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Jahan, Ishrat, Saxena, Ayush, Alharthi, Afaf, Hazazi, Ali, Anjum, Farah, Alotaibi, Sarah, Aleissi, Awad, Jaswani, Samriddhi, Islam, Mohammad, Khubaib, Mohd. (1405). Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review. سامانه مدیریت نشریات علمی, 15(3), 298-310. doi: 10.22034/jmpb.2026.369492.1970
Ishrat Jahan; Ayush Saxena; Afaf Alharthi; Ali Hazazi; Farah Anjum; Sarah Alotaibi; Awad F Aleissi; Samriddhi Jaswani; Mohammad Hayatul Islam; Mohd Khubaib. "Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review". سامانه مدیریت نشریات علمی, 15, 3, 1405, 298-310. doi: 10.22034/jmpb.2026.369492.1970
Jahan, Ishrat, Saxena, Ayush, Alharthi, Afaf, Hazazi, Ali, Anjum, Farah, Alotaibi, Sarah, Aleissi, Awad, Jaswani, Samriddhi, Islam, Mohammad, Khubaib, Mohd. (1405). 'Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review', سامانه مدیریت نشریات علمی, 15(3), pp. 298-310. doi: 10.22034/jmpb.2026.369492.1970
Jahan, Ishrat, Saxena, Ayush, Alharthi, Afaf, Hazazi, Ali, Anjum, Farah, Alotaibi, Sarah, Aleissi, Awad, Jaswani, Samriddhi, Islam, Mohammad, Khubaib, Mohd. Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review. سامانه مدیریت نشریات علمی, 1405; 15(3): 298-310. doi: 10.22034/jmpb.2026.369492.1970

Therapeutic and Pharmacological Efficacy of Glycyrrhiza glabra L.: An Updated Review

Journal of Medicinal plants and By-products
مقاله 1، دوره 15، شماره 3، مرداد و شهریور 2026، صفحه 298-310    اصل مقاله (1.36 M)
نوع مقاله: Review Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2026.369492.1970
نویسندگان
Ishrat Jahan1؛ Ayush Saxena2؛ Afaf Alharthi3؛ Ali Hazazi4، 5؛ Farah Anjum3؛ Sarah Alotaibi5؛ Awad F Aleissi5؛ Samriddhi Jaswani1؛ Mohammad Hayatul Islam* 6؛ Mohd Khubaib* 1
1Molecular Immunology Laboratory, Integral Centre of Excellence for Interdisciplinary Research, Integral University, Lucknow (226026), U.P., India
2Natural Products and Biofuels Research Lab, Integral Centre of Excellence for Interdisciplinary Research, Integral University, Lucknow (226026), U.P., India
3Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Saudi Arabia
4College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia
5Department of Pathology and Laboratory Medicine, Security Forces Hospital Program, Riyadh, Saudi Arabia
6Centre for Advanced Training and Research (CATR), Lucknow (226022) U.P., India
چکیده
Glycyrrhiza glabra (G. glabra) or licorice is a medicinal plant used traditionally worldwide. It has a rich phytochemical makeup that contains flavonoids, saponins, and coumarins, providing various therapeutic benefits. It has been utilized as traditional medicine to treat multiple conditions such as liver toxicity, gastrointestinal diseases, skin, and allergic disorders. G. glabra, an integral component in Ayurvedic practices, has maintained profound medicinal importance since antiquity. In Ayurveda, it is referred to as "Yashtimadhu," an extraordinary and healing herb known for its effectiveness in treating throat inflammation. G. glabra is mentioned as an ancient herbal medicine in “Bhavprakash Nighantu” (an extensive Sanskrit text which has significance in Ayurveda, the ancient medicinal system). It is referred to as Mulethi (Kalintak and Madhulika), characterized by its sweet taste, substantive digestibility, and cooling properties. Additionally, it has been mentioned as a beneficial remedy for hair, skin, and throat issues, to cure ulcers, bleeding disorders, inflammation, and weakness. The presence of active metabolites such as glabridin, liquiritoside, licochalcone, Beta-sitosterol, glabrene, glycyrrhetic acid, glycyrrhizin, glabrone, and isoliquiritigenin enables G. glabra to exhibit anti-inflammatory, anticancer, antiulcer, hepatoprotective, neuroprotective, antidiabetic, and antioxidant properties. The data for this review article on licorice were collected from diverse sources, including ancient Ayurvedic books, scientific databases, scholarly journals, published papers, books, and pharmacopoeias. Google Scholar, PubMed, and other scientific data repositories were used to collect ethnopharmacological and clinical properties of the G. glabra. This study reviewed traditional uses, phytochemistry, various pharmacological properties, and clinical and scientific evidence of G. glabra. Scientific investigation of the metabolites of G. glabra for their therapeutic properties, with special emphasis on the mechanism of action, has been reviewed and discussed with suitable scientific references. The study highlights the need for additional research to fully comprehend the mechanisms behind the therapeutic effects of licorice and its promise in modern medicine. This review article thoroughly analyzes the pharmacological and phytochemical characteristics of G. glabra, which will serve as a resource for future clinical and fundamental studies. 
کلیدواژه‌ها
Glycyrrhiza glabra L؛ Traditional Uses؛ Anti-diabetic؛ Hepatoprotective؛ Neurodegenerative diseases
مراجع
  1. Jahan F., Alvi S.S., Islam M.H. Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications. Pharmacological Research - Modern Chinese Medicine. 2022;5:100184.
  2. Pastorino G., Cornara L., Soares S., Rodrigues F., Oliveira M.B.P. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy Research. 2018;32:2323-2339.
  3. Wang S., Alafifi J.H., Chen Q., Shen X., Bi C., Wu Y., Yang Z., others. Three New Compounds, Licopyranol A-C, Together with Eighteen Known Compounds Isolated from Glycyrrhiza glabra L. and Their Antitumor Activities. Metabolites. 2022;12:896.
  4. Sharifi-Rad M., Fokou P.V.T., Sharopov F., Martorell M., Ademiluyi A.O., Rajkovic J., Sharifi-Rad J. Antiulcer agents: From plant extracts to phytochemicals in healing promotion. Molecules. 2018;23(7):1751.
  5. Rizzato G., Scalabrin E., Radaelli M., Capodaglio G., Piccolo O. A new exploration of licorice metabolome. Food Chemistry. 2017;221:959-968.
  6. Bhandari S., Ojha N. Therapeutic Effects of Glycyrrhiza glabra Linn. International Journal of Ayurveda and Pharma Research. 2023;39-49.
  7. Dawid-Pać R. Medicinal plants used in treatment of inflammatory skin diseases. Advances in Dermatology and Allergology. 2013;30(3):170-177.
  8. Wahab S., Annadurai S., Abullais S.S., Das G., Ahmad W., Ahmad M.F., Kandasamy G., Vasudevan R., Ali M.S., Amir M. Glycyrrhiza glabra (Licorice): A comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology. Plants. 2021;10:2751.
  9. Mohanta A., Pandey A., Chelladurai P.K., Swamy C.T. Secondary Metabolites: Extraction, Identification, and Commercial Uses. In: Liquorice. CRC Press; 2025. p. 78-103.
  10. Batiha G.E.S., Beshbishy A.M., El-Mleeh A., Abdel-Daim M.M., Devkota H.P. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae). Biomolecules. 2020;10(3):352.
  11. Rasool A., Dar T.A. Glycyrrhizin and its derivatives: An emerging secondary metabolite arsenal of Glycyrrhiza glabra. Medicinal Chemistry Research. 2025;34(4):745-763.
  12. Rehman M.U., Farooq A., Ali R., Bashir S., Bashir N., Majeed S., Taifa S., Ahmad S.B., Arafah A., Sameer A.S., Khan R. Preclinical evidence for the pharmacological actions of glycyrrhizic acid: a comprehensive review. Current Drug Metabolism. 2020;21:436-465.
  13. Hasan M.K., Ara I., Mondal M.S.A., Kabir Y. Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra. Heliyon. 2021;7:e07240.
  14. Kiyama R. Estrogenic flavonoids and their molecular mechanisms of action. The Journal of nutritional Biochemistry. 2023;114:109250.
  15. Chen J.J., Cheng M.J., Shu C.W., Sung P.J., Lim Y.P., Cheng L.Y., Chen L.C., others. A new chalcone and antioxidant constituents of Glycyrrhiza glabra. Chemistry of Natural Compounds. 2017;53:632-634.
  16. Wu Y., Zhou H., Wei K., Zhang T., Che Y., Nguyễn A.D., Pandita S., Wan X., Cui X., Zhou B., Li C. Structure of a new Glycyrrhiza polysaccharide and its immunomodulatory activity. Frontiers in Immunology. 2022;13.
  17. Gendy A.M., El-Sadek H.M., Amin M.M., Ahmed K.A., El-Sayed M.K., El-Haddad A.E., Soubh A. Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats. Life Sciences. 2023;314:121317.
  18. Baltina L.A., Sapozhnikova T.A., Khisamutdinova R.Y., Mikhailova L.R., Kondratenko R.M. Antiulcer Activity of 3-Hydroxyimino Derivatives of Minor Triterpenoids of Licorice Root. Pharmaceutical Chemistry Journal. 2022;56:163-166.
  19. Guo Z., Niu X., Xiao T., Lu J., Li W., Zhao Y. Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch). Journal of Functional Foods. 2015;14:324-336.
  20. Guo Y., Wu Y., Huang T., Huang D., Zeng Q., Wang Z., Liu Q., others. Licorice flavonoid ameliorates ethanol-induced gastric ulcer in rats by suppressing apoptosis via PI3K/AKT signaling pathway. Journal of Ethnopharmacology. 2024;117739.
  21. Liu F., Tang X., Mao B., Zhang Q., Zhao J., Cui S., Chen W. Ethanol extract of licorice alleviates HFD-induced liver fat accumulation in association with modulation of gut microbiota and intestinal metabolites in obesity mice. Nutrients. 2022;14:4180.

 

  1. Bahadori Ganjabadi P., Farzaneh M., Mirjalili M.H. Development and Optimization of Culture Medium for the Production of Glabridin by Aspergillus eucalypticola: An Endophytic Fungus Isolated from Glycyrrhiza glabra L. (Fabaceae). Mycobiology. 2023;51:230-238.
  2. Mohamed D.D., Mahrous H., Khalil H., Ibrahim I.A., Mohamed D.D., Keshk O.S., Nada A.H., Abd El Maksoud A.I. Regulation of angiogenesis and inflammatory pathways by glycyrrhizic acid. Egyptian Journal of Dermatology and Venerology. 2024;44:80-89.
  3. Harini S., Subhabrata M., Rajeshkumar S. Comparative evaluation of Glycyrrhiza glabra incorporated soft-liner over conventional soft-liner based on antimicrobial activity, anti-inflammatory efficacy, surface roughness, wettability, and tensile bond strength: An in vitro study. Journal of International Oral Health. 2023;15:290-297.
  4. Kim H.J., Jang H.N., Bae J.Y., Ha J.H., Park S.N. Antimicrobial activity, quantification and bactericidal activities of licorice active ingredients. Microbiology and Biotechnology Letters. 2014;42:386-392.
  5. Saeed M.K., Zahra N., Saeed A., Shahzad K., Nawaz S., Abidi S.H.I., Syed Q. Antimicrobial and antioxidant properties of water and methanolic extract of G. glabra native to Pakistan. Chemistry International. 2023;9:61-67.
  6. Sathyamoorthy Y., Kaliappan K., Nambi P., Radhakrishnan R. Glycyrrhizic acid renders robust neuroprotection in rodent model of vascular dementia by controlling oxidative stress and curtailing cytochrome-c release. Nutritional Neuroscience. 2020;23:955-970.
  7. Wang Z.F., Liu J., Yang Y.A., Zhu H.L. A review: the anti-inflammatory, anticancer and antibacterial properties of four kinds of licorice flavonoids isolated from licorice. Current Medicinal Chemistry. 2020;27:1997-2011.
  8. Shakya A., Kumar K. Critical Review on Phytoconstituents and Pharmacological Activity of Glycyrrhiza glabra. Pharmacognosy Research. 2025;17(3).
  9. Ha Y., Wang T., Li J., Li J., Lu R., Li J., Gan P., others. Herb-drug interaction potential of licorice extract and paclitaxel: A pharmacokinetic study in rats. European Journal of Drug Metabolism and Pharmacokinetics. 2020;45:257-264.
  10. Liu J., Banuvar S., Viana M., Barengolts E., Chen S.N., Pauli G.F., Van Breemen R.B. Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants. Drug Metabolism and Disposition. 2023;51:199-204.
  11. Cao M., Zuo J., Yang J.G., Wu C., Yang Y., Tang W., Zhu L. Physiology-based pharmacokinetic study on 18β-glycyrrhetic acid mono-glucuronide (GAMG) prior to glycyrrhizin in rats. Molecules. 2022;27:4657.
  12. Mano Y., Abe K., Takahashi M., Higurashi T., Kawano Y., Miyazaki S., Maeda-Minami A. Optimal Administration of Glycyrrhizin Avoids Pharmacokinetic Interactions With High-dose Methotrexate and Exerts a Hepatoprotective Effect. Anticancer Research. 2023;43:1493-1501.
  13. Danaboina G., Mishra S., Sharma D., Kumar A., Mehra V., Kumar R., others. Targeted enrichment of Glycyrrhiza glabra root extract and bioactive compound(s) quantification-A potential scaffold for phytopharmaceutical ingredient development. Chinese Journal of Analytical Chemistry. 2023;51(5):100247.
  14. Kaur R., Kaur H., Dhindsa A.S. Glycyrrhiza glabra: a phytopharmacological review. International Journal of Pharmaceutical Sciences and Research. 2013;4:2470-2477
  15. Kumar Anil K.A., Dora Jyotsna D.J. Review on Glycyrrhiza glabra (Liquorice). 2012.
  16. Menon S., Lavagale P., Maru S., Bari K., Dasmohapatra A. An Ayurvedic Drug Review of Yashtimadhu (Glycyrrhiza glabra L.). Journal of Neonatal Surgery. 2025;14(18s):742.
  17. Mendes-Silva W., Assafim M., Ruta B., Monteiro R.Q., Guimarães J.A., Zingali R.B. Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor. Thrombosis Research. 2003;112:93-98.
  18. Bhuiyan M.Y.H., Islam R., Bhuiyan S.M., Islam A.B.M. Standardization, quality control and pharmacological review on Glycyrrhiza glabra L. A potential medicinal herb in Unani and Ayurvedic systems of medicine. Hamdard Medicine. 2015;58:45-72.
  19. Dastagir G., Rizvi M.A. Glycyrrhiza glabra L. (Liquorice). Pakistan Journal of Pharmaceutical Sciences. 2016;29:1727-1733
  20. Arase Y., Ikeda K., Murashima N., Chayama K., Tsubota A., Koida I., Suzuki Y., Saitoh S., Kobayashi M., Kumada H. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer. 1997;79:1494-1500.
  21. Fenwick G.R., Lutomski J., Nieman C. Liquorice, Glycyrrhiza glabra L. Composition, uses and analysis. Food Chemistry. 1990;38:119-143.
  22. Nesar A., Khalid M., Juber A., Mujahid M., Badruddin M.A., Nazma K. Glycyrrhiza glabra: for traditional uses and pharmacological actions. Advanced Journal of Pharmacie and Life Sciences Research. 2016;4:23-32.
  23. F., Puja M., Adi P., Wiwied E. Pharmacological Effects of Glycyrrhiza glabra L. as Antihepatitis and Hepatoprotective for Children. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia. 2023;10:126-140.
  24. Kumar S., Dhankhar H., Dinodia N., Kumari S. A Review on Phytochemicals and Pharmacological effects reported in Glycyrrhiza glabra (Mulethi). Ecology Environment and Conservation. 2023;29:423-430
  25. Liu M., Fu L., Fu H., Chen Y., Wu M., Liu H. Pharmacological underlying mechanisms of the anticancer effect of licorice: Bioinformatics and experimental verification. Journal of Holistic Integrative Pharmacy. 2024;5:45-55.
  26. Farooqui A., Khan F., Khan I., Ansari I.A. Glycyrrhizin induces reactive oxygen species-dependent apoptosis and cell cycle arrest at G0/G1 in HPV18+ human cervical cancer HeLa cell line. Biomedicine & Pharmacotherapy. 2018;97:752-764.
  27. Ahmad R., Alqathama A., Aldholmi M., Riaz M., Mukhtar M.H., Aljishi F., Alshowaiki M., others. Biological Screening of Glycyrrhiza glabra L. from Different Origins for Antidiabetic and Anticancer Activity. Pharmaceuticals. 2022;16:7.
  28. Bisht D., Rashid M., Arya R.K.K., Kumar D., Chaudhary S.K., Rana V.S., Sethiya N.K. Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight. Phytomedicine Plus. 2022;2(1):100206.
  29. Ah H.P., Nachiammai N. Anticancer Effect of Plectranthus Amboinicus and Glycyrrhiza glabra on Oral Cancer Cell Line: An In vitro Experimental Study. Asian Pacific journal of cancer prevention. 2023;24:881.
  30. Basar N., Oridupa O., Ritchie K., Nahar L., Osman N., Stafford A., Kushiev H., Kan A., Sarker S. Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells. Phytotherapy Research. 2015;29:944-948.
  31. Gioti K., Papachristodoulou A., Benaki D., Beloukas A., Vontzalidou A., Aligiannis N., Tenta R., others. Glycyrrhiza glabra-enhanced extract and adriamycin antiproliferative effect on PC-3 prostate cancer cells. Nutrition and cancer. 2020;72:320-332.
  32. Goel B., Sharma A., Tripathi N., Bhardwaj N., Sahu B., Kaur G., Jain S.K., others. In-vitro antitumor activity of compounds from Glycyrrhiza glabra against C6 glioma cancer cells: identification of natural lead for further evaluation. Natural Product Research. 2021;35:5489-5492.
  33. Nourazarian S.M., Nourazarian A., Majidinia M., Roshaniasl E. Effect of root extracts of medicinal herb Glycyrrhiza glabra on HSP90 gene expression and apoptosis in the HT-29 colon cancer cell line. Asian Pacific journal of cancer prevention. 2016;16:8563-8566.
  34. Basist P., Zahiruddin S., Khan M.U., Gautam G., Jan B., Khan M.A., Ahmad S., others. Metabolite profiling and nephroprotective potential of Glycyrrhiza glabra L. roots against cisplatin-induced nephrotoxicity in vitro and in vivo. Iranian Journal of Basic Medical Sciences. 2022;25:1286.
  35. Tuli H.S., Garg V.K., Mehta J.K., Kaur G., Mohapatra R.K., Dhama K., Sak K., Kumar A., Varol M., Aggarwal D., Anand U. Licorice (Glycyrrhiza glabra L.)-derived phytochemicals target multiple signaling pathways to confer oncopreventive and oncotherapeutic effects. OncoTargets and Therapy. 2022;15:1419.
  36. Hashem A., Esawy R., Lebda M. Protective effect of licorice (Glycyrrhiza glabra Linn) on indomethacin-induced gastric ulcer in male albino rats. Biochemistry Letters. 2018;14:187-201.
  37. Murugan S.K., Bethapudi B., Raghunandhakumar S., Purusothaman D., Nithyanantham M., Mundkinajeddu D., Talkad M.S. A flavonoid rich standardized extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression. BMC complementary medicine and therapies. 2022;22:1-14.
  38. Goorani S., Zhaleh M., Zangeneh A., Koohi M., Rashidi K., Moradi R., Zangeneh M. The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats. Comparative Clinical Pathology. 2018;28:339-347.
  39. Jalilzadeh-Amin G., Najarnezhad V., Anassori E., Mostafavi M., Keshipour H. Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice. Iranian Journal of Pharmaceutical Research: IJPR. 2015;14:1163-1170.
  40. Sohail M., Rakha A., Butt M.S., Asghar M. Investigating the antioxidant potential of licorice extracts obtained through different extraction modes. Journal of Food Biochemistry. 2018;42:e12466.
  41. Dong Y., Zhao M., Zhao T., Feng M., Chen H., Zhuang M., Lin L. Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H2O2-Injured PC12 Cells of Glycyrrhiza glabra L. Leaf and Root Extracts. Molecules. 2014;19:9101-9113.
  42. Velvizhi S., Annapurani S. Estimation of total flavonoid, phenolic content, and free radical scavenging potential of Glycyrrhiza glabra root extract. Asian Asian Journal of Pharmaceutical and Clinical Research. 2018;11:231-235.
  43. Singh V., Kumar A. Antioxidant Potential of roots: In-Vitro Evidences. Journal of Pharmaceutical Technology, Research and Management. 2020;8:9-13.
  44. Jain S. Protective effect of Glycyrrhiza glabra Linn in aniline-induced spleen toxicity in rats. International Journal of Pharmaceutical & Biological Archive.2022;13:165-172
  45. Babich O., Ivanova S., Ulrikh E., Popov A., Larina V., Frolov A., Prosekov A. Study of the Chemical Composition and Biologically Active Properties of Glycyrrhiza glabra Extracts. Life. 2022;12:1772.
  46. Amal C., Syam R.J., Jojan J.V., J.S. Ethnopharmacological study about Glycyrrhiza glabra L. (Licorice) based Ayurveda, An Indian Syst. Tradit. Med. A Review. International Journal of Ayurvedic Medicine. 2022;13:587-600.
  47. Yang L., Jiang Y., Zhang Z., Hou J., Tian S., Liu Y. The anti-diabetic activity of licorice, a widely used Chinese herb. Journal of ethnopharmacology. 2020;263:113216.
  48. Jean M.B. Licorice (Glycyrrhiza glabra). Medicinal Herbs in Primary Care. 2022;475-488.
  49. Suri J.S., Agarwal S., Gupta S.K., Puvvula A., Biswas M., Saba L., Bit A., Tandel G.S., Agarwal M., Patrick A. A narrative review on characterization of acute respiratory distress syndrome in COVID-19-infected lungs using artificial intelligence. Computers in Biology and Medicine. 2021;130:104210.
  50. Ota A., Ulrih N.P. An overview of herbal products and secondary metabolites used for management of type two diabetes. Frontiers in pharmacology. 2017;8:436.
  51. Li D., Fan J., Du L., Ren G. Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways. Archives of Pharmacal Research. 2024;47:127-145.
  52. Cheng H.S., Yaw H.P., Ton S.H., Choy S.M., Kong J.M.X.F., Kadir K.A. Glycyrrhizic acid prevents high calorie diet-induced metabolic aberrations despite the suppression of peroxisome proliferator-activated receptor γ expression. Nutrition. 2016;32:995-1001.
  53. Wong Y.F., Cacciola F., Fermas S., Riga S., James D., Manzin V., Mondello L., others. Untargeted profiling of Glycyrrhiza glabra extract with comprehensive two-dimensional liquid chromatography-mass spectrometry using multi-segmented shift gradients in the second dimension: Expanding the metabolic coverage. Electrophoresis. 2018;39:1993-2000.
  54. Hongtao T., Junqi C., Yicong L., Yingshan L., Yunchang Z., Guangzhao L., Lingling L., Yiqun L. Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways. Molecular Medicine. 2022;28.
  55. Zhang W., Li T., Zhang X.J., Zhu Z.Y. Hypoglycemic effect of glycyrrhizic acid, a natural non-carbohydrate sweetener, on streptozotocin-induced diabetic mice. Food and Function. 2020;11(5):4160-4170.
  56. Chen K., Yang R., Shen F.-Q., Zhu H.-L. Advances in pharmacological activities and mechanisms of glycyrrhizic acid. Current medicinal chemistry. 2020;27:6219-6243.
  57. Guo Z., Niu X., Xiao T., Lu J., Li W., Zhao Y. Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch). Journal of Functional Foods. 2015;14:324-336.
  58. Tiwari K., Alim H. Determination of anti-diabetic and anti-oxidant activity of Glycyrrhiza glabra root extracts and its phytochemical screening. International journal of applied chemical and biological sciences. 2020;1:38-45.
  59. Sharma D., Namdeo P., Singh P. Phytochemistry & pharmacological studies of Glycyrrhiza glabra: A medicinal plant review. International Journal of Pharmaceutical Sciences Review Research. 2021;67:187-194.
  60. Sri H., Maiti S., Shanmugam R. Comparative evaluation of Glycyrrhiza glabra incorporated soft-liner over conventional soft-liner based on antimicrobial activity, anti-inflammatory efficacy, surface roughness, wettability, and tensile bond strength: An in vitro study. Journal of International Oral Health. 2023;15:290-297.
  61. Bairagi R., Patil S. Glycyrrhiza glabra assisted green synthesis of metallic nanoparticles with different applications: A review. International Journal of Life Science Research Archive. 2023;4:36-39.
  62. Chakotiya A.S., Tanwar A., Narula A., Sharma R.K. Alternative to antibiotics against Pseudomonas aeruginosa: Effects of Glycyrrhiza glabra on membrane permeability and inhibition of efflux activity and biofilm formation in Pseudomonas aeruginosa and its in vitro time-kill activity. Microbial pathogenesis. 2016;98:98-105.
  63. Li A., Zhao Z., Zhang S., Zhang Z., Shi Y. Fungicidal activity and mechanism of action of glabridin from Glycyrrhiza glabra L. International Journal of Molecular Sciences. 2021;22:10966.
  64. Wu S.C., Yang Z.Q., Liu F., Peng W.J., Qu S.Q., Li Q., Shen J.Z., others. Antibacterial effect and mode of action of flavonoids from licorice against methicillin-resistant Staphylococcus aureus. Frontiers in Microbiology. 2019;10:467228.
  65. Pellati D., Fiore C., Armanini D., Rassu M., Bertoloni G. In vitro effects of glycyrrhetinic acid on the growth of clinical isolates of Candida albicans. Phytotherapy Research. 2009;23:572-574.
  66. Dai X., Feng J., Chen Y., Huang S., Shi X., Liu X., Sun Y. Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives. Chinese medicine. 2021;16:1-7.
  67. Tsai J., Pan P., Hsu F., Chung J., Chiang I. Glycyrrhizic acid modulates apoptosis through extrinsic/intrinsic pathways and inhibits protein kinase B- and extracellular signal-regulated kinase-mediated metastatic potential in hepatocellular carcinoma in vitro and in vivo. The American Journal of Chinese Medicine. 2020;48:223-244.
  68. Goorani S., Morovvati H., Seydi N., Almasi M., Amiri-Paryan A., Nazari F., Zangeneh M., Zangeneh A. Hepatoprotective and cytotoxicity properties of aqueous extract of Glycyrrhiza glabra in Wistar rats fed with high-fat diet. Comparative Clinical Pathology. 2019;1-8.
  69. Aldhahrani A., Soliman M.M., Althobaiti F., Alkhedaide A., Nassan M.A., Mohamed W.A., Youssef G.B., Said A.M. The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress. Toxicology research. 2021;10:677-686.
  70. Sharma V., Agrawal R. In vivo antioxidant and hepatoprotective potential of Glycyrrhiza glabra extract on carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity. International Journal of Research in Medical Sciences. 2014;2:314-320.
  71. Yasunari T., Kondo Y., Lambino R., Mallee H., Onishi Y., Taniguchi M., Tayasu I. Transdisciplinarity at the Research Institute for Humanity and Nature, Kyoto, Japan. Handbook of Transdisciplinarity: Global Perspectives. Edward Elgar Publishing; 2023. p. 419-435.
  72. Chauhan P., Sharma H., Kumar U., Mayachari A., Sangli G., Singh S. Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: an experimental approach. Journal of Ethnopharmacology. 2020;113209.
  73. Yang Y., Yang L., Han Y., Wu Z., Chen P., Zhang H., Zhou J. Protective effects of hepatocyte-specific glycyrrhetic derivatives against carbon tetrachloride-induced liver damage in mice. Bioorganic Chemistry. 2017;72:42-50.
  74. Fadhil A.F.S., Kamal Y.M., Waheed H.J. The hepatoprotective effect of Glycyrrhiza glabra roots extract against amiodarone induced hepatotoxicity in male rats. Iraqi Journal of Pharmaceutical Sciences. 2024;33:190-196.
  75. Paudel Y.N., Angelopoulou E., Semple B., Piperi C., Othman I., Shaikh M.F. Potential neuroprotective effect of the HMGB1 inhibitor glycyrrhizin in neurological disorders. ACS Chemical Neuroscience. 2020;11:485-500.
  76. Eltahir A.O.E., Omoruyi S.I., Augustine T.N., Luckay R.C., Hussein A.A. Neuroprotective effects of Glycyrrhiza glabra total extract and isolated compounds. Pharmaceuticals. 2024;17:852.
  77. Luo L., Jin Y., Kim I.D., Lee J.K. Glycyrrhizin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. Experimental neurobiology. 2013;22:107.
  78. Azarakhsh M., Hamidi F., Mohebalian H. P13: Anti-inflammatory effect of glycyrrhizin on TNF-α produced by inflamed microglia cell (BV-2). The Neurosciences Journal of Shefaye Khatam. 2018;6:44.
  79. Ahmed-Farid O.A., Haredy S.A., Niazy R.M., Linhardt R.J., Warda M. Dose-dependent neuroprotective effect of oriental phyto-derived glycyrrhizin on experimental neuroterminal norepinephrine depletion in a rat brain model. Chemico-Biological Interactions. 2019;308:279-287.
  80. Kamboj P., Thakur A.K. Ameliorative potential of Glycyrrhiza glabra extracts on memory impairments in stress triggered rats. Current Traditional Medicine. 2021;7:108-117.
  81. Li X., Qin X., Tian J., Gao X., Wu X., Du G., Zhou Y. Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway. Food and Chemical Toxicology. 2020;146:111801.
  82. Ban J.Y., Park H.K., Kim S.K. Effect of glycyrrhizic acid on scopolamine-induced cognitive impairment in mice. International Neurology Journal. 2020;24:S48.
  83. Murugan S.K., Bethapudi B., Raghunandhakumar S., Purusothaman D., Nithyanantham M., Mundkinajeddu D., Talkad M.S. A flavonoid-rich standardised extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression. BMC complementary medicine and therapies. 2022;22:1-14.
  84. Rakshanda B., Shriniwas P. Glycyrrhiza glabra assisted green synthesis of metallic nanoparticles with different applications: A review, International Journal of Life Science Research Archive. 2023;4:36-39.
  85. Somaye H., Soghra M., Hossein H. The genus Glycyrrhiza (Fabaceae family) and its active constituents as protective agents against natural or chemical toxicities. Phytotherapy Research. 2021.
  86. Luo Z., Fu C., Li T., Gao Q., Miao D., Xu J., Zhao Y. Hypoglycemic effects of licochalcone A on the streptozotocin-induced diabetic mice and its mechanism study. Journal of Agricultural and Food Chemistry. 2021;69:2444-2456.
  87. Álvarez-Almazán S., Solís-Domínguez L.C., Duperou-Luna P., Fuerte-Gómez T., González-Andrade M., Aranda-Barradas M.E., Palacios-Espinosa J.F., Pérez-Villanueva J., Matadamas-Martínez F., Miranda-Castro S.P. Anti-diabetic activity of glycyrrhetinic acid derivatives FC-114 and FC-122: scale-up, in silico, in vitro, and in vivo studies. International Journal of Molecular Sciences. 2023;24:12812.
  88. Du J., Cao L., Jia R., Yin G. Hepatoprotective and antioxidant effects of dietary Glycyrrhiza polysaccharide against TCDD-induced hepatic injury and RT-PCR quantification of AHR2, ARNT2, CYP1A mRNA in Jian Carp (Cyprinus carpio var. Jian). Journal of Environmental Sciences. 2017;51:181-190.
  89. Karthikkeyan G., Prabhu A., Pervaje R., Pervaje S.K., Modi P.K., Prasad T.S.K. Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson’s disease model. Data in Brief. 2021;39:107535.
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سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب