Estimation of genomic inbreeding coefficient and effective population size in Zandi sheep breed using density SNP markers (50K SNPChip) | ||
| علوم دامی | ||
| Article 12, Volume 31, Issue 119, September 2018, Pages 129-142 PDF (1.93 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.22092/asj.2017.115308.1527 | ||
| Authors | ||
| Hosein Mohammadi1; abbas rafat* 2; Hossein Moradi Shahrebabak3; Jalil Shodja4; Mohammad Hossein Moradi5 | ||
| 1Department of animal science, University of Tabriz | ||
| 2animal science- university of Tabriz | ||
| 3Department of Animal Sciences, University College of Agriculture and Natural Resources, University of Tehran. | ||
| 4Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz | ||
| 5Department of Animal Sciences, Faculty of Agriculture and Natural Resources, University of Arak | ||
| Abstract | ||
| The aim of this study was to investigate genome-wide Inbreeding and effective population size using the information obtained from 96 Zandi sheep breed using a density SNP panel (50K SNPChip). For this purpose, after quality control of SNP markers data, 40,879 SNPs were remained for computing inbreeding and effective population size. Effective number of breeders was estimated per each chromosome using NEESTIMATOR software based on heterozygote-excess method., and inbreeding coefficient was derived using four methods including, genomic relationship matrix (FGRM), excess of homozygosity (FHOM), correlation between uniting gametes (FUNI) using GCTA software and run of homozygosity (FROH) using PLINK software. Average expected and observed heterozygosity ranged 0.393 and 0.407 respectively. Average chromosome-wise effective number of breeders was equal to 69 and corresponding average confidence interval was between 40.0 and 93.26. The magnitude of inbreeding coefficient using FGRM, FHOM, and FUNI was similar (0.064) and it was estimated 0.053 using Run of homozygosity. Generally, the results indicated that although a considerable genetic variation exists in Zandi population in case study, however effective population has been decreased strongly in Zandi sheep breed during recent years and designing of appropriate programs is necessary to conserve remaining purebred animals of this indigenous sheep breed. | ||
| Keywords | ||
| Sheep; Genomic Inbreeding; Effective population size; Single Nucleotide Polymorphism | ||
| References | ||
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