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Protective Effects of Coriandrum sativum L. Aerial Parts and Seed Extracts Against Aluminum-Induced Hepatic and Biochemical Alterations in Rats: GC-MS Profiling and Antioxidant Evaluation | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 28 مهر 1405 اصل مقاله (1.86 M) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2026.372149.2139 | ||
| نویسندگان | ||
| Sarvenaz Bigham Soostani1؛ Monireh Ranjbar* 2؛ Msahsa Najafi2 | ||
| 1Hormozgan University, Faculty of Marine Science and Technology, Hormozgan, Iran | ||
| 2Department of Biology, Fal.C., Islamic Azad University, Isfahan, Iran | ||
| چکیده | ||
| Aluminum exposure is linked to oxidative stress and liver damage, primarily due to the excessive formation of reactive oxygen species. Accordingly, this study investigated the hepatoprotective and antioxidant effects of methanolic and ethanolic extracts, which were prepared from both the aerial parts and seeds of Coriandrum sativum L. in Wistar rats with aluminum-induced hepatotoxicity. The animals were randomly assigned to different experimental groups and received the treatments for 30 days. We evaluated the liver function indicators, lipid profile changes, antioxidant enzyme activities, DPPH radical scavenging ability, and also the expression levels of antioxidant-related genes like CAT, GPX1, and SOD2, within the same experimental protocol. Then, GC-MS analysis revealed several bioactive phytochemicals with reported antioxidant potential. After aluminum administration, the liver enzyme levels increased significantly, and the oxidative stress markers were significantly elevated, while antioxidant gene expression decreased significantly. Treatment with Coriandrum sativum L. extracts improved the biochemical and antioxidant parameters significantly compared to the aluminum-treated group (P<0.05), particularly in the methanolic seed extracts. These results suggest that Coriandrum sativum L. has antioxidant and hepatoprotective properties, which may help attenuate aluminum induced liver injury. | ||
| کلیدواژه‌ها | ||
| Coriandrum sativum؛ Hepatoprotection؛ Aluminum toxicity؛ Bioactive Compounds؛ Medicinal Plants | ||
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