| The survival of Cultural Ecosystem Services, specifically Indigenous Knowledge (IK) of medicinal plants in Southern Iran, is undergoing rapid erosion due to accelerated generational shift and modernization. This study moves beyond simple documentation in the Hormozgan biodiversity hotspots (Minab and Rudan counties), aiming to quantify, validate, and identify candidate species for novel phytochemical exploration. Methodology: a comprehensive cross-sectional study was conducted, where deep, semi-structured interviews were performed with 31 Key local informants, focusing on the inter-generational transfer of knowledge. Data on the number of species, preparation methods, and therapeutic uses were analyzed using established quantitative ethnobotanical indices, namely the use reports (UR) relative frequency index (RFC), Cultural index (CI), and the Informant Consensus Factor (ICF), to optimize the pharmacological screening process. Key Findings: A total of 118 medicinal plants species across 44 plant families were registered. Our analyses showed that treatments for Dermatological, gastrointestinal, and respiratory disorders commanded the highest consensus among informants (ICF> 0.90). The ethnobotanical survey demonstrated that the Lamiaceae, Asteraceae and Fabaceae were the most represented and highly utilized plant families, with 1,347 use reports documented across all taxa. The primary plant parts employed in descending order of frequency, were leaves, flowers, fruits, and roots. The predominant preparation methods were decoction, followed by poultice and infusion. These reports were categorized into 14 use categories addressing 79 distinct diseases. The most dominant medicinally utilized plant species were identified as Cynanchum acutum, Cymbopogon iwarancusa, Matricaria aurea, Malva neglecta, and Lawsonia inermis, respectively. Furthermore, 41% of the recorded therapeutic applications were identified as novel indigenous uses not previously documented in any major national or international medicinal plant databases, suggesting a unique biochemical reservoir in the region. Conclusion and implications: The findings provide an immediate roadmap for the targeted screening of active compounds from Minab and Rudan flora. Prioritizing species with the highest cultural weight (high CI) significantly increases the probability of discovering new bioactive molecules. The urgent conservation of this unique IK and its associated botanical reserves is a critical conservation priority that will secure the region's pharmaceutical potential and bio-economy. |
- Organization W.H. WHO traditional medicine strategy 2002-2005: World Health Organization. 2002.
- Hosseini S.H., Bibak H., Ghara A.R., Sahebkar A., Shakeri A. Ethnobotany of the medicinal plants used by the ethnic communities of Kerman province, Southeast Iran. Journal of Ethnobiology and Ethnomedicine. 2021;17(1):31.
- Hosseini S.H., Sadeghi Z., Hosseini S.V., Bussmann R.W. Ethnopharmacological study of medicinal plants in Sarvabad, Kurdistan province, Iran. Journal of Ethnopharmacology. 2022;288:114985.
- Larti M., Mehrabian A., Arabsalmani K., Sarvi A., Alaeifar M. Ethnobotany, conservation and sustainable development. Ethnobiology and Biodiversity Conservation. 2024;1(1):10–20.
- Jahantab E., Hosseini S.H., Sadeghi Z. Ethnobotanical study of medicinal plants, Fasa County, Iran. Journal of Medicinal Plants. 2023;22(86):88–112.
- Hosseini H., Katebi F. Agricultural and weed plants as the main ethnobotanical sources in the Jahrom County, Fars Province, Iran. Journal of Medicinal plants and By-Products. 2023.
- Mojtahedzadeh, pirouz. A look at the historical geography of the Persian Gulf; Iranians in the Persian Gulf. Political and Economic Information. 1994;79.
- Soltanipoor M., Babakhanlou P. Introduction and ecological investigation of aromatic plants of Hormozgan Province. 2006.
- Teka A., Asfaw Z., Demissew S., Van Damme P. Medicinal plant use practice in four ethnic communities (Gurage, Mareqo, Qebena, and Silti), south central Ethiopia. Journal of Ethnobiology and Ethnomedicine. 2020;16(1):27.
- Safa O., Soltanipoor M.A., Rastegar S., Kazemi M., Dehkordi K.N., Ghannadi A. An ethnobotanical survey on hormozgan province, Iran. Avicenna Journal of Phytomedicine. 2013;3(1):64.
- Khatibi R., Saberi M. Bio-climatic classification of Iran by multivariate statistical methods. SN Applied Sciences. 2020;2(10):1694.
- Forman L., Bridson D. The herbarium handbook: Royal Botanic Gardens Kew. 1989;
- Gómez‐Bellver C., Ibáñez N., López‐Pujol J., Nualart N., Susanna A. How photographs can be a complement of herbarium vouchers: A proposal of standardization. Taxon. 2019;68(6):1321–26.
- Heberling J.M., Prather L.A., Tonsor S.J. The changing uses of herbarium data in an era of global change: an overview using automated content analysis. BioScience. 2019;69(10):812–22.
- Davis P. Flora of Turkey and The East Aegean Islands, 1988. 1988;10.
- Ghahreman A. Flora of Iran. Research Institute of Forests and Rangelands. 1975;1.
- Rechinger K.H.E. Flora Iranica. Labiatae. Akademische Druck- u. Verlagsanstalt. 1982;150.
- Alexiades M.N. Collecting ethnobotanical data: an introduction to basic concepts and techniques. Advances in Economic Botany. 1996;10:53–94.
- Martin G.J. Ethnobotany: a methods manual: Routledge. 2010;
- Sadeghi Z., Kuhestani K., Abdollahi V., Mahmood A. Ethnopharmacological studies of indigenous medicinal plants of Saravan region, Baluchistan, Iran. Journal of Ethnopharmacology. 2014;153(1):111–18.
- Staub P.O., Geck M.S., Weckerle C.S., Casu L., Leonti M. Classifying diseases and remedies in ethnomedicine and ethnopharmacology. Journal of Ethnopharmacology. 2015;174:514–19.
- Trotter R.T., II, & Logan, M. H. Informant consensus: A new approach for identifying potentially effective medicinal plants. In N. L. Etkin (Ed.). Plants in indigenous medicine and diet: Biobehavioral Approaches. 1986:91–112.
- Tardío J., Pardo-de-Santayana M. Cultural importance indices: a comparative analysis based on the useful wild plants of Southern Cantabria (Northern Spain). Economic botany. 2008;62(1):24–39.
- Abdelhameed R.F., Ibrahim A.K., Elfaky M.A., Habib E.S., Mahamed M.I., Mehanna E.T., Darwish K.M., Khodeer D.M., Ahmed S.A., Elhady S.S. Antioxidant and anti-inflammatory activity of Cynanchum acutum L. isolated flavonoids using experimentally induced type 2 diabetes mellitus: Biological and in silico investigation for nf-κb pathway/mir-146a expression modulation. Antioxidants. 2021;10(11):1713.
- Kadhim M.J., Saadedin S.M. Anti-biofilm activity of Cynanchum acutum leaves extract and assessing their effect against the virulence gene seg of Staphylococcus aureus bacteria. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases. 2024;31(1):246–57.
- Prasad C., Singh D., Shukla O., Singh U. Cymbopogon jwarancusa-An important medicinal plant: A review. Pharm Innov Journal. 2014;3(6):13–9.
- Yousefbeyk F., Hemmati G., Gholipour Z., Ghasemi S., Evazalipour M., Schubert C., Koohi D.E., Boehm V. Phytochemical analysis, antioxidant, cytotoxic, and antimicrobial activities of golden chamomile (Matricaria aurea (Loefl.) Schultz Bip). Zeitschrift für Naturforschung C. 2022;77(7-8):331–42.
- Akkol E.K., Karpuz B., Türkcanoğlu G., Coşgunçelebi F.G., Taştan H., Aschner M., Khatkar A., Sobarzo-Sánchez E. The phytochemical profile and biological activity of Malva neglecta Wallr. in surgically induced endometriosis model in rats. Molecules. 2022;27(22):7869.
- Al-Snafi A.E. A review on Lawsonia inermis: A potential medicinal plant. International Journal of Current Pharmaceutical Research. 2019;11(5):1–13.
- Batiha G.E.-S., Teibo J.O., Shaheen H.M., Babalola B.A., Teibo T.K.A., Al-Kuraishy H.M., Al-Garbeeb A.I., Alexiou A., Papadakis M. Therapeutic potential of Lawsonia inermis Linn: a comprehensive overview. Naunyn-Schmiedeberg's archives of Pharmacology. 2024;397(6):3525–40.
- Tugume P., Kakudidi E.K., Buyinza M., Namaalwa J., Kamatenesi M., Mucunguzi P., Kalema J. Ethnobotanical survey of medicinal plant species used by communities around Mabira Central Forest Reserve, Uganda. Journal of Ethnobiology and Ethnomedicine. 2016;12(1):5.
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