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بهینه‌سازی پارامترهای الکتروریسی برای ساخت نانوالیاف پلی‌وینیل الکل حاوی عصاره جینسنگ قرمز (Panax ginseng C.A. Meyer)با استفاده از روش سطح پاسخ | ||
| تحقیقات مهندسی صنایع غذایی | ||
| دوره 25، شماره 1 - شماره پیاپی 80، فروردین 1405، صفحه 227-256 اصل مقاله (1.61 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/fooder.2026.372884.1457 | ||
| نویسندگان | ||
| بهداد شکرالهی یانچشمه* 1؛ محمد اکرامی2؛ ملیحه سالاری شورآبی3 | ||
| 1گروه پژوهشی مهندسی تولید مواد غذایی، مؤسسه ملی مواد غذایی، دانشگاه فنی دانمارک، دانمارک | ||
| 2گروه علوم و مهندسی صنایع غذایی، دانشکده مهندسی و فناوری کشاورزی، پردیس کشاورزی و منابع طبیعی، دانشگاه تهران، کرج، ایران | ||
| 3گروه علوم و صنایع غذایی، دانشکده کشاورزی، دانشگاه فردوسی مشهد، مشهد، ایران | ||
| چکیده | ||
| الکتروریسی روشی کارآمد برای تولید نانوحامل‌های پلیمری یکنواخت جهت ریزپوشانی ترکیبات زیست‌فعال است. در این پژوهش، پارامترهای فرآیندی الکتروریسی نانوالیاف پلی(وینیل الکل) بارگذاری‌شده با عصاره جینسنگ قرمز (Panax ginseng C.A. Meyer) با استفاده از روش سطح پاسخ و طرح مرکب مرکزی بهینه‌سازی شد. متغیرهای مستقل شامل غلظت عصاره (2 تا 6 درصد حجمی)، ولتاژ اعمالی (12.5 تا 22.5 کیلوولت)، دبی پمپ (0.4 تا 1.2 میلی‌لیتر بر ساعت) و فاصله نوک تا جمع کننده (15 تا 30 سانتی‌متر) بودند. ویژگی‌های فیزیکی محلول‌ها و مورفولوژی الیاف با دقت ارزیابی گردید. تحلیل آماری حاکی از آن بود که مدل درجه دوم توسعه‌یافته از برازش بسیار مطلوبی با داده‌های تجربی برخوردار است (0.9977=R2). شرایط بهینه برای تولید نانوحامل یکنواخت با قطر 260 نانومتر، شامل غلظت عصاره 3.5 درصد، فاصله 15 سانتی‌متر، ولتاژ 21.5 کیلوولت و دبی 0.75 میلی‌لیتر بر ساعت بود پیش‌بینی شد. در این شرایط بهینه، بازده ریزپوشانی عصاره 78.4 درصد به‌دست آمد که کارایی بالای این سامانه را نشان می‌دهد. بررسی‌ها تأیید کرد که تغییرات ویسکوزیته و هدایت الکتریکی محلول ناشی از عصاره، عامل اصلی تعدیل قطر الیاف است. این یافته‌ها پتانسیل نانوالیاف پلی(وینیل الکل) را برای رهاسازی کنترل‌شده ترکیبات حساس جینسنگ قرمز تأیید می‌کند. | ||
| کلیدواژه‌ها | ||
| الکتروریسی؛ جینسنگ قرمز؛ نانوالیاف پلی(وینیل الکل)؛ ریزپوشانی؛ روش سطح پاسخ | ||
| عنوان مقاله [English] | ||
| Optimization of Electrospinning Parameters of Nanofibers Loaded with Red Ginseng Extract (Panax ginseng C.A. Meyer) Using RSM | ||
| نویسندگان [English] | ||
| Behdad Shokrollahi Yancheshmeh1؛ Mohammad Ekrami2؛ Malihe Salari Shorabi3 | ||
| 1Research Group for Food Production Engineering, National Food Institute, Technical University of Denmark, Søltofts Plads 227, 2800, Kongens Lyngby, Denmark | ||
| 2Department of Food Science and Engineering, Faculty of Agricultural Engineering and Technology, Campus of Agriculture and Natural Resources, University of Tehran, Karaj, Iran | ||
| 3Department of Food Science and Technology, School of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| چکیده [English] | ||
| Electrospinning is one of the most suitable techniques to produce uniform polymeric nanocarriers for encapsulating bioactive compounds. In this study, the electrospinning process parameters of poly(vinyl alcohol) nanofibers loaded with red ginseng extract (Panax ginseng C.A. Meyer) were optimized using response surface methodology based on a central composite design. The independent variables comprised extract concentration (2 to 6% v/v), applied voltage (12.5 to 22.5 kV), feed flow rate (0.4 to 1.2 mL/h), and tip-to-collector distance (15 to 30 cm). The physical properties of the electrospinning solutions and fiber morphology were examined. The developed quadratic model showed an excellent fit with the experimental data, as confirmed by statistical analysis (R² = 0.9977). The predicted best condition for the preparation of uniform nanocarriers with a diameter of 260 nm was 3.5% extract concentration, 15 cm tip-to-collector distance, 21.5 kV applied voltage, and 0.75 mL/h feed flow rate.At these conditions, the encapsulation efficiency of the extract in nanofibers reached 78.4%, suggesting that this system could be very promising. In addition, it was found that the extract altered the viscosity and electrical conductivity of the electrospinning solutions, thus affecting the fiber diameter. These results confirmed that polyvinyl alcohol nanofibers could be used as a platform for the controlled release of red ginseng bioactive compounds sensitive to various processing conditions. | ||
| کلیدواژه‌ها [English] | ||
| Electrospinning, Red ginseng, Poly(vinyl alcohol) nanofibers, Encapsulation, Response surface methodology | ||
| مراجع | ||
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