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Screening of Some Rare and Endemic Plants Growing in Iran for Their Cytotoxic Effects on Cancer Cell Lines | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 24 خرداد 1405 اصل مقاله (1.1 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2026.369333.1956 | ||
| نویسندگان | ||
| Asyeh Keivanloo1؛ Elham Ramazani2؛ Seyed Ahmad Emami3؛ Mohammad Sadegh Amiri4؛ Zahra Tayarani-Najaran* 5، 6 | ||
| 1Department of Pharmacognosy, School of Pharmacy, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Biology, Yazd University, Yazd, Iran | ||
| 3Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Department of Biology, Payame Noor University, Tehran, Iran | ||
| 5Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 6Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Khorasan Razavi Province is one of the most significant regions of plant diversity of the flora of Iran. Numerous rare indigenous plant species are grown in this province, which would be suitable potential candidates for assessing cytotoxic activities and apoptosis induction. In this study, we intended to explore the cytotoxic and apoptotic properties of the methanol extract of the root and aerial parts of 10 rare and endemic plants of Khorasan Razavi Province, namely Dorema kopetdaghense, Chaerophyllum khorassanicum, Seseli staurophyllum, Seseli transcaucasicum, Haplophyllum obtusifolium, Crinitaria grimmii, Handelia trichophylla, Rheum turkestanicum, Eremostachys boissieriana, and E. macrophylla, on PC-3, MCF-7, MDA, and B16F10 cancer cells using resazurin and flow cytometry assays. 100 μg/ml of D. kopetdaghense root extract on PC3 (p <0.001), MCF-7 (p <0.001), MDA (p <0.001), B16F10 (p <0.001) cells significantly decreased cell viability. 100 μg/ml of H. obtusifolium root extract on PC3 (p <0.001), MCF-7 (p <0.001), MDA (p <0.05), B16F10 (p <0.001) cells, and 50 μg/ml of H. obtusifolium root extract on MCF-7 (p <0.01), B16F10 (p <0.001) exhibited cytotoxic effects. The histogram obtained from the PI staining and flow cytometry indicated induction of apoptosis by 25 and 50 μg/ml D. kopetdaghense and H. obtusifolium root extracts in the PC3 and MCF-7 cell lines. The root extracts of D. kopetdaghense and H. obtusifolium had significant cytotoxic effects and could induce apoptosis. It suggests that plants with low IC50 values are considered potent cytotoxic species for further evaluation as candidate anti-cancer agents. | ||
| کلیدواژهها | ||
| Dorema kopetdaghense؛ Haplophyllum obtosifolium؛ Cytotoxic؛ Apoptosis | ||
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آمار تعداد مشاهده مقاله: 24 تعداد دریافت فایل اصل مقاله: 21 |
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