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Seroprevalence, symptom associations, and biomarker dynamics of Helicobacter pylori in dyspeptic patients from Kerman, Iran: A focus on CagA status | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 23 آبان 1405 اصل مقاله (692.62 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.66224/ari.2026.371779.3995 | ||
| نویسندگان | ||
| Sadegh Afzali1؛ Mojtaba Alimolaei* 2؛ Faranak Saeidnia3؛ Shirin Soltani4؛ Sadegh Khorrami5 | ||
| 1Department of Toxicology and Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran | ||
| 2Department of Molecular Microbiology, Kerman branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran | ||
| 3Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Guilan province, Iran | ||
| 4Research and Development Department, Kerman branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran. | ||
| 5Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran | ||
| چکیده | ||
| Introduction: Infection with Helicobacter pylori, especially strains positive for the cytotoxin-associated gene A (CagA), is a well-recognized etiological factor in the carcinogenesis of gastric cancer; however, its relationship with serum cancer biomarker levels in non-cancerous individuals remains unclear. Objective: This research was intended to assess the relationship between the status of H. pylori infection, CagA seropositivity, and levels of cancer antigens (CEA, CA19-9, and CA125) in dyspeptic patients without cancer diagnosis. Material and Methods: We randomly selected 91 participants with digestive symptoms (70 H. pylori IgG-positive and 21 IgG-negative) and determined their CagA status using ELISA. Then, 50 CagA-positive and 10 CagA-negative patients were selected for the cancer biomarker sub-analysis using the electrochemiluminescence immunoassay. Results: H. pylori IgG positivity and higher quantitative IgG titers were strongly associated with stomach pain, bloating, and belching (p<0.001). Anti‑CagA IgG correlated significantly with stomach pain, belching, prior endoscopy, and a history of gastric ulcer. We did not observe significant differences in mean levels of CEA (p = 0.25), CA19-9 (p = 0.90), or CA125 (p = 0.15) between CagA-positive and CagA-negative groups. Gender showed no significant association with biomarker levels, while age demonstrated a significant correlation with CEA levels (p=0.003); younger patients exhibited higher rates of abnormal CEA levels. Conclusion: This study showed no significant association between H. pylori infection and CagA status and increased levels of cancer biomarkers in dyspeptic patients without a history of cancer. These results enhance the understanding of the complex relationship between H. pylori infection and cancer biomarker expression. | ||
| کلیدواژه‌ها | ||
| Helicobacter pylori؛ CagA seropositivity؛ Dyspepsia؛ Cancer biomarkers؛ IgG-positive | ||
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