Evaluation of the separate and combined effects of Prosopis farcta extract, olive oil, and omega-3 on serum lipid levels in hypercholesterolemic rats | ||
| تحقیقات دامپزشکی و فرآوردههای بیولوژیک | ||
| Article 3, Volume 39, Issue 2, July 2026, Pages 27-45 PDF (3.56 M) | ||
| Document Type: Full Research Paper | ||
| DOI: 10.22092/vj.2025.371250.2260 | ||
| Authors | ||
| Amirhosein Javanmard1; Namdar Yousofvand2; Mohammad Shamsollahi* 3; Farshid Fatahnia3 | ||
| 1Department of Biology, Faculty of Basic Sciences, Razi University, Kermanshah, Iran | ||
| 2Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran | ||
| 3Department of Animal Science, Faculty of Agriculture, Ilam University, Ilam, Iran | ||
| Abstract | ||
| Abstract Introduction: Although cholesterol is an essential and vital compound in the formation of cell membranes, high levels of cholesterol in the blood can act as a major risk factor. Prosopis farcta (P. farcta) is a leguminous plant that has been reported to possess many medicinal properties. Olive oil and omega-3 unsaturated fatty acids are highly beneficial and essential for the body.Objectives: This study was conducted to investigate the effects of P. farcta extract, alone and in combination with olive oil and omega-3, on plasma lipid levels in hypercholesterolemic rats.Methods: To conduct the experiment, 60 male Wistar rats were used and randomly divided into 10 groups, with 6 rats in each group. Group 1 served as the control group and received a normal diet. Group 2 served as the hypercholesterolemia group and received a high-fat diet (containing 2% cholesterol) for 8 weeks. Groups 3 to 10 were initially fed a high-fat diet for 4 weeks and then, for the following 4 weeks, continued on the high-fat diet while respectively receiving different treatments: 100 mg/kg of P. farcta extract, 5% olive oil, 400 mg/kg of omega-3, olive oil plus omega-3, P. farcta extract plus olive oil, P. farcta extract plus omega-3, P. farcta extract plus olive oil and omega-3, and 20 mg/kg of atorvastatin. At the end of the experiment, following blood collection, liver tissues and serum samples were sent to the laboratory for the measurement of blood parameters.Results: The results obtained from this study showed that feeding a high-fat diet increased body weight and plasma levels of total cholesterol, triglycerides, LDL, VLDL, glucose, and the liver enzyme aspartate aminotransferase. In addition, liver histopathological examination of animals in the hypercholesterolemia group revealed destructive structural changes, including fat accumulation in the form of macrovesicles and microvesicles, hepatocellular steatosis, cell swelling and ballooning, as well as hyperemia and inflammation in the central vein and sinusoids. Conclusion: Treatment with P. farcta extract, olive oil, and omega-3, either individually or in combination, was able to improve the above-mentioned changes and disorders. | ||
| Keywords | ||
| Omega-3; Prosopis farcta; Olive oil; Liver; Hypercholesterolemia | ||
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