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Formulation and Characterization of an Herbal-Based Topical Organogel | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 مهر 1405 اصل مقاله (993.25 K) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2027.373585.2236 | ||
| نویسندگان | ||
| Maryam Alaayedi* 1، 2؛ Ashti M.H. Saeed3؛ Qasim Allawi Bader4؛ Zahraa M. Kadhum2؛ Ihab Dahham Hammoodi5؛ Mustafa Ghazi Alabbassi6، 7؛ Hasanin Shakir Mahmmod2، 8، 7 | ||
| 1Department of Pharmaceutics, College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq | ||
| 2Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq | ||
| 3Department of Pharmaceutics, College of Pharmacy, AlMustansiriyiah University, Baghdad, Iraq | ||
| 4Assistant professor in pharmaceutics, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq | ||
| 5Al-Esraa University, College of Pharmacy, Department of Pharmaceutics, Baghdad, Iraq | ||
| 6Department of Pharmacology and Toxicology, College of Pharmacy, University of Alkafeel, Najaf, Iraq | ||
| 7ARCPMS, University of Alkafeel, Najaf, Iraq | ||
| 8Department of Pharmaceutics, College of Pharmacy, University of AlKafeel, Najaf, Iraq | ||
| چکیده | ||
| Bioactive ingredients like Resveratrol (RTL) and Silymarin (SLM), found in natural skincare products, are highly sought after for their anti-inflammatory, skin-protective, and antioxidant properties. However, their poor aqueous solubility limits their effective topical application. Organogels offer a solution by immobilizing and releasing lipophilic compounds within a stable, viscoelastic, semisolid delivery system. This study focused on creating, characterizing, and evaluating RTL and SLM-loaded herbal topical organogels to optimize their skin dispersion and therapeutic availability. Eight organogel formulations (F1-F8) were developed using three phases: drug, oil, and water. Key excipients included soy lecithin (SL) as a permeation enhancer, isopropyl myristate (IPM) as an emollient, and pluronic F127 as a gel stabilizer. Polyethylene glycol (PEG 400) was investigated as a co-solvent and humectant, with SL concentrations ranging from 1% to 6% w/v. The organogels were assessed for gelation temperature, viscosity, drug content uniformity, pH compatibility, and the release of natural ingredients using a dialysis bag over 6 hours. All developed organogels were homogeneous and exhibited an appealing yellow color. They demonstrated physiological skin-compatible pH values (6.1–6.7) and excellent drug content uniformity (95.13%–99.17%). Viscosities ranged from 2943 to 3963 poise, and gelation temperatures from 23°C to 36°C. An increase in SL concentration enhanced matrix viscosity and gelation temperature but also delayed drug release. Conversely, PEG 400, acting as a co-solvent, improved both drug release and solubility. The PEG-free formulation (F3) released 32% of the active ingredients within 6 hours, whereas the optimized formulation (F5), containing PEG, released 90%. Overall, the organogel system demonstrated good physiological pH compatibility, desirable viscoelastic viscosity, and an excellent drug release profile, making it a highly promising method for topical administration in cosmetics and wound healing applications. | ||
| کلیدواژه‌ها | ||
| Organogel؛ Pluronic؛ Resveratrol؛ Silymarin؛ Soya Lecithin | ||
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آمار تعداد مشاهده مقاله: 85 تعداد دریافت فایل اصل مقاله: 68 |
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