Evaluation of the separate and combined effects of Prosopis farcta extract, olive oil, and omega-3 on serum lipid levels in hypercholesterolemic rats | ||
| تحقیقات دامپزشکی و فرآوردههای بیولوژیک | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 December 2025 | ||
| Document Type: Full Research Paper | ||
| DOI: 10.22092/vj.2025.371250.2260 | ||
| Authors | ||
| Amirhosein Javanmard1; Namdar Yousofvand2; mohammad shamsollahi* 3; Farshid Fatahnia4 | ||
| 1MSc. Graduated With a Master's degree in Animal Biology-Physiology, Department of Biology, Faculty of Basic Sciences, Razi University, Kermanshah, Iran | ||
| 2Associate professor, Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran | ||
| 3Department of Animal Science, Faculty of Agriculture, Ilam University, Ilam, Iran | ||
| 4Professor, Department of Animal Science, Faculty of Agriculture, Ilam University, Ilam, Iran | ||
| Abstract | ||
| Introduction: Although cholesterol is an essential and vital compound in the formation of cell membranes, its high amount in the blood can act as a high-risk factor in the body. Olives and omega-3 unsaturated fatty acids are very beneficial and essential for the body. Objectives: This study was conducted with the aim of investigating the effect of Prosopis farcta extract combined with olive oil and omega-3 on the plasma level of lipids in hypercholesterolemic rats. Methods: To conduct the experiment, 60 male Wistar rats were prepared and randomly divided into 10 groups with 6 replications. 1- Control group: Normal diet 2- Hypercholesterolemia group: High-fat diet (containing 2% cholesterol) for 8 weeks, groups 3 to 10 were initially given a high-fat diet for 4 weeks and then for 4 weeks along with a high-fat diet, respectively, 100 mg/kg of Prosopis farcta extract, 5% olive oil, 400 mg/kg of omega-3, olive oil + omega-3, fenugreek extract and olive oil, Prosopis farcta extract and omega-3, Prosopis farcta extract, olive oil and omega-3, and 20 mg/kg of atorvastatin. At the end of the experiment, after blood collection, liver tissue and serum samples were sent to the laboratory for measurement of blood parameters. Results: The results obtained from this study showed that feeding with a high-fat diet increased body weight, plasma levels of total cholesterol, triglycerides, LDL, VLDL, glucose and liver enzyme aspartate aminotransferase. Also, in the histopathological examination of the liver of hypercholesterolemic animals, destructive structural changes such as accumulation of fat in the form of macrovesicles and microvesicles, steatosis of hepatocytes, swelling and blistering of cells, and hyperemia and inflammation in the central vein and sinusoids were observed. Conclusion: Therefore, the use of the above substances and compounds in the treatment of complications caused by hypercholesterolemia can be useful and effective. | ||
| Keywords | ||
| Omega-3; Prosopis farcta; Olive oil; Liver; Hypercholesterolemia | ||
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