| تعداد نشریات | 285 |
| تعداد نشریات سازمان | 83 |
| تعداد شمارهها | 3,094 |
| تعداد مقالات | 34,549 |
| تعداد مشاهده مقاله | 49,442,060 |
| تعداد دریافت فایل اصل مقاله | 79,874,019 |
Enhancement of Productive Performance, Bone Physical Characteristics, and Mineralization of Laying Hens during the Post-Peak Period by Genistein | ||
| Archives of Razi Institute | ||
| مقاله 19، دوره 76، شماره 2، شهریور 2021، صفحه 359-369 اصل مقاله (444.03 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2020.342143.1454 | ||
| نویسندگان | ||
| T Saberifar* 1؛ F Samadi1؛ B Dastar1؛ S Hasani1؛ M Kazemifard2؛ F Ganji3 | ||
| 1Faculty of Animal Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran | ||
| 2Department of Animal Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran | ||
| 3Department of Biology, Faculty of Sciences, Golestan University, Gorgan, Iran | ||
| چکیده | ||
| Genistein (GEN), a soybean isoflavone, is structurally and functionally similar to endogenous estrogen; therefore, it has the potential to enhance estradiol properties. This study aimed to evaluate the effects of GEN on the reproductive performance and bone status of laying hens. In total, 80 Hy-line W-36 (40 weeks old, the late stage of egg production cycle) with an initial body weight of 1,230±15.8 g (Mean±S.E.M), similar egg production, and egg weight were randomly assigned into two groups with 10 replicates and 4 birds in each replicate (40 laying hens per group). Laying hen diets had 0 (control) and 20 mg/kg GEN (white powder, Sichuan Guanghan co. Ltd., purity of 98.5%) for 6 weeks (41 to 46). At the end of the experiment, 20 hens (one hen from each replicate) were slaughtered, and the samples of bone and shell gland (approximately 50 mg) were surgically taken immediately after slaughter for Real-time PCR. The results indicated that dietary GEN increased egg production, feed intake, and egg mass; however, it decreased egg weight (p <0.05). Furthermore, the feed conversion ratio was greater in birds received GEN, compared to those in the control group (p <0.05). GEN enhanced egg quality indices included eggshell strength, thickness, and percentage (p <0.05). Mechanical properties of the tibia, such as weight, length, and breaking strength were also increased by GEN (p <0.05). Moreover, dietary GEN increased the calcium content of the tibia (p <0.05). The mRNA expression of Calbindin-D28k (CaBP-D28k) and transient receptor potential vanilloid channel type 6 (TRPV6) upregulated in eggshell glands of hens treated with GEN paralleled to the controls (p <0.05). In conclusion, the findings of the present study showed that GEN had the potential to improve the bone physical characteristics, mineralization, and the productive performance of Hy-line W-36 laying hens in their post-peak period. | ||
| کلیدواژهها | ||
| Bone؛ CaBP-D28k؛ Genistein؛ Productive performance؛ TRPV6 | ||
| عنوان مقاله [English] | ||
| تاثیر جنستئین بر عملکرد تولیدی و شاخص های مکانیکی استخوان مرغان تخمگذار پس از دوره پیک تولید | ||
| چکیده [English] | ||
| جنیستئین (GEN)، ایزوفلاوون سویا و از نظر ساختاری و عملکردی مشابه استروژن درون زا است. بنابراین، این پتانسیل را دارد که خواص استرادیول را تقویت کند. این پژوهش به منظور بررسی آثار GEN بر عملکرد تولید مثلی و شاخصهای مکانیکی استخوان مرغان تخمگذار پس از دوره پیک تولید طراحی شد. شمار هشتاد قطعه مرغ تخمگذار (WK Hy-line W-36) با وزن اولیه 8/15±1230 گرم به صورت تصادفی به دو گروه (گروه کنترل تغذیه جیره پایه و گروه دوم جیره پایه بعلاوه 20 میلی گرم در کیلوگرم GEN) با 10 تکرار و 4 پرنده در هر تکرار تقسیم شدند و به مدت شش هفته (هفته 41 تا 46) تغذیه شدند. در پایان آزمایش 20 مرغ (یک مرغ از هر تکرار) کشتار و نمونههای استخوان و غده پوسته برای بررسی بیان ژن مورد استفاده قرار گرفتند. نتایج نشان داد که مکمل GEN باعث افزایش تولید تخم مرغ، افزایش مصرف خوراک، افزایش توده تخم مرغ و کاهش وزن تخم مرغ شد (05/0>P). ضریب تبدیل خوراک در پرندگان دریافت کننده GEN نسبت به گروه کنترل بهتر بود (05/0>P). مکمل GEN باعث افزایش شاخصهای کیفیت تخم مرغ از جمله مقاومت پوسته تخم مرغ، ضخامت پوسته تخم مرغ و درصد پوسته تخم مرغ شد (05/0>P). خواص مکانیکی استخوان درشت نی مانند وزن ، طول و استحکام شکست توسط مکمل GEN افزایش یافت (05/0>P). مکمل GENمیزان کلسیم استخوان درشت نی را افزایش داد. (05/0>P). بیان mRNA مربوط به ژنهای پروتئین متصل شونده به کلسیم(CaBP-D28k) و گیرنده گذرا بالقوه کانال وانیلوئید نوع 6 (TRPV6) در غدد پوسته تخم مرغ مرغ-های تغذیه شده با GEN در مقایسه با کنترل افزایش یافت (05/0>P). یافته های پژوهش حاضر نشان داد که مکمل GEN پتانسیل بهبود وضعیت استخوان و عملکرد تولیدی مرغ تخمگذار را در دوره پس از پیک تولید دارد | ||
| کلیدواژهها [English] | ||
| استخوان, جنئستین, عملکرد تولیدمثلی, CaBP-D28k, TRPV6 | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
Akdemir, F., Sahin, K., 2009. Genistein supplementation to the quail: effects on egg production and egg yolk genistein, daidzein, and lipid peroxidation levels. Poult Sci 88, 2125-2131.
Arjmandi, B.H., Alekel, L., Hollis, B.W., Amin, D., Stacewicz-Sapuntzakis, M., Guo, P., et al., 1996. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 126, 161-167.
Arjmandi, B.H., Lucas, E.A., Khalil, D.A., Devareddy, L., Smith, B.J., McDonald, J., et al., 2005. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr J 4, 8.
Bar, A., 2009. Differential Regulation of Calbindin in the Calcium-Transporting Organs of Birds with High Calcium Requirements. J Poult Sci 46, 267-285.
Bar, A., Vax, E., Striem, S., 1992. Relationships between calbindin (Mr 28,000) and calcium transport by the eggshell gland. Comp Biochem Physiol A 101, 845-848.
Bar, A., Vax, E., Striem, S., 1999. Relationships among age, eggshell thickness and vitamin D metabolism and its expression in the laying hen. Comp Biochem Physiol A Mol Integr Physiol 123, 147-154.
Barnes, S., Blair, H.C., 1996. Genistein for use in inhibiting osteoclasts. US patent, pp. 506-211.
Beck, M.M., Hansen, K.K., 2004. Role of estrogen in avian osteoporosis. Poult Sci 83, 200-206.
Blake, G.M., Fogelman, I., 2002. Chapter 91 - Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry. In: Bilezikian, J.P., Raisz, L.G., Rodan, G.A. (Eds.), Principles of Bone Biology (Second Edition), Academic Press, San Diego, pp. 1573-1585.
Cao, J., Echelberger, R., Liu, M., Sluzas, E., McCaffrey, K., Buckley, B., et al., 2015. Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring. Reprod Toxicol 58, 282-294.
Cassidy, A., 2003. Potential risks and benefits of phytoestrogen-rich diets. Int J Vitam Nutr Res 73, 120-126.
de Matos, R., 2008. Calcium metabolism in birds. Vet Clin North Am Exot Anim Pract 11, 59-82, vi.
Dixon, R.A., Ferreira, D., 2002. Genistein. Phytochemistry 60, 205-211.
Fonseca, D., Ward, W.E., 2004. Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice. Bone 35, 489-497.
Gao, Y.H., Yamaguchi, M., 1998. Zinc Enhancement of Genistein’s Anabolic Effect on Bone Components in Elderly Female Rats. Gen Pharmacol-Vasc S 31, 199-202.
Gjorgovska, N., Filev, K., Levkov, V., Nastova, R., Jusufi, E., 2016. Effects of dietary supplementatwith isoflavones on exterior development and tibia bone quality of laying hens. Slovak J of Anim Sci 3, 112-115.
Hosseini, S., Kermanshahi, H., Nassirimoghaddam, H., Nabipour, A., Mirakzeh, M., Saleh, H., et al., 2016. Effects of 1.25-Dihydroxycholecalciferol and Hydroalcoholic Extract of Withania Coagulans Fruit on Bone Mineralization and Mechanical and Histological Properties of Male Broiler Chickens. Braz J Poultry Sci 18, 73-86.
Jiang, Z.Y., Jiang, S.Q., Lin, Y.C., Xi, P.B., Yu, D.Q., Wu, T.X., 2007. Effects of soybean isoflavone on growth performance, meat quality, and antioxidation in male broilers. Poult Sci 86, 1356-1362.
Jonchere, V., Brionne, A., Gautron, J., Nys, Y., 2012. Identification of uterine ion transporters for mineralisation precursors of the avian eggshell. BMC Physiol 12, 10.
Kajiya, H., Okabe, K., Okamoto, F., Tsuzuki, T., Soeda, H., 2000. Protein tyrosine kinase inhibitors increase cytosolic calcium and inhibit actin organization as resorbing activity in rat osteoclasts. J Cell Physiol 183, 83-90.
Liu, H.Y., Zhang, C.Q., 2008. Effects of daidzein on messenger ribonucleic Acid expression of gonadotropin receptors in chicken ovarian follicles. Poult Sci 87, 541-545.
Lv, Z.P., Yan, S.J., Li, G., Liu, D., Guo, Y.M., 2019. Genistein improves the reproductive performance and bone status of breeder hens during the late egg-laying period. Poult Sci 98, 7022-7029.
Molnár, L., 2010. Fracture repair technics in birds. Diseases of birds, exotic and free living animals, Budapest: Mavak.
Ni, Y., Zhu, Q., Zhou, Z., Grossmann, R., Chen, J., Zhao, R., 2007. Effect of dietary daidzein on egg production, shell quality, and gene expression of ER-alpha, GH-R, and IGF-IR in shell glands of laying hens. J Agric Food Chem 55, 6997-7001.
Orban, J.I., Adeola, O., Stroshine, R., 1999. Microbial phytase in finisher diets of White Pekin ducks: effects on growth performance, plasma phosphorus concentration, and leg bone characteristics. Poult Sci 78, 366-377.
Patel, S., Peretz, J., Pan, Y.X., Helferich, W.G., Flaws, J.A., 2016. Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles. Toxicol Appl Pharmacol 293, 53-62.
Price, K.R., Fenwick, G.R., 1985. Naturally occurring oestrogens in foods--a review. Food Addit Contam 2, 73-106.
Rath, N.C., Balog, J.M., Huff, W.E., Huff, G.R., Kulkarni, G.B., Tierce, J.F., 1999. Comparative differences in the composition and biomechanical properties of tibiae of seven- and seventy-two-week-old male and female broiler breeder chickens. Poult Sci 78, 1232-1239.
Reichmann, K.G., Connor, J.K., 1977. Influence of dietary calcium and phosphorus on metabolism and production in laying hens. Br Poult Sci 18, 633-640.
Retana-Marquez, S., Juarez-Rojas, L., Hernandez, A., Romero, C., Lopez, G., Miranda, L., et al., 2016. Comparison of the effects of mesquite pod and Leucaena extracts with phytoestrogens on the reproductive physiology and sexual behavior in the male rat. Physiol Behav 164, 1-10.
Sahin, N., Onderci, M., Balci, T.A., Cikim, G., Sahin, K., Kucuk, O., 2007. The effect of soy isoflavones on egg quality and bone mineralisation during the late laying period of quail. Br Poult Sci 48, 363-369.
Saitoh, S., Sato, T., Harada, H., Takita, T., 2001. Transfer of soy isoflavone into the egg yolk of chickens. Biosci Biotechnol Biochem 65, 2220-2225.
Shin, J.-H., Park, J., Kim, J.-M., Roh, K.-S., Jung, W.-S., 2012. The Improvement of Laying Productivity and Egg Quality according to Providing Germinated and Fermented Soybean for a Feed Additive. Korean J Food Sci Anim Resour 32, 404-408.
Steinshamn, H., 2010. Effect of forage legumes on feed intake, milk production and milk quality - a review. Anim Sci Pap Rep 28, 195-206.
Sugiyama, T., Kikuchi, H., Hiyama, S., Nishizawa, K., Kusuhara, S., 2007. Expression and localisation of calbindin D28k in all intestinal segments of the laying hen. Br Poult Sci 48, 233-238.
Taylor, A.N., Wasserman, R.H., 1967. Vitamin D3-induced calcium-binding protein: Partial purification, electrophoretic visualization, and tissue distribution. Arch Biochem Biophys 119, 536-540.
Yang, H., Choi, K.C., Hyun, S.H., Jeung, E.B., 2011. Coexpression and estrogen-mediated regulation of TRPV6 and PMCA1 in the human endometrium during the menstrual cycle. Mol Reprod Dev 78, 274-282.
Yang, J.-H., Hou, J.-F., Deng, Y.-F., Zhou, Z.-L., Wang, Y.-M., Shi, L.-J., 2012. Expression of TRPV6 in Different Reproductive Organs in Laying Hens. Agri Sci Technol 45, 184-191.
Yang, J.H., Zhao, Z.H., Hou, J.F., Zhou, Z.L., Deng, Y.F., Dai, J.J., 2013. Expression of TRPV6 and CaBP-D28k in the egg shell gland (uterus) during the oviposition cycle of the laying hen. Br Poult Sci 54, 398-406.
Yosefi, S., Braw-Tal, R., Bar, A., 2003. Intestinal and eggshell calbindin, and bone ash of laying hens as influenced by age and molting. Comp Biochem Physiol A Mol Integr Physiol 136, 673-682.
Zhao, R.Q., Zhou, Y.C., Ni, Y.D., Lu, L.Z., Tao, Z.R., Chen, W.H., et al., 2005. Effect of daidzein on egg-laying performance in Shaoxing duck breeders during different stages of the egg production cycle. Br Poult Sci 46, 175-181.
Zhao, Y., Liu, W., Zeng, J., Liu, S., Tan, X., Aljohi, H., et al., 2016. Identification and analysis of mouse non-coding RNA using transcriptome data. Sci China Life Sci 59, 589-603. | ||
|
آمار تعداد مشاهده مقاله: 2,143 تعداد دریافت فایل اصل مقاله: 2,816 |
||
