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Molecular identification of Podospora bulbillosa keratitis with progressive stromal thinning: a case report | ||
| Mycologia Iranica | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 09 تیر 1405 | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22092/mi.2026.372915.1348 | ||
| نویسندگان | ||
| Mehrnaz Atighehchian* 1؛ Koosha Koorehpaz2؛ Sadegh Khodavaisy3؛ Zohreh Abedinifar4؛ Alireza Izadi5؛ Mehran Zarei-Ghanavati2 | ||
| 1Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran, Department of Ophthalmology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran | ||
| 2Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Microbiology Unit, Department of Pathology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 5Department of Medical Parasitology and Mycology, Faculty of Medical Sciences, Shahed University, Tehran, Iran | ||
| چکیده | ||
| Fungal keratitis (FK) is a sight-threatening corneal infection that is particularly prevalent in developing countries. This report describes a case of Podospora bulbillosa keratitis, a rare organism confirmed by polymerase chain reaction (PCR) following negative culture results. A 63-year-old male presented with a well-demarcated yellow-brown stromal infiltration. Microbiological evaluation revealed pigmented septate hyphae; however, culture remained negative, and molecular identification was performed using ITS1-5.8S-ITS2 rDNA sequences, which identified the isolate as Podospora bulbillosa (formerly Cladorrhinum bulbillosum). The patient received intensive topical voriconazole 1% and chlorhexidine 0.2% combined with oral voriconazole. Progressive thinning required cyanoacrylate glue. The infection resolved over three months, leaving a central scar. While infections by this organism have been rarely reported, additional cases are crucial to consolidate knowledge of clinical presentation and potential aggressiveness. This case emphasizes the value of molecular diagnostic tools in detecting unusual pathogens and guiding therapy. | ||
| کلیدواژهها | ||
| Cladorrhinum bulbillosum؛ Fungal keratitis؛ PCR؛ Voriconazole | ||
| مراجع | ||
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