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Kavirimanesh Khanaman, Mahboobeh, Raeiszadeh, Mahboobeh, Mehrabani, Mehrnaz, Amirkhosravi, Arian, Mehrbani, Mehrzad, Farhadi, Faegheh, Mehrabani, Mitra. (1405). Total Phenolic Content, Antioxidant Activity, and Cytotoxicity of Different Extractions of Solenanthus circinnatus Ledeb.. سامانه مدیریت نشریات علمی, 15(6), 678-683. doi: 10.22034/jmpb.2026.372190.2143
Mahboobeh Kavirimanesh Khanaman; Mahboobeh Raeiszadeh; Mehrnaz Mehrabani; Arian Amirkhosravi; Mehrzad Mehrbani; Faegheh Farhadi; Mitra Mehrabani. "Total Phenolic Content, Antioxidant Activity, and Cytotoxicity of Different Extractions of Solenanthus circinnatus Ledeb.". سامانه مدیریت نشریات علمی, 15, 6, 1405, 678-683. doi: 10.22034/jmpb.2026.372190.2143
Kavirimanesh Khanaman, Mahboobeh, Raeiszadeh, Mahboobeh, Mehrabani, Mehrnaz, Amirkhosravi, Arian, Mehrbani, Mehrzad, Farhadi, Faegheh, Mehrabani, Mitra. (1405). 'Total Phenolic Content, Antioxidant Activity, and Cytotoxicity of Different Extractions of Solenanthus circinnatus Ledeb.', سامانه مدیریت نشریات علمی, 15(6), pp. 678-683. doi: 10.22034/jmpb.2026.372190.2143
Kavirimanesh Khanaman, Mahboobeh, Raeiszadeh, Mahboobeh, Mehrabani, Mehrnaz, Amirkhosravi, Arian, Mehrbani, Mehrzad, Farhadi, Faegheh, Mehrabani, Mitra. Total Phenolic Content, Antioxidant Activity, and Cytotoxicity of Different Extractions of Solenanthus circinnatus Ledeb.. سامانه مدیریت نشریات علمی, 1405; 15(6): 678-683. doi: 10.22034/jmpb.2026.372190.2143

Total Phenolic Content, Antioxidant Activity, and Cytotoxicity of Different Extractions of Solenanthus circinnatus Ledeb.

Journal of Medicinal plants and By-products
مقاله 7، دوره 15، شماره 6، بهمن و اسفند 2026، صفحه 678-683    اصل مقاله (824.94 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2026.372190.2143
نویسندگان
Mahboobeh Kavirimanesh Khanaman1، 2؛ Mahboobeh Raeiszadeh3؛ Mehrnaz Mehrabani4؛ Arian Amirkhosravi5؛ Mehrzad Mehrbani6؛ Faegheh Farhadi5؛ Mitra Mehrabani* 5
1Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
3Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran
4Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
5Herbal and Traditional Medicines Research Center, Institute of Pharmaceutical Sciences, Kerman University of Medical Sciences, Kerman, Iran
6Applied cellular and molecular research center, Kerman University of Medical Sciences, Kerman, Iran
چکیده
Azar-Choob, scientifically known as Solenanthus circinnatus Ledeb., belongs to the Boraginaceae family. Traditionally, its root has been used topically for pain relief and to reduce inflammation. The present study aimed to evaluate the antioxidant and cytotoxic effects of various extracts obtained from the roots of Solenanthus circinnatus Ledeb. Following the collection and drying of the plant roots, phytochemical screening was conducted. The dried roots were sequentially extracted using a Soxhlet apparatus with a series of solvents with increasing polarity: n-hexane, dichloromethane, chloroform, ethyl acetate, ethanol, and methanol. The total phenolic content (TPC) of each extract was quantified using the Folin-Ciocalteu assay. Subsequently, the DPPH radical scavenging assay was performed. Finally, the cytotoxic effects of all extracts were assessed on MCF-7, MDA-MB-231, HT-29, A549, and NIH-3T3 fibroblasts via the MTT assay. The highest extraction yield was obtained with the ethanolic extract (25.2 ± 0.85 %). After phytochemical screening, the presence of pyrrolizidine alkaloids, tannins, steroids, and carbohydrates was also confirmed in the plant root. The ethyl acetate extract not only contained the highest TPC but also demonstrated the most potent antioxidant activity. Regarding cytotoxicity, most extracts had no significant effect on cell viability. However, dichloromethane and chloroform extracts at 125 μg/mL significantly reduced the viability of the MDA-MB-231 breast cancer cell line. This study showed that the ethyl acetate extract of Solenanthus circinnatus Ledeb. may be considered a potentially safe and effective natural antioxidant source for further applications in nutraceutical and pharmaceutical industries.
کلیدواژه‌ها
Azar-Choob؛ Solenanthus circinnatus Ledeb؛ antioxidant capacity؛ Cytotoxic effects
مراجع

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