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بهینهسازی پارامترهای الکتروریسی برای ساخت نانوالیاف پلیوینیل الکل حاوی عصاره جینسنگ قرمز (Panax ginseng C.A. Meyer)با استفاده از روش سطح پاسخ | ||
| تحقیقات مهندسی صنایع غذایی | ||
| دوره 25، شماره 1 - شماره پیاپی 80، فروردین 1405، صفحه 227-256 اصل مقاله (1.61 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/fooder.2026.372884.1457 | ||
| نویسندگان | ||
| بهداد شکرالهی یانچشمه* 1؛ محمد اکرامی2؛ ملیحه سالاری شورآبی3 | ||
| 1گروه پژوهشی مهندسی تولید مواد غذایی، مؤسسه ملی مواد غذایی، دانشگاه فنی دانمارک، دانمارک | ||
| 2گروه علوم و مهندسی صنایع غذایی، دانشکده مهندسی و فناوری کشاورزی، پردیس کشاورزی و منابع طبیعی، دانشگاه تهران، کرج، ایران | ||
| 3گروه علوم و صنایع غذایی، دانشکده کشاورزی، دانشگاه فردوسی مشهد، مشهد، ایران | ||
| چکیده | ||
| الکتروریسی روشی کارآمد برای تولید نانوحاملهای پلیمری یکنواخت جهت ریزپوشانی ترکیبات زیستفعال است. در این پژوهش، پارامترهای فرآیندی الکتروریسی نانوالیاف پلی(وینیل الکل) بارگذاریشده با عصاره جینسنگ قرمز (Panax ginseng C.A. Meyer) با استفاده از روش سطح پاسخ و طرح مرکب مرکزی بهینهسازی شد. متغیرهای مستقل شامل غلظت عصاره (2 تا 6 درصد حجمی)، ولتاژ اعمالی (12.5 تا 22.5 کیلوولت)، دبی پمپ (0.4 تا 1.2 میلیلیتر بر ساعت) و فاصله نوک تا جمع کننده (15 تا 30 سانتیمتر) بودند. ویژگیهای فیزیکی محلولها و مورفولوژی الیاف با دقت ارزیابی گردید. تحلیل آماری حاکی از آن بود که مدل درجه دوم توسعهیافته از برازش بسیار مطلوبی با دادههای تجربی برخوردار است (0.9977=R2). شرایط بهینه برای تولید نانوحامل یکنواخت با قطر 260 نانومتر، شامل غلظت عصاره 3.5 درصد، فاصله 15 سانتیمتر، ولتاژ 21.5 کیلوولت و دبی 0.75 میلیلیتر بر ساعت بود پیشبینی شد. در این شرایط بهینه، بازده ریزپوشانی عصاره 78.4 درصد بهدست آمد که کارایی بالای این سامانه را نشان میدهد. بررسیها تأیید کرد که تغییرات ویسکوزیته و هدایت الکتریکی محلول ناشی از عصاره، عامل اصلی تعدیل قطر الیاف است. این یافتهها پتانسیل نانوالیاف پلی(وینیل الکل) را برای رهاسازی کنترلشده ترکیبات حساس جینسنگ قرمز تأیید میکند. | ||
| کلیدواژهها | ||
| الکتروریسی؛ جینسنگ قرمز؛ نانوالیاف پلی(وینیل الکل)؛ ریزپوشانی؛ روش سطح پاسخ | ||
| عنوان مقاله [English] | ||
| Optimization of Electrospinning Parameters of Nanofibers Loaded with Red Ginseng Extract (Panax ginseng C.A. Meyer) Using RSM | ||
| نویسندگان [English] | ||
| Behdad Shokrollahi Yancheshmeh1؛ Mohammad Ekrami2؛ Malihe Salari Shorabi3 | ||
| 1Research Group for Food Production Engineering, National Food Institute, Technical University of Denmark, Søltofts Plads 227, 2800, Kongens Lyngby, Denmark | ||
| 2Department of Food Science and Engineering, Faculty of Agricultural Engineering and Technology, Campus of Agriculture and Natural Resources, University of Tehran, Karaj, Iran | ||
| 3Department of Food Science and Technology, School of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| چکیده [English] | ||
| Electrospinning is one of the most suitable techniques to produce uniform polymeric nanocarriers for encapsulating bioactive compounds. In this study, the electrospinning process parameters of poly(vinyl alcohol) nanofibers loaded with red ginseng extract (Panax ginseng C.A. Meyer) were optimized using response surface methodology based on a central composite design. The independent variables comprised extract concentration (2 to 6% v/v), applied voltage (12.5 to 22.5 kV), feed flow rate (0.4 to 1.2 mL/h), and tip-to-collector distance (15 to 30 cm). The physical properties of the electrospinning solutions and fiber morphology were examined. The developed quadratic model showed an excellent fit with the experimental data, as confirmed by statistical analysis (R² = 0.9977). The predicted best condition for the preparation of uniform nanocarriers with a diameter of 260 nm was 3.5% extract concentration, 15 cm tip-to-collector distance, 21.5 kV applied voltage, and 0.75 mL/h feed flow rate.At these conditions, the encapsulation efficiency of the extract in nanofibers reached 78.4%, suggesting that this system could be very promising. In addition, it was found that the extract altered the viscosity and electrical conductivity of the electrospinning solutions, thus affecting the fiber diameter. These results confirmed that polyvinyl alcohol nanofibers could be used as a platform for the controlled release of red ginseng bioactive compounds sensitive to various processing conditions. | ||
| کلیدواژهها [English] | ||
| Electrospinning, Red ginseng, Poly(vinyl alcohol) nanofibers, Encapsulation, Response surface methodology | ||
| مراجع | ||
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Abdelhady, S. S., Atta, M., Megahed, A., Abu-Hasel, K., Alquraish, M., Ali, A. A. & Zoalfakar, S. H. 2022. Modeling electrospun PLGA nanofibers’ diameter using response surface methodology and artificial neural networks. Journal of Industrial Textiles, 52, 15280837221142641 Abdulhussain, R., Adebisi, A., Conway, B. R. & Asare-Addo, K. 2023. Electrospun nanofibers: Exploring process parameters, polymer selection, and recent applications in pharmaceuticals and drug delivery. Journal of Drug Delivery Science and Technology, 90, 105156. Ahmadi Bonakdar, M. & Rodrigue, D. 2024. Electrospinning: processes, structures, and materials. Macromol, 4, 58–103. Al Horani, R. Z., Kepekçi, R. A. & İçoğlu, H. İ. 2024. Bioactive PVA nanofiber mat loaded with artichoke bracts extract as a promising wound dressing biomaterial. Materials Today Communications, 38, 108249. Alimohammadifard, E., Emam-Djomeh, Z. & Ekrami, M. Optimizing the electrospinning process of poly (vinyl alcohol) nanocarrier containing Oxalis corniculata Linn. Alotaibi, F. T., Alamri, M. A., Alneghery, L. M., Alaseem, A. M., El-Desouky, M. G. & El-Bindary, A. A. 2025. Doxorubicin drug delivery using an electrospun nanofiber membrane of chitosan–polycaprolactone with metal–organic framework: Box–Behnken optimization, anticancer treatment, and antimicrobial activity. RSC advances, 15, 49243–49268. Alotaibi, F. T. & El-Bindary, A. A. 2026. Efficient Removal Of The Ciprofloxacin Drug Using An Electrospun Co/Al-Layered Double Hydroxide-Embedded Chitosan/Polyvinylidene Fluoride Nanofiber Membrane. Rsc Advances, 16, 10451–10478. Amer, A. A., Mohammed, R. S., Hussein, Y., Ali, A. S. & Khalil, A. A. 2022. Development Of Lepidium Sativum Extracts/Pva Electrospun Nanofibers As Wound Healing Dressing. Acs Omega, 7, 2.20695-0683. Angel, N., Guo, L., Yan, F., Wang, H. & Kong, L. 2020. Effect Of Processing Parameters On The Electrospinning Of Cellulose Acetate Studied By Response Surface Methodology. Journal Of Agriculture And Food Research, 2, 100015. Asadzadeh, R., Askari, G., Emam-Djomeh, Z. & Ekrami, M. 2024. Optimization Of The Electrospinning Process Of Hybrid Nanocarrier Based On Mung Bean (Vigna Radiate L.) Protein/Poly (Vinyl Alcohol). Food Engineering Research, 23, 165–182. Baykara, T. & Taylan, G. 2021. Coaxial Electrospinning Of Pva/Nigella Seed Oil Nanofibers: Processing And Morphological Characterization. Materials Science And Engineering: B, 265, 115012. Chinnappan, B. A., Krishnaswamy, M., Xu, H. & Hoque, M. E. 2022. Electrospinning Of Biomedical Nanofibers/Nanomembranes: Effects Of Process Parameters. Polymers, 14, 3719. Cho, Y., Baek, J. W., Sagong, M., Ahn, S., Nam, J. S. & Kim, I. D. 2025. Electrospinning And Nanofiber Technology: Fundamentals, Innovations, And Applications. Advanced Materials, 37, 25.00162. Da Cruz, E. P., Jansen, E. T., Fonseca, L. M., Dos Santos Hackbart, H. C., Siebeneichler, T. J., Pires, J. B., Gandra, E. A., Rombaldi, C. V., Da Rosa Zavareze, E. & Dias, A. R. G. 2023. Red Onion Skin Extract Rich In Flavonoids Encapsulated In Ultrafine Fibers Of Sweet Potato Starch By Electrospinning. Food Chemistry, 406, 134954. Ekrami, M., Ekrami, A., Roshani-Dehlaghi, N., Mobahi, N., Emam-Djomeh, Z., Salehi, M., Ovissipour, R. & Kalbasi-Ashtari, A. 2025. Anti-Biofilm Efficacy Of A Salep Mucilage–Based Pad Containing Nanoethosomal Allium Jesdianum Essential Oil Boiss. For Controlling Healthcare-Associated Infections. Bionanoscience, 15, 1–23. Ekrami, M., Yancheshmeh, B. S., Mobahi, N., Roshani-Dehlaghi, N., Ekrami, A., Emam-Djomeh, Z., Salehi, M. & Mohammadifar, M. 2026. Nanophytosomal Encapsulation Of Nepeta Pogonosperma L. Essential Oils For Sustained Release In Electrospun Nanofibers. Innovative Food Science & Emerging Technologies, 104–120. Emam-Djomeh, Z., Ekrami, M., Mobahi, N. & Roshani-Dehlaghi, N. 2025. Surface Characterization Of Bionanocomposites. Characterization Techniques In Bionanocomposites, 85–107. Emam-Djomeh, Z., Mobahi, N., Ekrami, M. & Pourmohammad, E. 2024. Role Of Nanotechnology In Food Industries. Nanotechnology In The Food Industry, 93–110. Emam‐Djomeh, Z., Ekrami, M., Ekrami & Ali 2023a. Overview Of Types Of Materials Used For Food Component Encapsulation. Materials Science And Engineering In Food Product Development, 1, 73–92. Emam‐Djomeh, Z., Ekrami, M. & Ekrami, A. 2023B. Design And Use Of Hydrogels For Food Component Encapsulation. Materials Science And Engineering In Food Product Development, 211–226. Fahimirad, S., Satei, P., Ganji, A. & Abtahi, H. 2023a. Wound Healing Capability Of The Double-Layer Polycaprolactone/Polyvinyl Alcohol-Chitosan Lactate Electrospun Nanofiber Incorporating Echinacea Purpurea Extract. Journal Of Drug Delivery Science And Technology, 87, 104734. Fahimirad, S., Satei, P., Ganji, A. & Abtahi, H. 2023b. Wound Healing Performance Of Pva/Pcl Based Electrospun Nanofiber Incorporated Green Synthetized Cunps And Quercus Infectoria Extracts. Journal Of Biomaterials Science, Polymer Edition, 34, 277–301. Fahimirad, S., Satei, P., Latifi, A., Changizi-Ashtiyani, S., Bahrami, M. & Abtahi, H. 2024. Electrospun Pcl/Pva/Phmb Nanofibers Incorporating Ziziphus Jujuba Fruit Extract As Promising Wound Dressings With Potent Antibacterial And Antidiabetic Properties. Journal Of Biomaterials Science, Polymer Edition, 35, 2484–2505. Feng, L., Shi, P., Zhao, L., Shang, M., Han, Y., Han, N., Liu, Z., Li, S., Zhai, J. & Yin, J. 2024. Structural Characterization Of Polysaccharides From Panax Ginseng Ca Meyer Root And Their Triggered Potential Immunoregulatory And Radioprotective Activities. International Journal Of Biological Macromolecules, 280, 135993. Hamadi, N. B., Guesmi, A., Abd El-Fattah, W., El-Bindary, M. A., El-Desouky, M. G. & El-Bindary, A. A. 2025. Eco-Engineered Electrospun La/Rb-Mof/Chitosan–Pcl Nanofibrous Membrane For High-Performance, Recyclable, And Sustainable Cr (Vi) Removal From Water. Rsc Advances, 15, 44766–44796. Han, E. J., Elbegbayar, E., Baek, Y., Lee, J.-S. & Lee, H. G. 2023. Taste Masking And Stability Improvement Of Korean Red Ginseng (Panax Ginseng) By Nanoencapsulation Using Chitosan And Gelatin. International Journal Of Biological Macromolecules, 250, 126259. Hoseini, M., Hamidi, S., Salehi, E., Mohammadi, A., Mirhoseini, F. & Ravaghi, M. 2024. Multi-Variate Multi-Objective Optimization Of Production Conditions For Electro-Spun Skin Scaffold Using Rsm And Investigation Of Gamma Irradiation Effects On The Properties Of The Optimized Sample. Heliyon, 10. Hosseini, F., Miri, M. A., Najafi, M., Soleimanifard, S. & Aran, M. 2021. Encapsulation Of Rosemary Essential Oil In Zein By Electrospinning Technique. Journal Of Food Science, 86, 4070–4086. Huang, Y., Li, X. & Tan, Z. 2025. Continuous Long-Distance Liquid Transport Along Fibers Arising From Plateau-Rayleigh Instability. Chemical Engineering Science, 312, 121711. Ji, D., Lin, Y., Guo, X., Ramasubramanian, B., Wang, R., Radacsi, N., Jose, R., Qin, X. & Ramakrishna, S. 2024. Electrospinning Of Nanofibres. Nature Reviews Methods Primers, 4, 1. Ji, X., Hou, C., Shi, M., Yan, Y. & Liu, Y. 2022. An Insight Into The Research Concerning Panax Ginseng Ca Meyer Polysaccharides: A Review. Food Reviews International, 38, 1149–1165. Khajavi, R. & Abbasipour, M. 2026. Controlling Nanofibre Morphology By The Electrospinning Process. Electrospun Nanofibers. Elsevier. Kočí, J., Míka Havlík, M., Procházka, V., Klusoňová, N. & Sedláčková, E. 2024. The Effect Of Solution Viscosity On The Quality Of Electroactive Nanofibers Produced By Electrospinning. Monatshefte Für Chemie-Chemical Monthly, 155, 349–352. Kong, L., Chen, P. & Chang, C. 2023. Drought Resistance And Ginsenosides Biosynthesis In Response To Abscisic Acid In Panax Ginseng Ca Meyer. International Journal Of Molecular Sciences, 24, 9194. Kumar, N., Goel, R., Gaur, P. K., Saxena, P. K., Puri, D., Chaudhary, R. & Yasir, M. 2021. Development And Evaluation Of Phytosome-Loaded Microsphere System For Delivery Of Ginseng Extract. Journal Of Microencapsulation, 38, 496–506. Lee, K.-Y., Shim, S.-L., Jang, E.-S. & Choi, S.-G. 2024. Ginsenoside Stability And Antioxidant Activity Of Korean Red Ginseng (Panax Ginseng Ca Meyer) Extract As Affected By Temperature And Time. Lwt, 200, 116205. Li, Z., Wang, C., Li, Z. & Wang, C. 2013. Effects Of Working Parameters On Electrospinning. One-Dimensional Nanostructures: Electrospinning Technique And Unique Nanofibers, 15–28. Malara, A. 2024. Environmental Concerns On The Use Of The Electrospinning Technique For The Production Of Polymeric Micro/Nanofibers. Scientific Reports, 14, 8293. Martins, R., Mouro, C., Pontes, R., Nunes, J. & Gouveia, I. 2023. Natural Deep Eutectic Solvent Extraction Of Bioactive Pigments From Spirulina Platensis And Electrospinning Ability Assessment. Polymers, 15, 1574. Mhetre, H., Kanse, Y. & Chendake, Y. 2023. Influence Of Electrospinning Voltage On The Diameter And Properties Of 1-Dimensional Zinc Oxide Nanofiber. Es Materials And Manufacturing, 20, 838. Min, J.-Y., Lee, Y.-K., Chang, Y. H. & Kwak, H.-S. 2018. Red Ginseng Extract Capsule Fabricated Using W/O/W Emulsion Techniques. International Journal Of Food Properties, 21, 1888–1895. Mirzakhani, M., Ekrami, M. & Moini, S. 2018. Chemical Composition, Total Phenolic Content And Antimicrobial Activities Of Zhumeria Majdae. Journal Of Food And Bioprocess Engineering, 1, 47–52. Mouro, C. & Gouveia, I. C. 2024. Electrospun Wound Dressings With Antibacterial Function: A Critical Review Of Plant Extract And Essential Oil Incorporation. Critical Reviews In Biotechnology, 44, 641–659. Nazemi, M. M., Khodabandeh, A. & Hadjizadeh, A. 2022. Near-Field Electrospinning: Crucial Parameters, Challenges, And Applications. Acs Applied Bio Materials, 5, 394–412. Parın, F. N., Aydemir, Ç. İ., Taner, G. & Yıldırım, K. 2021. Co-Electrospun-Electrosprayed Pva/Folic Acid Nanofibers For Transdermal Drug Delivery: Preparation, Characterization, And In Vitro Cytocompatibility. Journal Of Industrial Textiles, 1528083721997185. Rahbari, S., Tavakolipour, H. & Kalbasi-Ashtari, A. 2024. Application Of Electro-Spraying Technique And Mathematical Modelling For Nanoencapsulation Of Curcumin. Heliyon, 10. Rahma, E., Hernawati, R. M., Dewi, S. A., Achmad, F., Abdullah, F., Mohamad, J. N. & Vidia Putra, V. G. 2026. Analyzing Data Using Artificial Intelligence For Optimization Of Electrospun Polyvinyl Alcohol-Averrhoa Bilimbi Nanofiber Diameters. Journal Of Macromolecular Science, Part B, 65, 432–440. Refate, A., Mohamed, Y., Mohamed, M., Sobhy, M., Samhy, K., Khaled, O., Eidaroos, K., Batikh, H., El-Kashif, E. & El-Khatib, S. 2023. Influence Of Electrospinning Parameters On Biopolymers Nanofibers, With Emphasis On Cellulose & Chitosan. Heliyon, 9. Rêgo, T. R. S., Toledo, A. L. M. M. & Dias, M. L. 2025. Effect Of Processing On The Morphology And Structure Of Plga/Pva Fibers Produced By Coaxial Electrospinning. Processes, 13, 1837. Rezaei, A. & Zebarjad, S. M. 2024. Evaluation Of The Effective Parameters On The Electrospinning Of Polyvinyl Alcohol–Chitosan Nanofibers Using Response Surface Methodology (Rsm). Macromolecular Research, 32, 1005–1027. Rieger, K. A., Birch, N. P. & Schiffman, J. D. 2016. Electrospinning Chitosan/Poly (Ethylene Oxide) Solutions With Essential Oils: Correlating Solution Rheology To Nanofiber Formation. Carbohydrate Polymers, 139, 131–138. Shaban, M., Mosa, T. M., Abdel-Hamid, H., Abdalfarg, N. & Hashim, G. 2026. Advancements In Electrospinning: A Comprehensive Review Of Historical Development, Key Parameters, Applications, And Challenges. Discover Chemistry, 3, 82. Shabani, A., Al, G. A., Berri, N., Castro‐Dominguez, B., Leese, H. S. & Martinez‐Hernandez, U. 2025. Electrospinning Technology, Machine Learning, And Control Approaches: A Review. Advanced Engineering Materials, 27, 2401353. Shahid, M. A. & Khan, M. S. 2022. Preparation And Characterization Of Electrospun Nanofiber Membrane From Polyvinyl Alcohol Loaded With Glycyrrhiza Glabra Extract. Polymers And Polymer Composites, 30, 09673911221109422. Sharma, D., Saha, D. & Satapathy, B. K. 2021. Structurally Optimized Suture Resistant Polylactic Acid (Pla)/Poly (Є-Caprolactone)(Pcl) Blend Based Engineered Nanofibrous Mats. Journal Of The Mechanical Behavior Of Biomedical Materials, 116, 104331. Sharma, G. K. & James, N. R. 2022. Electrospinning: The Technique And Applications. Recent Developments In Nanofibers Research. Intechopen. Sree, S., Patra, A., Prasath, V. A., Kambhampati, V. & Xiao, H.-W. 2025. Innovations In Electrospinning Techniques For Nanomaterial Synthesis And Its Applications In The Field Of Active Food Packaging. Journal Of Future Foods. Stoyanova, N., Nachev, N. & Spasova, M. 2023. Innovative Bioactive Nanofibrous Materials Combining Medicinal And Aromatic Plant Extracts And Electrospinning Method. Membranes, 13, 840. Sukowati, R., Agung, B. H., Rohman, Y. M., Sabandar, M. G., Waresindo, W. X., Hapidin, D. A., Edikresnha, D. & Khairurrijal, K. 2024. Optimization Of Electrospinning Process Parameters Using Box-Behnken Design For Nylon-6 Nanofibers Fabrication. Materials Today: Proceedings. Sukowati, R., Waresindo, W. X. & Hapidin, D. A. Optimization Of Electrospinning Parameters Using Box-Behnken-Based Design Of Experiments (Doe) For The Fabrication Of Ninjaflex/Cacl2 Nanofibers As Potential Application In Flexible Sensors. Journal Of Physics: Conference Series, 2025. Iop Publishing, 012004. Sukpancharoen, S., Wijakmatee, T., Katongtung, T., Ponhan, K., Rattanachoung, N. & Khojitmate, S. 2024. Data-Driven Prediction Of Electrospun Nanofiber Diameter Using Machine Learning: A Comprehensive Study And Web-Based Tool Development. Results In Engineering, 24, 102826. Tekin, M. D., Çelikozlu, S. & Aydin, H. 2023. Electrospun Rocket Seed (Eruca Sativa Mill) Mucilage/Polyvinyl Alcohol Nanofibers: Fabrication And Characterization. Iranian Polymer Journal, 32, 203–211. Theron, S., Zussman, E. & Yarin, A. 2004. Experimental Investigation Of The Governing Parameters In The Electrospinning Of Polymer Solutions. Polymer, 45, 2017–2030. Topuz, F., Abdulhamid, M. A., Holtzl, T. & Szekely, G. 2021. Nanofiber Engineering Of Microporous Polyimides Through Electrospinning: Influence Of Electrospinning Parameters And Salt Addition. Materials & Design, 198, 109280. Xu, W., Zhou, W., Sun, J., Chen, W., Wu, X., Guan, T., Zhao, Y., Yang, P., Hu, Z. & Li, G. 2024. Isolation, Structural Characterization, And Hypoglycemic Activity Of Polysaccharides From The Stems Of Panax Ginseng Ca Meyer. Frontiers In Sustainable Food Systems, 8, 1500278. Zeinali, T., Alemzadeh, E., Zarban, A., Khorashadizadeh, M. & Ansarifar, E. 2021. Fabrication And Characterization Of Jujube Extract‐Loaded Electrospun Polyvinyl Alcohol Nanofiber For Strawberry Preservation. Food Science & Nutrition, 9, 6353–6361. Ziyadi, H., Baghali, M., Bagherianfar, M., Mehrali, F. & Faridi-Majidi, R. 2021. An Investigation Of Factors Affecting The Electrospinning Of Poly (Vinyl Alcohol)/Kefiran Composite Nanofibers. Advanced Composites And Hybrid Materials, 4, 768–779 | ||
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