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Seyyedi, Maryam, Sahebi, Leyla, Ranjbari, Yunes, Rasi, Farnaz, Khalili, Yeganeh, Namvar, Leila, Soleimani, Zahra. (1405). Efficacy of a Traditional Iranian Almond-based Formulation (Prunus dulcis Laog) in Treatment of Resistant Chronic Cough: A Randomized Double-Blind Placebo-Controlled Trial. سامانه مدیریت نشریات علمی, 16(1), 87-92. doi: 10.22034/jmpb.2026.369975.2003
Maryam Seyyedi; Leyla Sahebi; Yunes Ranjbari; Farnaz Rasi; Yeganeh Khalili; Leila Namvar; Zahra Soleimani. "Efficacy of a Traditional Iranian Almond-based Formulation (Prunus dulcis Laog) in Treatment of Resistant Chronic Cough: A Randomized Double-Blind Placebo-Controlled Trial". سامانه مدیریت نشریات علمی, 16, 1, 1405, 87-92. doi: 10.22034/jmpb.2026.369975.2003
Seyyedi, Maryam, Sahebi, Leyla, Ranjbari, Yunes, Rasi, Farnaz, Khalili, Yeganeh, Namvar, Leila, Soleimani, Zahra. (1405). 'Efficacy of a Traditional Iranian Almond-based Formulation (Prunus dulcis Laog) in Treatment of Resistant Chronic Cough: A Randomized Double-Blind Placebo-Controlled Trial', سامانه مدیریت نشریات علمی, 16(1), pp. 87-92. doi: 10.22034/jmpb.2026.369975.2003
Seyyedi, Maryam, Sahebi, Leyla, Ranjbari, Yunes, Rasi, Farnaz, Khalili, Yeganeh, Namvar, Leila, Soleimani, Zahra. Efficacy of a Traditional Iranian Almond-based Formulation (Prunus dulcis Laog) in Treatment of Resistant Chronic Cough: A Randomized Double-Blind Placebo-Controlled Trial. سامانه مدیریت نشریات علمی, 1405; 16(1): 87-92. doi: 10.22034/jmpb.2026.369975.2003

Efficacy of a Traditional Iranian Almond-based Formulation (Prunus dulcis Laog) in Treatment of Resistant Chronic Cough: A Randomized Double-Blind Placebo-Controlled Trial

Journal of Medicinal plants and By-products
مقاله 10، دوره 16، شماره 1، فروردین و اردیبهشت 2027، صفحه 87-92    اصل مقاله (1.02 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2026.369975.2003
نویسندگان
Maryam Seyyedi1؛ Leyla Sahebi* 2؛ Yunes Ranjbari3؛ Farnaz Rasi1؛ Yeganeh Khalili1؛ Leila Namvar1؛ Zahra Soleimani4
1Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Maternal, Fetal and Neonatal Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Chronic cough often persists despite standard treatments, highlighting the need for alternative therapies. Prunus dulcis Laoq, a traditional Iranian herbal formulation, has historically been used for respiratory relief. This study evaluated its efficacy in managing treatment-resistant chronic cough. A randomized, double-blind, placebo-controlled trial was conducted with 100 participants. Patients received either Prunus dulcis Laoq or a placebo for 14 days. Symptom progression was assessed using a validated cough severity questionnaire. Data were analyzed using repeated measures ANOVA and mixed-effects models. The Laoq group showed a significant reduction in cough severity compared to placebo (F = 9.48, p = 0.03). Improvements were consistent across demographic subgroups. No adverse effects were reported, supporting the formulation’s safety. Prunus dulcis Laoq demonstrated clinical efficacy in reducing symptoms of treatment-resistant chronic cough and may serve as a safe complementary therapy. Further studies are recommended to assess its long-term effects and potential broader applications.
کلیدواژه‌ها
Iranian traditional medicine؛ Herbal therapy؛ Chronic cough؛ Randomized controlled trial؛ Complementary medicine
مراجع
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