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Beyond Hypersensitivity: The Synergistic Cytokine Storm Surge as a Driver of Immune Fragility and Recurrent Flu-like Syndromes | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 فروردین 1405 اصل مقاله (609.2 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2026.372180.4045 | ||
| نویسندگان | ||
| Zeliha Selamoglu* 1؛ Shahid Abbas2؛ Muhammad Raza Naqvi3؛ Maryam Abbas4؛ S Bashir5؛ Faiqa Umar6؛ Aqsa Batool6؛ Zain Malik4؛ Ishrat Azam Khan7؛ Muhammad S. Tahir8؛ Marc Mueller9؛ Ghazala Mansoor10؛ Sidra Bano4 | ||
| 1Nigde Omer Halisdemir University | ||
| 2National Institute of Health, Islamabad | ||
| 3Faqeeh University Hospital, Dubai | ||
| 4Allergy and Asthma Center, Blue Area, Islamabad, Pakistan | ||
| 5Pak Emirates Military Hospital, Rawalpindi, Pakistan | ||
| 6Allergy and Asthma Center, Blue Area, Islamabad, Pakistan. | ||
| 7Westminster Medical Center, DHCC, Dubai, UAE | ||
| 8American Wellness Center, DHCC, Dubai, UAE | ||
| 9Emirates Specialty Hospital, Dubai, UAE | ||
| 10Course, MS Diabetes, University of Chester, UK. | ||
| چکیده | ||
| Introduction: Chronic and continuous exposure to aeroallergens, such as House Dust Mite (HDM), and food allergens triggers a systemic Synergistic Cytokine Storm Surge (SCSS) rather than localized hypersensitivity. Chronic allergic disease is often managed via peripheral symptom suppression such as antihistamines, steroids. The immune system is a distributed, adaptive network that "learns" from environmental exposure. In chronic allergy, this learning becomes pathological, transitioning from a protective response to a state of chronic hyper-vigilance. Continuous exposure to allergens, such as Dermatophagoides pteronyssinus, shifts the system toward a state of Pathological Memory. This pro-inflammatory environment—characterized by elevated IL-6, TNF-alpha, and IL-17—lowers the innate immune threshold, manifesting as recurrent flu-like syndromes and suppressing anti-inflammatory regulators like IL-10. Frequent exposure leads to the generation of specialized Memory B and T-cells that act as sentinels for the inflammatory loop. Materials & Methods: This study outlines how persistent allergen exposure generates pathological memory cells, leading to rapid-response cytokine surges, and proposes. Chronic inflammation and micronutrient deficiencies—specifically Zinc and Vitamin D—lead to the degradation of Tight Junction (TJ) proteins. This allows for the translocation of environmental aeroallergens, antigenic food proteins, and Microbial Endotoxins (LPS) into the systemic circulation. Results: This study introduced the TregMaster Paradigm, a systems biology approach that moves beyond temporary suppression toward permanent immunological re-education. The transition from traditional allergy management to the TregMaster paradigm represents a fundamental shift in clinical immunology. Conclusion: It demonstrates that precision immunology can be successfully implemented in diverse clinical settings, such as Dubai and Pakistan. By using high-sensitivity proxy markers like hs-CRP and Plasma Zinc. | ||
| کلیدواژهها | ||
| IgG4 Shield؛ SCSS Paradigm؛ Sickness Behavior؛ TregMaster Protocol؛ Vagus Nerve | ||
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