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Detection of antibiotic resistance genes in Staphylococcus aureus bacteria isolated from arthritis in broiler chickens, Aleppo countryside, Syria | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 مهر 1405 اصل مقاله (959.17 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.66224/ari.2026.373070.4160 | ||
| نویسندگان | ||
| Abdulkarim HALLAK1؛ Morshed KASSOUHA2؛ Maher SALEH1؛ ASEEM ALBAKER* 3؛ Ammar HAJİ AL ALİ1 | ||
| 1Department of Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Hama University, Hama, Syria | ||
| 2Department of Microbiology, Faculty of Veterinary Medicine, Hama University, Hama, Syria | ||
| 31Department of Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Hama University, Hama, Syria | ||
| چکیده | ||
| Introduction: The danger of Staphylococcus aureus as a leading human and animal pathogen lies in its antimicrobial resistance, which renders standard antibiotics ineffective and severely restricts treatment possibilities. Material and Methods: This study was conducted in the period between January 2026 and February 2026, as samples were collected from 55 farms suffering from cases of lameness in chickens. S. aureus bacteria were isolated using selective media, then antibiotic susceptibility testing was performed, and some antibiotic resistance genes were detected using PCR technique, including mecA, aphD, tet-K, tet-M, erm-C and vat B. Results: According to the results, pathogenic S. aureus accounted for 45.45% of the examined broiler joint lesion cases. The results also showed that all S. aureus isolates belonged to the multidrug-resistant (MDR) category, as they were highly resistant to penicillin G at 100%, followed by streptomycin at 96%, while the highest sensitivity rate was to tilmicosin at 64%, followed by oxacillin at 56%. The methicillin resistance gene mecA was detected in 24% of isolates, the aminoglycoside resistance gene was found in 100% of isolates, 80% of isolates carried the tetracycline resistance gene tet-K, while the tetracycline resistance gene tet-M was found in 48% of isolates, whereas the macrolide resistance gene erm-C was detected in 72% of isolates, and the streptogramin resistance gene vat B was not detected in any of the studied isolates. Conclusion: We conclude from this study antibiotic-resistant S. aureus bacteria, which portends the transmission of this resistance to other bacteria that infect humans, threatening public health. | ||
| کلیدواژه‌ها | ||
| antibiotics؛ arthritis؛ broilers؛ lameness؛ resistance genes؛ Staphylococcus aureus | ||
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