Khani, S., Sarvi Moghanlou, K., Imani, A., Agh, N., Razi, M. (2017). Capability of dietary supplementation of composite toxin binder in reducing aflatoxin B1 toxicity and its immunomodulation in rainbow trout (Oncorhynchus mykiss) fingerlings. , 30(1), 173-182. doi: 10.22034/vj.2017.107810
Sairan Khani; Kourosh Sarvi Moghanlou; Ahmad Imani; Naser Agh; Mazdak Razi. "Capability of dietary supplementation of composite toxin binder in reducing aflatoxin B1 toxicity and its immunomodulation in rainbow trout (Oncorhynchus mykiss) fingerlings". , 30, 1, 2017, 173-182. doi: 10.22034/vj.2017.107810
Khani, S., Sarvi Moghanlou, K., Imani, A., Agh, N., Razi, M. (2017). 'Capability of dietary supplementation of composite toxin binder in reducing aflatoxin B1 toxicity and its immunomodulation in rainbow trout (Oncorhynchus mykiss) fingerlings', , 30(1), pp. 173-182. doi: 10.22034/vj.2017.107810
Khani, S., Sarvi Moghanlou, K., Imani, A., Agh, N., Razi, M. Capability of dietary supplementation of composite toxin binder in reducing aflatoxin B1 toxicity and its immunomodulation in rainbow trout (Oncorhynchus mykiss) fingerlings. , 2017; 30(1): 173-182. doi: 10.22034/vj.2017.107810

Capability of dietary supplementation of composite toxin binder in reducing aflatoxin B1 toxicity and its immunomodulation in rainbow trout (Oncorhynchus mykiss) fingerlings

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Article 21, Volume 30, Issue 1, March 2017, Pages 173-182    PDF (1.71 M)
Document Type: Full Research Paper
DOI: 10.22034/vj.2017.107810
Authors
Sairan Khani1; Kourosh Sarvi Moghanlou* 2; Ahmad Imani2; Naser Agh3; Mazdak Razi4
1MSc Graduate of Fisheries Science, Department of Fisheries, Faculty of Natural Resources, Urmia University, I.R. of Iran.
2Assistant Professor, Department of Fisheries, Faculty of Natural Resources, Urmia University, I.R. of Iran.
3Associate Professor, Urmia Lake Research Institute, Urmia University, I.R. of Iran.
4Assistant Professor, Department of Comparative Histology and Embryology, Faculty of Veterinary Medicine, Urmia University, I.R. of Iran.
Abstract
In the present study, the effects of aflatoxin B1 (AFB1) and a compound binder on blood cell count, biochemical indices of serum and liver histology of rainbow trout was investigated. In this regard, total number of 414 trout fingerlings (9.67±1.20g) were randomly allocated into six different treatments comprising various dietary inclusion levels of AFB1 (0, 25 and 50 ppb) and binder (0 and 5%) for 60 days. At the end of experiment, blood indices did not differ amongst treatments. The highest and lowest levels of ALP activities were observed in treatments fed diets containing 5% binder-25 ppb AFB1 and the group without any dietary aflatoxin and binder inclusions, respectively (P<0.05). Activities of AST and ALT were only affected by the binder to the extent that its presence led to lower enzymes activity (P<0.05). Interaction of AFB1 and binder significantly affected total protein and globulin content (P<0.05). The albumin content was only affected by the binder (P<0.05). According to the results AFB1 reduced HSI (P<0.05). Blood vessels dilation, cytoplasmic degeneration, blood congestion and hepatic immune cells infiltration were observed in fish fed aflatoxin-contaminated diets which were severe in 50 ppb AFB1-recieved groups. In conclusion, The AFB1 resulted in liver tissue damage and despite improving the immune indices; binder did not show remarkable hepato-protective effects.
Keywords
Aflatoxin B1; Bentonite; Prebiotic; Rainbow trout
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