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Shanmugaraj, Balamurugan, Nagaraj, Ajith, Saravanan, Pavaroseni, Balasubramaniyan, Thamizharasan. (1405). Potential of Plant Expression System for the Production of Vaccines and Biologics Against Bundibugyo Ebolavirus. سامانه مدیریت نشریات علمی, (), -. doi: 10.66224/ari.2026.373459.4214
Balamurugan Shanmugaraj; Ajith Nagaraj; Pavaroseni Saravanan; Thamizharasan Balasubramaniyan. "Potential of Plant Expression System for the Production of Vaccines and Biologics Against Bundibugyo Ebolavirus". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.66224/ari.2026.373459.4214
Shanmugaraj, Balamurugan, Nagaraj, Ajith, Saravanan, Pavaroseni, Balasubramaniyan, Thamizharasan. (1405). 'Potential of Plant Expression System for the Production of Vaccines and Biologics Against Bundibugyo Ebolavirus', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.66224/ari.2026.373459.4214
Shanmugaraj, Balamurugan, Nagaraj, Ajith, Saravanan, Pavaroseni, Balasubramaniyan, Thamizharasan. Potential of Plant Expression System for the Production of Vaccines and Biologics Against Bundibugyo Ebolavirus. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.66224/ari.2026.373459.4214

Potential of Plant Expression System for the Production of Vaccines and Biologics Against Bundibugyo Ebolavirus

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 23 آبان 1405    اصل مقاله (757.65 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.66224/ari.2026.373459.4214
نویسندگان
Balamurugan Shanmugaraj* 1؛ Ajith Nagaraj2؛ Pavaroseni Saravanan2؛ Thamizharasan Balasubramaniyan2
1Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, 641021, Tamil Nadu, India
2Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, 641021, Tamil Nadu, India
چکیده
The recent outbreak of Bundibugyo ebolavirus (BDBV) in Africa received global attention due to its ability to cause severe hemorrhagic disease with high mortality rates. This virus belongs to the family Filoviridae and genus Orthoebolavirus. It is one of the ebolavirus species known to infect humans. World Health Organization (WHO) has declared the current outbreak in Democratic Republic of Congo as Public health emergency of international concern on May 2026. Although there is significant progress in vaccine and therapeutic development against Zaire ebolavirus, there are no approved vaccines or therapeutics currently available for BDBV. The vaccine development efforts using different platform technologies are currently in progress. Recently, plant expression systems have emerged as a promising platform for the rapid, scalable, and cost-effective production of recombinant vaccines and biopharmaceuticals. Furthermore, the production of Ebola virus antigens and the monoclonal antibody cocktail ZMapp in Nicotiana benthamiana provides proof-of-concept that the plant expression platform can be utilized for the development of filovirus countermeasures. Here we examine the potential of plant expression systems for the development of vaccines and biologics against BDBV.
کلیدواژه‌ها
Bundibugyo ebolavirus؛ molecular farming؛ outbreak preparedness؛ plant expression systems؛ recombinant vaccines
آمار
تعداد مشاهده مقاله: 3
تعداد دریافت فایل اصل مقاله: 2


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