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Bahrampour Juybari, Kobra, Mahmoudi, Mitra, Bayat, Sara, Noorian, Pouya, Rostami Ghadi, Foroogh, Goudarzi, Mehdi, Houshmand, Gholamreza. (1405). Gallic Acid Mitigates Carrageenan-Induced Acute Paw Edema in Rats through Antioxidant Activity and Modulation of NF-κB, COX-2, and Proinflammatory Cytokines. سامانه مدیریت نشریات علمی, 15(3), 376-382. doi: 10.22034/jmpb.2026.370818.2059
Kobra Bahrampour Juybari; Mitra Mahmoudi; Sara Bayat; Pouya Noorian; Foroogh Rostami Ghadi; Mehdi Goudarzi; Gholamreza Houshmand. "Gallic Acid Mitigates Carrageenan-Induced Acute Paw Edema in Rats through Antioxidant Activity and Modulation of NF-κB, COX-2, and Proinflammatory Cytokines". سامانه مدیریت نشریات علمی, 15, 3, 1405, 376-382. doi: 10.22034/jmpb.2026.370818.2059
Bahrampour Juybari, Kobra, Mahmoudi, Mitra, Bayat, Sara, Noorian, Pouya, Rostami Ghadi, Foroogh, Goudarzi, Mehdi, Houshmand, Gholamreza. (1405). 'Gallic Acid Mitigates Carrageenan-Induced Acute Paw Edema in Rats through Antioxidant Activity and Modulation of NF-κB, COX-2, and Proinflammatory Cytokines', سامانه مدیریت نشریات علمی, 15(3), pp. 376-382. doi: 10.22034/jmpb.2026.370818.2059
Bahrampour Juybari, Kobra, Mahmoudi, Mitra, Bayat, Sara, Noorian, Pouya, Rostami Ghadi, Foroogh, Goudarzi, Mehdi, Houshmand, Gholamreza. Gallic Acid Mitigates Carrageenan-Induced Acute Paw Edema in Rats through Antioxidant Activity and Modulation of NF-κB, COX-2, and Proinflammatory Cytokines. سامانه مدیریت نشریات علمی, 1405; 15(3): 376-382. doi: 10.22034/jmpb.2026.370818.2059

Gallic Acid Mitigates Carrageenan-Induced Acute Paw Edema in Rats through Antioxidant Activity and Modulation of NF-κB, COX-2, and Proinflammatory Cytokines

Journal of Medicinal plants and By-products
مقاله 10، دوره 15، شماره 3، مرداد و شهریور 2026، صفحه 376-382    اصل مقاله (833.92 K)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2026.370818.2059
نویسندگان
Kobra Bahrampour Juybari1، 2؛ Mitra Mahmoudi2؛ Sara Bayat3، 4؛ Pouya Noorian2؛ Foroogh Rostami Ghadi2؛ Mehdi Goudarzi5، 6؛ Gholamreza Houshmand* 7، 2
1Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2Department of pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran
5Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
This research project was conducted to assess the anti-inflammatory and antioxidant mechanisms of gallic acid (GA) in a rat model of paw edema triggered by carrageenan (Carr). In this experimental investigation, 42 adults male Wistar rats were casually sorted to make six experimental groups. Group I received normal saline (NS). Group II received NS before the Carr injection. Group III was treated with indomethacin (IND) prior to Carr injection. Groups IV-VI received GA at increasing doses before the Carr administration. By analyzing oxidative stress indicators, inflammatory signaling pathways, and serum cytokine levels, the regulating properties of GA on Carr-stimulated rat paw inflammation were ascertained. The levels of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), nuclear factor-kappa B (NF-κB), malondialdehyde, nitric oxide, and tumor necrosis factor α (TNF-α) were all meaningfully reduced by GA. Additionally, GA increased interleukin-10 secretions and enhanced the activation of glutathione peroxidase, catalase, and superoxide dismutase besides glutathione content. Gallic acid meaningfully reduced paw edema triggered via Carr injection in rats, indicating a robust acute anti-inflammatory effect. Moreover, it suppressed Carr-induced inflammation through its antioxidative properties.
کلیدواژه‌ها
Gallic acid؛ Carrageenan؛ Antioxidant؛ NF-κB؛ TNF-α
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