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Jahan, Ishrat, Saxena, Ayush, Alharthi, Afaf, Hazazi, Ali, Anjum, Farah, Alotaibi, Sarah, Aleissi, Awad, Jaswani, Samriddhi, Islam, Mohammad, Khubaib, Mohd. (1405). Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review. سامانه مدیریت نشریات علمی, 15(3), 298-310. doi: 10.22034/jmpb.2026.369492.1970
Ishrat Jahan; Ayush Saxena; Afaf Alharthi; Ali Hazazi; Farah Anjum; Sarah Alotaibi; Awad F Aleissi; Samriddhi Jaswani; Mohammad Hayatul Islam; Mohd Khubaib. "Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review". سامانه مدیریت نشریات علمی, 15, 3, 1405, 298-310. doi: 10.22034/jmpb.2026.369492.1970
Jahan, Ishrat, Saxena, Ayush, Alharthi, Afaf, Hazazi, Ali, Anjum, Farah, Alotaibi, Sarah, Aleissi, Awad, Jaswani, Samriddhi, Islam, Mohammad, Khubaib, Mohd. (1405). 'Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review', سامانه مدیریت نشریات علمی, 15(3), pp. 298-310. doi: 10.22034/jmpb.2026.369492.1970
Jahan, Ishrat, Saxena, Ayush, Alharthi, Afaf, Hazazi, Ali, Anjum, Farah, Alotaibi, Sarah, Aleissi, Awad, Jaswani, Samriddhi, Islam, Mohammad, Khubaib, Mohd. Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review. سامانه مدیریت نشریات علمی, 1405; 15(3): 298-310. doi: 10.22034/jmpb.2026.369492.1970

Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review

Journal of Medicinal plants and By-products
مقاله 1، دوره 15، شماره 3، مرداد و شهریور 2026، صفحه 298-310    اصل مقاله (1.36 M)
نوع مقاله: Review Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2026.369492.1970
نویسندگان
Ishrat Jahan1؛ Ayush Saxena2؛ Afaf Alharthi3؛ Ali Hazazi4، 5؛ Farah Anjum3؛ Sarah Alotaibi5؛ Awad F Aleissi5؛ Samriddhi Jaswani1؛ Mohammad Hayatul Islam* 6؛ Mohd Khubaib* 1
1Molecular Immunology Laboratory, Integral Centre of Excellence for Interdisciplinary Research, Integral University, Lucknow (226026), U.P., India
2Natural Products and Biofuels Research Lab, Integral Centre of Excellence for Interdisciplinary Research, Integral University, Lucknow (226026), U.P., India
3Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Saudi Arabia
4College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia
5Department of Pathology and Laboratory Medicine, Security Forces Hospital Program, Riyadh, Saudi Arabia
6Centre for Advanced Training and Research (CATR), Lucknow (226022) U.P., India
چکیده
Glycyrrhiza glabra (G. glabra) or licorice is a medicinal plant used traditionally worldwide. It has a rich phytochemical makeup that contains flavonoids, saponins, and coumarins, providing various therapeutic benefits. It has been utilized as traditional medicine to treat multiple conditions such as liver toxicity, gastrointestinal diseases, skin, and allergic disorders. G. glabra, an integral component in Ayurvedic practices, has maintained profound medicinal importance since antiquity. In Ayurveda, it is referred to as "Yashtimadhu," an extraordinary and healing herb known for its effectiveness in treating throat inflammation. G. glabra is mentioned as an ancient herbal medicine in “Bhavprakash Nighantu” (an extensive Sanskrit text which has significance in Ayurveda, the ancient medicinal system). It is referred to as Mulethi (Kalintak and Madhulika), characterized by its sweet taste, substantive digestibility, and cooling properties. Additionally, it has been mentioned as a beneficial remedy for hair, skin, and throat issues, to cure ulcers, bleeding disorders, inflammation, and weakness. The presence of active metabolites such as glabridin, liquiritoside, licochalcone, Beta-sitosterol, glabrene, glycyrrhetic acid, glycyrrhizin, glabrone, and isoliquiritigenin enables G. glabra to exhibit anti-inflammatory, anticancer, antiulcer, hepatoprotective, neuroprotective, antidiabetic, and antioxidant properties. The data for this review article on licorice were collected from diverse sources, including ancient Ayurvedic books, scientific databases, scholarly journals, published papers, books, and pharmacopoeias. Google Scholar, PubMed, and other scientific data repositories were used to collect ethnopharmacological and clinical properties of the G. glabra. This study reviewed traditional uses, phytochemistry, various pharmacological properties, and clinical and scientific evidence of G. glabra. Scientific investigation of the metabolites of G. glabra for their therapeutic properties, with special emphasis on the mechanism of action, has been reviewed and discussed with suitable scientific references. The study highlights the need for additional research to fully comprehend the mechanisms behind the therapeutic effects of licorice and its promise in modern medicine. This review article thoroughly analyzes the pharmacological and phytochemical characteristics of G. glabra, which will serve as a resource for future clinical and fundamental studies. 
کلیدواژه‌ها
Glycyrrhiza glabra L؛ Traditional Uses؛ Anti-diabetic؛ Hepatoprotective؛ Neurodegenerative diseases
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سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب