| Squamous cell carcinoma (SCC) is one of the most frequently diagnosed cutaneous malignancies in veterinary medicine, with ultraviolet (UV) radiation recognized as the principal etiological factor. Although SCC generally has a favorable prognosis, an accurate diagnosis is essential for selecting the most appropriate therapeutic strategy. This retrospective study evaluated 19 cases of SCC diagnosed between 2013 and 2025. Sex information was available for 16 animals, including 10 female dogs, 4 male dogs, and 2 female cats. The affected animals represented various breeds, including Terrier, German Shepherd, Spitz, Spitz–Terrier crossbreeds, and mixed-breed dogs. The tumors were located in the trunk, tail, inguinal region, mammary glands, nostrils, nasal planum, vagina, submandibular region, oral cavity, neck, perineum, elbow, and frontal region. Histopathological grading identified seven Grade I, five Grade II, and four Grade III SCCs. In addition, three cases were diagnosed as adenosquamous carcinoma, a histological variant of SCC. Histopathological examination revealed a broad spectrum of microscopic changes, including hyperkeratosis, parakeratosis, acanthosis, epithelial dysplasia, keratin pearl formation, lymphoplasmacytic infiltration, cellular pleomorphism, and lymphatic invasion. |