility of unknown etiology are considered significant medical and health problems. This study focused on the role of the ESR alpha gene polymorphism PvuII (rs2234693) and its effect on the amount of ESR alpha in the blood of women who cannot get pregnant for no known reason. A total of 184 females were evaluated, including 102 with unexplained infertility and 82 age-matched control females (with at least one live child with no history of infertility). Blood samples were collected, genomic DNA was isolated from blood samples, and genotyping of the ESR1 gene was performed using polymerase chain reaction-restriction fragment length polymorphism. An ELISA assay assessed ESR alpha expression levels. The study revealed that the mean serum value (ESR) was significantly higher in the case group than in the control group (P <0. 05). The genotypes (TT, TC, CC) and alleles (T, C) significantly influenced the plasma level of ER alpha in the study population. The presence of the C allele was considered a risk factor, and polymorphism had an appositive effect on ESR alpha expression levelin unexplained infertility in women.
کلیدواژه‌ها
RFLP؛ estrogen receptor alpha؛ female infertility؛ gene polymorphism؛ genotyping
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تعداد مشاهده مقاله: 92


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