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Evaluation of Helicobacter spp. and Wolinella spp. in the Oral Cavity of Dogs with Periodontitis and Screening of the Presence of Helicobacter pylori Virulence Genes in Wolinella-positive Samples by PCR | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 مهر 1405 اصل مقاله (1.03 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.66224/ari.2026.372849.4130 | ||
| نویسندگان | ||
| Zahra Jahanshiri1؛ Bahar Nayeri Fasaei* 2؛ Shahram Jamshidi3؛ Taghi Zahraei Salehi2؛ Iradj Ashrafi Tamai2 | ||
| 1Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran | ||
| 2Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran | ||
| 3Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran | ||
| چکیده | ||
| Introduction: Oral Wolinella spp. have been reported to be more prevalent than closely related Helicobacter spp. in canines. Although Wolinella succinogenes is considered nonpathogenic, complete genome analysis has revealed that it carries several genes homologous to sequences associated with virulence or host interaction in Helicobacter pylori. This study evaluated the prevalence of the genera Wolinella and Helicobacter, and H. pylori in the canine oral cavity in patients suffering from periodontitis and screened selected H. pylori-associated virulence genes babA and cagA in the Wolinella-positive samples. Materials and Methods: Samples were collected from the oral cavity of sixty-two canine patients with periodontitis. PCR assays targeting 16S rRNA were used to detect Wolinella spp. and Helicobacter spp. Samples positive for the genus Helicobacter were further evaluated for H. pylori using the ureC gene. Wolinella-positive samples were screened for the presence of the babA and cagA genes. Results: 52/62 samples were positive for Wolinella spp., whereas Helicobacter spp. were detected in 36/62 dogs. No H. pylori was detected in any Helicobacter-positive oral sample. Neither the babA nor the cagA gene was detected in any Wolinella-positive sample. Conclusion: Wolinella spp. showed a high prevalence and were detected more frequently than Helicobacter spp. in oral samples from dogs with periodontitis. However, babA and cagA were not detected in the oral samples examined in the current study. This suggests that these selected H. pylori-associated virulence genes are unlikely to explain the putative pathogenic relevance of Wolinella spp. in canine periodontitis. | ||
| کلیدواژه‌ها | ||
| Dogs؛ Helicobacter؛ Helicobacter pylori؛ Virulence factors؛ Wolinella | ||
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