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Biophysical Properties, Antimicrobial Activity, and In Vitro Fibroblast Migration of Propolis-Loaded Electrospun Polycaprolactone Fibers | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 آبان 1405 اصل مقاله (3.45 M) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2027.373916.2254 | ||
| نویسندگان | ||
| Vahid Safavizadeh1؛ fatemeh Fatemeh Sadeghian-Nodoushan2، 3؛ Ali Akbar Karimi Zarchi3؛ Sara Naji Tabasi4؛ Mohammadreza Rostami5؛ Hossein Naderi-Manesh* 1 | ||
| 1Department of Biophysics, Faculty of Biological Science, Tarbiat Modares University, 14115-154, Tehran, Iran | ||
| 2Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 3School of Advanced Medical Technologies, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 4Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran | ||
| 5Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| چکیده | ||
| Propolis, a resinous substance produced by honeybees, possesses potent antioxidant, antimicrobial, and regenerative properties, making it a promising bioactive agent for wound healing. Electrospun Polycaprolactone fibers containing 10% Propolis were prepared using a chloroform–methanol solvent system and compared with Propolis-free control fibers. The samples were characterized for morphology, thermal and mechanical properties, wettability, antimicrobial activity, in vitro wound healing using a fibroblast scratch assay, and molecular docking of pinobanksin with wound-healing-related proteins, followed by statistical analysis using an independent samples t-test. SEM images revealed a uniform fiber network with reduced pore size in Propolis-loaded samples, while WDX confirmed the loading of Propolis extract into the fibers. Propolis slightly increased the melting temperature from 61.6 °C to 63.8 °C. The water contact angle decreased from 113.2° to 64.4°, indicating increased surface wettability and decreased tensile strength from 1.98 MPa to 0.86 MPa. The fibers showed strong antibacterial activity against E. coli and Staphylococcus aureus with 99.5% reduction, antifungal activity against Mucor racemosus with 70% reduction, enhanced fibroblast migration with 84.97% wound closure, and strong pinobanksin binding to wound-related proteins such as 966C (−10.1 kcal/mol) and 4XCT (−9.5 kcal/mol). These results indicate that electrospun fibers containing Propolis can contribute to the development of wound dressings. However, in the scratch assay, electrospun fibers containing Propolis did not perform better than the control sample, a finding that warrants further investigation. | ||
| کلیدواژه‌ها | ||
| Propolis؛ Electrospinning؛ Polycaprolactone؛ Fibroblast Migration؛ Wound Healing؛ Antimicrobial Activity | ||
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