The Effect of Eight Weeks of Resveratrol Supplementation on Serum Levels of Adiponectin, Lipocalin-2, Interleukin-10, and CRP in Inactive Obese Middle-Aged Women | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| Article 10, Volume 42, Issue 2 - Serial Number 128, September 2026, Pages 387-397 PDF (1.04 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.22092/ijmapr.2026.369788.3559 | ||
| Authors | ||
| Sara Sepehrzadeh; Roghayyeh Afroundeh* | ||
| Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran | ||
| Abstract | ||
| Background and Objective: Obesity, as a chronic and multifactorial disease, is one of the most important public health challenges in the world, which is associated with increased low-grade chronic inflammation, metabolic disorders, and an increased risk of cardiovascular diseases. Low-grade chronic inflammation in obesity is associated with dysregulated secretion of adipokines and increased inflammatory markers such as C-reactive protein (CRP) and lipocalin-2, along with decreased levels of anti-inflammatory cytokines like interleukin-10 (IL-10). Resveratrol, a natural polyphenol with anti-inflammatory and antioxidant properties, has the potential to modulate these biomarkers. However, evidence regarding the effects of resveratrol supplementation on inflammatory profiles in inactive obese women, particularly in middle age, remains limited. This study aimed to investigate the effect of eight weeks of resveratrol supplementation on serum levels of adiponectin, lipocalin-2, IL-10, and CRP in inactive obese middle-aged women. Methodology: The present study was a semi-experimental trial with a pretest–posttest design including a control group. Twenty inactive obese female volunteers with a body mass index (BMI) greater than 30 kg/m² participated and were randomly assigned to either the experimental group (n = 10) or the control group (n = 10). The experimental group received a daily capsule containing 250 mg of pure resveratrol for eight weeks, administered in a fasting state, while the control group did not receive any intervention. To control for confounding factors, all participants were instructed not to use any medications or supplements during the study period. Blood samples for the assessment of biochemical markers, including adiponectin, lipocalin 2, interleukin 10 (IL 10), and C reactive protein (CRP), were collected one day before the intervention and 48 hours after the final day of supplementation. The Shapiro-Wilk test was used to check the normality of the data distribution, and the Levene test was used to check the homogeneity of variances. Data were analyzed using paired t-tests for within-group comparisons and analysis of covariance (ANCOVA) for between-group differences. A significance level of P < 0.05 was considered for all tests. Results: The results of the paired t-test showed that in the supplement group, the levels of adiponectin and interleukin-10 significantly increased in the post-test compared to the pre-test (both P = 0.001), and the levels of lipocalin-2 and C-reactive protein (both P = 0.001) significantly decreased. The results of the analysis of covariance showed that there was a significant difference between the post-test of the supplement group and the control group for the variables adiponectin (F = 92.49, P = 0.001), interleukin-10 (F = 37.61, P = 0.001), lipocalin-2 (F = 66.42, P = 0.001), and C-reactive protein (F = 12.08, P = 0.001). Conclusion: Significant reductions in lipocalin 2 and C reactive protein, along with significant increases in adiponectin and interleukin 10, indicate a decrease in systemic inflammation, improved metabolic status, and reduced obesity among participants. Overall, resveratrol supplementation may serve as an effective and safe intervention to reduce inflammation, improve metabolic indices, and assist in weight management in middle-aged obese women. Therefore, the use of this supplement under the supervision of a specialist physician is recommended as a complementary strategy for controlling obesity and mitigating its associated complications. | ||
| Keywords | ||
| Antioxidant; adipokine; inflammation; cytokine | ||
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