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Intensification of the antiviral activity of essential oils against parainfluenza virus PI3 using nanoencapsulation technology | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 مهر 1405 اصل مقاله (1.58 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.66224/ari.2026.373454.4208 | ||
| نویسندگان | ||
| Maedeh Samianifard1؛ Mohsen Lotfi2؛ Hasan Rafati* 1 | ||
| 1Department of Phytochemistry and Department of Pharmaceutical Engineering, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran. | ||
| 2Department of Quality Control, Razi Vaccine and Serum Research, Education and Extension Organization (AREEO), Karaj, Iran. | ||
| چکیده | ||
| Introduction: Enveloped viruses, including Influenza and Coronaviruses, have been considered a major source of life-threatening infections all over the world. Nanotechnology, in conjunction with natural compounds, can provide broad-spectrum virucidal and antiviral formulations to combat these potential threats. Objectives: In this work, nanoemulsions prepared from 8 different essential oils (EOs) with mean particle sizes of 80-200 nm have been screened for the antiviral activities of EOs against Bovine Parainfluenza Virus type 3 (BPI3). Methods: Using high energy homogenization, nanoemulsions were prepared by combining essential oils, surfactants as a colloidal dispersion in water. After primary screening of the antiviral activities, two nanoemulsion formulations of Satureja Khuzistanica (SK NE) and Thymus daenensis (TD NE) were selected for further investigations. Quantitative PCR methods were also utilized to determine the concentration of RNA virus via the virus following TD NE formulation contacts. Results: After 15 minutes of SK NE and TD NE treatments, they showed the lowest cytotoxicity while lowering virus count by more than 5 logarithms. The best nanoemulsion, TD NE formulation, at doses of 20 mg and 10 mg, reduced the virus titer by 4 logs over 2 and 10 minutes, respectively. The best Ct result was observed in pretreatment (36.81±2.38) and then in co-treatment with the formulation (29.50±2.01) compared to the negative control (40.00±1.02). The membrane damage of the BPI3 virus as an enveloped virus was confirmed by TEM images using TD NE formulation. Conclusion: These findings highlight the potential antiviral activity of essential oils in nanoemulsions to disrupt viral envelops. | ||
| کلیدواژه‌ها | ||
| Bovine parainfluenza (BPI3) Virus؛ Nanoemulsions؛ Antiviral activity؛ Essential oil؛ Enveloped viruses | ||
| عنوان مقاله [English] | ||
| تشدید اثردهی فعالیت ضدویروس اسانس ها بر علیه ویروس پاراآنفلوانزا PI3 با کاربرد تکنولوژی نانوانکپسولاسیون | ||
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