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Use of Escherichia coli bacteriophage to eliminate Shiga toxin-producing Escherichia coli without inducing toxin production | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 مهر 1405 اصل مقاله (774.18 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.66224/ari.2026.373339.4192 | ||
| نویسندگان | ||
| maher saleh1؛ Abdulkarim HALLAK2؛ ASEEM ALBAKER* 2 | ||
| 1Department of Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Hama University, Hama, Syria | ||
| 21Department of Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Hama University, Hama, Syria | ||
| چکیده | ||
| Introduction: Shiga toxin-producing Escherichia coli (STEC) pose a serious health risk, particularly in hemolytic uremic syndrome (HUS) cases, where antibiotic administration may exacerbate the condition by triggering toxin release. This study aimed to investigate the ability of the antibiotic enrofloxacin to induce Shiga toxin production in STEC, and the ability of bacteriophage to eliminate them without inducing toxin secretion. Material and Methods: This study was conducted using bacteriophage isolated from the environment on enterohemorrhagic Escherichia coli (EHEC) isolated from calves. The synergy between enrofloxacin and bacteriophage was studied using the chessboard strip method, and the level of Shiga toxin secretion was measured using ELISA. Results: The results showed a synergistic efficacy between the antibiotic enrofloxacin and bacteriophages, and a strong ability of enrofloxacin to induce toxin production. The results also showed that bacteriophage alone or in synergy with enrofloxacin were able to eliminate bacteria without inducing toxin secretion. Conclusion:We conclude from this the possibility of using bacteriophage as a potential safe alternative in eliminating STEC infection. | ||
| کلیدواژه‌ها | ||
| Bacteriophage؛ Diarrhea؛ Enrofloxacin؛ HUS؛ Shiga toxin؛ STEC | ||
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آمار تعداد مشاهده مقاله: 55 تعداد دریافت فایل اصل مقاله: 64 |
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