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Dietary effect of chitosan on immunity, antioxidant status, and immune-related gene expression in juvenile starry sturgeon (Acipenser stellatus) | ||
| Iranian Journal of Fisheries Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 26 اردیبهشت 1405 | ||
| شناسه دیجیتال (DOI): 10.22092/ijfs.2026.135497 | ||
| نویسندگان | ||
| D. Zakeri1؛ J. Pazooki* 1؛ M. Mohseni2؛ S. Jamshidi2 | ||
| 1Department of Animal Sciences and Marine Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran | ||
| 2International Sturgeon Research Institute, Iranian Fisheries Science Research Institute (IFSRI), Agricultural Research, Education and Extension Organization (AREEO), Rasht, Iran | ||
| چکیده | ||
| This study investigated the effects of the dietary supplement chitosan (CH) on various parameters including hematological indices, immune response, liver enzyme levels, antioxidant capacity, and the expression of immune-related genes in juvenile starry sturgeon (Acipenser stellatus). 180 juvenile starry sturgeons with an average weight of 31.90 ± 0.73 g were divided into five feeding groups for 60 days includes: control (CTR), 1.5 g (CH1.5), 3.0 g (CH3.0), 4.5 g (CH4.5), and 6.0 g (CH6.0) of CH powder per kg of a basal diet. Blood analyses conducted after the dietary trial demonstrated that CH significantly increased total red blood cells, white blood cells, hematocrit, and hemoglobin levels, with the highest values recorded in the CH6.0 group. CH enhanced immune responses as evidenced by elevated levels of total protein, albumin, globulin, lysozyme activity, and immunoglobulin, particularly in the CH6.0 group. Additionally, dietary CH reduced serum lipid levels, and the lowest liver enzyme activities were observed in the CH4.5 and CH6.0 groups. CH also stimulated the activity of antioxidant enzymes, with the most pronounced antioxidant activity noted in the CH6.0 group. Moreover, CH improved the regulation of the relative expression of interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) genes in liver, intestine, spleen, and head kidney tissues, with the highest expression levels for both genes recorded in the CH6.0 group. These findings suggest that the inclusion of 6 g kg-1 CH in the diet of starry sturgeon enhances hematological and biochemical parameters, boosts antioxidant capacity and immune response, and supports immune-related gene expression | ||
| کلیدواژهها | ||
| Chitosan؛ Aquaculture؛ Stellate sturgeon؛ Inflammatory genes؛ Real-time PCR | ||
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