Shojaei, M., Selk ghaffari, M., Marjani, M. (2018). Effect of Propofol infusion on serum concentrations of glucose, cholesterol, triglyceride and related arrhythmia in dogs. , 31(3), 44-49. doi: 10.22092/vj.2018.120604.1434
M. Shojaei; M. Selk ghaffari; M. Marjani. "Effect of Propofol infusion on serum concentrations of glucose, cholesterol, triglyceride and related arrhythmia in dogs". , 31, 3, 2018, 44-49. doi: 10.22092/vj.2018.120604.1434
Shojaei, M., Selk ghaffari, M., Marjani, M. (2018). 'Effect of Propofol infusion on serum concentrations of glucose, cholesterol, triglyceride and related arrhythmia in dogs', , 31(3), pp. 44-49. doi: 10.22092/vj.2018.120604.1434
Shojaei, M., Selk ghaffari, M., Marjani, M. Effect of Propofol infusion on serum concentrations of glucose, cholesterol, triglyceride and related arrhythmia in dogs. , 2018; 31(3): 44-49. doi: 10.22092/vj.2018.120604.1434

Effect of Propofol infusion on serum concentrations of glucose, cholesterol, triglyceride and related arrhythmia in dogs

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Article 6, Volume 31, Issue 3 - Serial Number 120, August 2018, Pages 44-49    PDF (472 K)
Document Type: Full Research Paper
DOI: 10.22092/vj.2018.120604.1434
Authors
M. Shojaei* 1; M. Selk ghaffari2; M. Marjani2
1موسسه تحقیقات Razi Vaccine and Serum Research institute, Agricultural Research, Education and Extension organization (AREEO), Karaj, Iran. واکسن و سرم سازی رازی
2Department of Clinical Sciences, School of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran.
Abstract
Propofol is an alkylphenol that belongs to the non-barbiturates anaesthesia drugs. Because of its appropriate pharmacodynamics and pharmacokinetic characteristics, Propofol can be administrated as total intravenous anesthesia (TIVA). This study was aimed to determine effect of total intravenous anaesthesia by Propofol on serum concentrations of glucose, cholesterol, and triglyceride, and also its influence on electrocardiograph parameters in dogs. A total of 10 adult cross-breed (including 5 male and 5 female) dogs were randomly selected and pre-anesthetized by intravenous diazepam (0.5mg/kg). After 10 min, animals were anesthetized with 5 mg/kg Propofol, and anaesthesia was maintained with a constant infusion of 0.5 mg/kg/min Propofol for one hour. Before and at 30 and 60 minutes following induction of anaesthesia, serum concentrations of glucose, cholesterol, and triglyceride were measured, and electro cardio graph (EKG) strip was taken. Propofol had no significant effect on serum cholesterol and glucose concentrations. Serum concentrations of triglyceride were increased at 30 (P < 0.001) and 60 (P = 0.001) minutes following induction of anaesthesia. In addition, a significant decrease in hart rate was observed in EKG parameters at 30 and 60 minutes following anaesthesia induction. In conclusion, our results showed appropriate characteristics of Propofol to use TIVA anaesthesia. Moreover, Propofol may have some effects on serum lipid profiles and also causes bradycardia in dogs.
Keywords
Propofol; Glucose; Triglyceride; Cholesterol; arrhythmia
References

1-Carrasco, G., Molina, R., Costa, J., Soler, J.-M., Cabré, L., 1993. Propofol vs Midazolam in Short-, Medium-, and Long-term Sedation of Critically III Patients: A Cost-Benefit Analysis. Chest 103, 557-564.
2-Clarke, K.W., Trim, C.M., 2013. Veterinary Anaesthesia E-Book, Elsevier Health Sciences Amesterdam.
3-Crispin, S., 1993. Ocular manifestations of hyperlipoproteinaemia. Journal of small animal practice 34, 500-506.
4- Devaud.J.C, Berger.MM, Pannatier. A, Marques-Vidal. P, Tappy. L, Rodondi. N, Chiolero.R, Voirol. P, 2012. Hypertriglyceridemia: a potential side effect of propofol sedation in critical illness, Intensive Care Med 38,1990-1998
5-Devlin, J.W., Lau, A.K., Tanios, M.A., 2005. Propofol‐associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 25, 1348-1352.
6-Fadaeizadeh, L., Radpey, B., Mohammad, T.Z., Bou, A.A., Shahsavari, F., Mousavi, F., 2007. Comparison of propofol and remifentanil administration on lipid profile Tanaffos, 6,31-36.
7-Ford, R., 1993. Idiopathic hyperchylomicronaemia in miniature schnauzers. Journal of Small Animal Practice 34, 488-492.
8-Gottschling, S., Meyer, S., Krenn, T., Kleinschmidt, S., Reinhard, H., Graf, N., et al., 2005. Effects of short‐term propofol administration on pancreatic enzymes and triglyceride levels in children. Anaesthesia 60, 660-663.
9-Grimm, K.A., Lamont, L.A., Tranquilli, W.J., Greene, S.A., Robertson, S.A., 2015. Veterinary anesthesia and analgesia: the fifth edition of Lumb and Jones, John Wiley & Sons USA.
10-Kimura, T., Hasegawa, M., 2001. Effect of intra-operative propofol administration on post-operative serum lipid concentrations. Masui. The japanese journal of anesthesiology 50, 100-101
11-Kruse-Elliott, K.T., 2008. Induction agents and total intravenous anesthesia. small animal anesthesia and analgesia, edited by Carroll GL. Ames: Blackwell Publishing, 83-94.
12-PE Marik,2004. Propofol:therapeutic indication and side-effects, Current pharmaceutical design,10,3639-3649
13-Mohamadnia, A., Shahbazkia, H., Akhlaghi, M., Shahrokhi, M., Saberin, L., 2008. Clinical evaluation of repeated propofol total intravenous anesthesia in dog. Pakistan Journal of Biological Sciences 11, 1820-1824.
14-Öztekin, I., Gocdogan, S., Öztekin, D.S., Issever, H., Goksel, O., Canik, S., 2007. Effects of propofol and midazolam on lipids, glucose, and plasma osmolality during and in the early postoperative period following coronary artery bypass graft surgery: a randomized trial. Yakugaku Zasshi 127, 173-182.
15-Pereira, G.G., Larsson, M.H., Yamaki, F.L., Soares, E.C., Yamato, R.J., Neto, M.L., et al., 2004. Effects of propofol on the electrocardiogram and systolic blood pressure of healthy cats pre‐medicated with acepromazine. Veterinary anaesthesia and analgesia 31, 235-238.
16-Perumal, N., Ramasamy, V., Kumar, M.M., Majumdar, S.S., 2007. Effects of ketamine and thiopentone anesthesia on serum lipid parameters in adult bonnet monkeys (Macaca radiata). Journal of the American Association for Laboratory Animal Science 46, 21-23.
17-Robinson, B., Buyck, H., Galletly, D., 1994. Effect of propofol on heart rate, arterial pressure and digital plethysmograph variability. British journal of anaesthesia 73, 167-173.
18-Robinson, J.D., Melman, Y., Walsh, E.P., 2008. Cardiac conduction disturbances and ventricular tachycardia after prolonged propofol infusion in an infant. Pacing and clinical electrophysiology 31, 1070-1073.
19-Weaver B.M.Q, Raptopoulos D.1996, Plasma triglyceride concentration during intravenous infusion of propofol and intralipid in sheep. Veterinary Anaesthesia and Analgesia. 23:15-19
20-Yamakage, M., Iwasaki, S., Jeong, S., Ishiyama, S., Namiki, A., 2005. Comparative study between propofol in a long-chain triglyceride and propofol in a medium/long-chain triglyceride during sedation with target-controlled infusion. Anaesthesia and intensive care 33, 351.

 

Statistics
Article View: 654
PDF Download: 358


counter
Journal management system. designed by sinaweb