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Ibrahim Salih, A, Mohammed Saleh, H, Sulaiman Khalaf, A, Sabbar Ayed, H. (1401). Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A. سامانه مدیریت نشریات علمی, 77(3), 1083-1089. doi: 10.22092/ari.2022.357266.2005
A Ibrahim Salih; H Mohammed Saleh; A Sulaiman Khalaf; H Sabbar Ayed. "Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A". سامانه مدیریت نشریات علمی, 77, 3, 1401, 1083-1089. doi: 10.22092/ari.2022.357266.2005
Ibrahim Salih, A, Mohammed Saleh, H, Sulaiman Khalaf, A, Sabbar Ayed, H. (1401). 'Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A', سامانه مدیریت نشریات علمی, 77(3), pp. 1083-1089. doi: 10.22092/ari.2022.357266.2005
Ibrahim Salih, A, Mohammed Saleh, H, Sulaiman Khalaf, A, Sabbar Ayed, H. Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A. سامانه مدیریت نشریات علمی, 1401; 77(3): 1083-1089. doi: 10.22092/ari.2022.357266.2005

Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A

Archives of Razi Institute
مقاله 20، دوره 77، شماره 3، مرداد و شهریور 2022، صفحه 1083-1089    اصل مقاله (1.35 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357266.2005
نویسندگان
A Ibrahim Salih* 1؛ H Mohammed Saleh2؛ A Sulaiman Khalaf2؛ H Sabbar Ayed2
1Department of Mechanization and Agricultural Equipment, College of Agriculture, Al-Hawija, University of Kirkuk, Kirkuk, Iraq
2Department of Food Sciences and Biotechnology, College of Agriculture, Tikrit University, Tikrit, Iraq
چکیده
Bisphenol A (BPA) is a synthetic compound with alterations in the liver, antioxidant enzymes, and reproductive hormones. The therapeutic potential of Moringa oleifera extract has recently been considered. The present study aimed to estimate the leaf extract of M. oleifera against hepatotoxicity induced by BPA. In total, 44 adult male rats were used in this study, and the experiment was conducted on 11 groups (4 animals per group). The rats were administrated (orally) with 5 and 10 mg/kg BPA and treated (orally) with 100, 200, 300, and 400 mg/kg of the aqueous extract of M. oleifera. After 28 days of challenge, liver enzymes, including aspartate transaminase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as a pathological study using the liver tissue sections were determined. The findings showed a significant (P≤0.05) increase in the AST, ALT, and ALP in the BPA groups with different histological changes that included the sclerosis of the bile duct surrounded by fibrocytes and lymphocytes infiltration. After treatment with M. oleifera, the liver enzymes and tissue returned to a normal state and showed non-significant (P≤0.05) differences, compared to the control group. According to the results, it can be concluded that the aqueous extract of M. oleifera has a great potential to prevent and improve liver damage of BPA.
کلیدواژه‌ها
Bisphenol A؛ Liver enzymes؛ Moringa oleifera
مراجع
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