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Jasib Habeeb, Y, Mohammed Selman, S, Jeafer Mehrath, A. (1401). Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats. سامانه مدیریت نشریات علمی, 77(4), 1503-1511. doi: 10.22092/ari.2022.357642.2082
Y Jasib Habeeb; S Mohammed Selman; A Jeafer Mehrath. "Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats". سامانه مدیریت نشریات علمی, 77, 4, 1401, 1503-1511. doi: 10.22092/ari.2022.357642.2082
Jasib Habeeb, Y, Mohammed Selman, S, Jeafer Mehrath, A. (1401). 'Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats', سامانه مدیریت نشریات علمی, 77(4), pp. 1503-1511. doi: 10.22092/ari.2022.357642.2082
Jasib Habeeb, Y, Mohammed Selman, S, Jeafer Mehrath, A. Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats. سامانه مدیریت نشریات علمی, 1401; 77(4): 1503-1511. doi: 10.22092/ari.2022.357642.2082

Study of the Effects of Cordia myxa Fruit Extract on Induced Animal Model of Depression in Male Rats

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مقاله 26، دوره 77، شماره 4، مهر و آبان 2022، صفحه 1503-1511    اصل مقاله (436.14 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357642.2082
نویسندگان
Y Jasib Habeeb* 1؛ S Mohammed Selman1؛ A Jeafer Mehrath2
1Department of Pharmacology, College of Medicine, University of Babylon, Babel, Iraq
2Department of Biochemistry, College of Medicine, University of Babylon, Babel, Iraq
چکیده
Depression is one of the most common mental illnesses. Herbal medications such as ginseng and peony have recently gained popularity in treating depression due to their safety, efficacy, and cost-effectiveness. Therefore, the present study aimed to evaluate the actions of Cordia myxa (C. myxa) fruit extract on the model of chronic unpredictable mild stress (CUMS) and antioxidant enzymes system in male rats' brains. Sixty male rats were divided into six groups (n=10). Group 1 (control) was neither exposed to CUMS nor received any treatment, while group 2 was exposed to CUMS for 24 days with normal saline treatment for 14 days, group 3 was exposed to CUMS for 24 days and received 10 mg/kg fluoxetine daily on day 10 for 14 days, and group 4, 5, and 6 were exposed to CUMS for 24 days and received C. myxa extract (125, 250, and 500 mg/kg, respectively) on day 10 for 14 days. The antidepressant effect of fluoxetine and C. myxa extract was evaluated using a forced swim test (FST). At the end of the experiments, animals were sacrificed by decapitation; and antioxidant enzyme levels, catalase (CAT), and superoxide dismutase (SOD) were determined by enzyme-linked immunosorbent assays kits (ELISA) on rats’ brain tissues. All groups subjected to CUMS showed a significant rise in duration of immobility on the tenth day compared to day zero. The CUMS showed a decrease in antioxidant enzyme levels, and groups treated with extract showed significant rise in enzyme levels (SOD and CAT) compared to group 2. According to this recent study, C. myxa may have an antidepressant-like action.
کلیدواژه‌ها
Chronic unpredictable mild stress؛ Depression؛ Cordia myxa؛ Superoxide dismutase؛ Catalase؛ Antioxidant enzyme system
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مراجع
  1. Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annu Rev Public Health. 2013;34:119-38.
  2. Munoz RF, Cuijpers P, Smit F, Barrera AZ, Leykin Y. Prevention of major depression. Annu Rev Clin Psychol. 2010;6:181-212.
  3. James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789-858.
  4. Fu CM, Parahoo K. Causes of depression: perceptions among people recovering from depression. J Adv Nurs. 2009;65(1):101-9.
  5. Shen M, Yang Y, Wu Y, Zhang B, Wu H, Wang L, et al. L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions. Phytother Res. 2019;33(2):412-21.
  6. Mullen S. Major depressive disorder in children and adolescents. Ment Health Clin. 2018;8(6):275-83.
  7. Salimimoghadam S, Ashrafi A, Kianidehkordi F, Najafzadehvarzi H. Hypoglycemic, antitussive and analgesic effects of nanoparticles of Cordia myxa fruits extract. Int J Pharm Investig. 2019;9(4):205-9.
  8. Shahriari M, Moghadamnia D. Protective Effect of Cordia Myxa Extract on Changes in Body Weight, Serum Proteins, Albumin and Liver Histology of Adult Male Rats Induced by Cadmium Chloride Toxicity. Iran J Toxicol. 2019;13(2):43-9.
  9. Amiresmaeili A, Roohollahi S, Mostafavi A, Askari N. Effects of oregano essential oil on brain TLR4 and TLR2 gene expression and depressive-like behavior in a rat model. Res Pharm Sci. 2018;13(2):130-41.
  10. Cryan JF, Valentino RJ, Lucki I. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev. 2005;29(4-5):547-69.
  11. Zhang Y, Wang Y, Lei H, Wang L, Xue L, Wang X, et al. Optimized animal model to mimic the reality of stress-induced depression in the clinic. BMC Psychiatry. 2017;17(1):171.
  12. Wang D, An SC, Zhang X. Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor. Neurosci Lett. 2008;433(1):59-64.
  13. Rahman I, Marwick J, Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem Pharmacol. 2004;68(6):1255-67.
  14. Liu Q, Li B, Zhu HY, Wang YQ, Yu J, Wu GC. Glia atrophy in the hippocampus of chronic unpredictable stress-induced depression model rats is reversed by electroacupuncture treatment. J Affect Disord. 2011;128(3):309-13.
  15. Giudicessi JR, Ackerman MJ. Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes. Transl Res. 2013;161(1):1-14.
  16. Rai A, Gill M, Kinra M, Shetty R, Krishnadas N, Rao CM, et al. Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress. Biomed Rep. 2019;11(2):79-84.
  17. Hu M, Zou W, Wang CY, Chen X, Tan HY, Zeng HY, et al. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. Oxid Med Cell Longev. 2016;2016:2153745.
  18. Chopra K, Kumar B, Kuhad A. Pathobiological targets of depression. Expert Opin Ther Targets. 2011;15(4):379-400.
  19. Lucca G, Comim CM, Valvassori SS, Reus GZ, Vuolo F, Petronilho F, et al. Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm. J Psychiatr Res. 2009;43(9):864-9.
  1. Sanacora G, Treccani G, Popoli M. Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology. 2012;62(1):63-77.
  2. Moretti M, Colla A, de Oliveira Balen G, dos Santos DB, Budni J, de Freitas AE, et al. Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress. J Psychiatr Res. 2012;46(3):331-40.
  3. Russo AJ. Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes After Zinc and Anti-oxidant Therapy. Nutr Metab Insights. 2010;3:37-42.
  4. Zhao Z, Wang W, Guo H, Zhou D. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behav Brain Res. 2008;194(1):108-13.
  5. Caiaffo V, Oliveira BD, de Sa FB, Evencio Neto J. Anti-inflammatory, antiapoptotic, and antioxidant activity of fluoxetine. Pharmacol Res Perspect. 2016;4(3):e00231.
  6. Aljeboury GH. Anti-Inflammatory effect of Cordia myxa extract on bacteria that Infected wounds in rats as a model for human. Ann Romanian Soc Cell Biol. 2021;13:16040-5.
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