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Meta-analysis of Bovine Leptospirosis Prevalence in India | ||
| Archives of Razi Institute | ||
| مقاله 1، دوره 80، شماره 6، بهمن و اسفند 2025، صفحه 1353-1368 اصل مقاله (2.29 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.66224/ARI.80.6.3504 | ||
| نویسندگان | ||
| Kirubakaran Vinod Kumar1؛ Prajakta Prashant Bokade1؛ Rithu Lakshman2؛ Oviya Deenadayalan3؛ Shashikumar Sowjanyakumari1؛ Akshata Nayak4؛ Archana Pal1؛ Swathi M1؛ Arun Y P1؛ Kuralayanapalya Puttahonnappa Suresh1؛ Chandan Dharmashekar5؛ Chandan Shivamallu6؛ Vinayagamurthy Balamurugan* 1 | ||
| 1Indian Council of Agricultural Research -National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Karnataka, India. | ||
| 2Quarry Lane School, Dublin, United States. | ||
| 33. Lambert High School, Suwanee, United States. | ||
| 4Indian Council of Agricultural Research -National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560 064, Karnataka, India | ||
| 5Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India. | ||
| 6Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Karnataka, India. | ||
| چکیده | ||
| Leptospirosis is a globally significant and neglected zoonotic disease caused by pathogenic Leptospira spp., affecting a wide range of mammalian hosts including humans, cattle, and buffaloes. In livestock, it leads to considerable economic losses through abortions, stillbirths, reduced fertility, and decreased milk production, especially in tropical and subtropical regions where environmental conditions favor bacterial persistence and transmission. Despite its severity, bovine leptospirosis remains under reported in endemic regions such as India. This meta-analysis synthesized data from 46 studies (2001–2021) to estimate the pooled prevalence, epidemiology, and diagnostic challenges of bovine leptospirosis in India. The pooled prevalence was 29% in cattle and 32% in buffaloes. Seropositivity ranged from 50–70% in animals with reproductive disorders to 15–20% in healthy bovines. Coastal states such as Gujarat, Andhra Pradesh, Maharashtra, Tamil Nadu, Kerala, and the Andaman Islands showed the highest prevalence, influenced by favorable ecological conditions. Twenty pathogenic Leptospira serogroups were identified, with dominant serogroups (Sejroe, Icterohaemorrhagiae, Hebdomadis, Pomona, etc.) and evidence of temporal shifts in the prevalent serogroups. Significant diagnostic challenges included variability in sample sizes, heterogeneity among studies, and the limited sensitivity of enzyme-linked immunosorbent assay (ELISA) compared to the gold-standard microscopic agglutination test (MAT). These findings underscore the urgent need for enhanced surveillance, incorporation of diverse serogroups into diagnostic panels, and region-specific vaccination strategies. Strengthening molecular diagnostic tools, improving seroepidemiological studies, and implementing targeted control measures are essential for reducing the impact of leptospirosis on livestock productivity and public health in India. This work offers critical insights that can inform policy decisions and intervention strategies for effective disease management. | ||
| کلیدواژه‌ها | ||
| Bovine؛ Epidemiology؛ India؛ Leptospirosis؛ Meta-analysis؛ Perspectives | ||
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