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Activated monoaminergic pathway in laying hen spleen after two vaccinations against H5N1 virus vaccine: based on microarray data | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 20 آبان 1405 اصل مقاله (1.11 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.66224/ari.2026.371426.3948 | ||
| نویسندگان | ||
| Yadollah Badakhshan* ؛ Arsalan Barazandeh؛ Mozhgan Mazhari | ||
| Department of Animal Science, Faculty of Agriculture, University of Jiroft, Jiroft, Iran. | ||
| چکیده | ||
| Monoamines regulate the activity of the immune system during infection. Monoamines can induce a response in immune cells through their receptors. Spleen is the main immune organ in poultry to achieve immunity during vaccination. monoaminergic system after vaccination will provide significant information. While there is substantial research into avian influenza , for strains like H5N1, there is no direct information regarding vaccination against an H5N1 virus impact on the serotonergic system. Geo data of splenic microarray (accession number GSE135671 and GSE102972) used in this research. Five hundred White Leghorn chicks were split into a control group with no vaccine and a group vaccinated twice 14 days apart. Layer chicken’s spleens were collected 7 days after 2th vaccination. Researchers investigated gene expression in the spleens of chickens following their second dose of the H5N1 vaccine. The study found that 637 genes showed different levels of expression when comparing spleen of vaccinated chickens to those in the control group. Splenic gene expression increased significantly about HTR2A, HTR1B, MTNR1B genes of serotonergic pathway compared to control chickens (P<0.001). vaccination significantly elevated MirRNAs gene expression MIR101-2, MIR193B, MIR302C, MIR1815, MIR1575 and MIR1664 related to HTR2A gene (P<0.001). this showed continued activity in serotonergic system of spleen after booster vaccination against pathogenic H5N1 avian influenza virus and this activity was extensively visualized about HTR2A receptor and related MirRNAs. serotonergic system of spleen during vaccination led to a better immunity. miRNAs and their target gene HTR2A work as biomarkers for evaluating immune in poultry after vaccination. | ||
| کلیدواژه‌ها | ||
| spleen؛ layer؛ immunity؛ serotonin؛ poultry influenza | ||
| عنوان مقاله [English] | ||
| فعالیت ژنهای مسیر مونوآمینرژیک طحال مرغ تخم گذار پس از تزریق واکسن ویروس H5N1 | ||
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