اخبار و اعلانات

 آمار

تعداد نشریات282
تعداد نشریات سازمان80
تعداد شماره‌ها3,168
تعداد مقالات35,197
تعداد مشاهده مقاله50,932,412
تعداد دریافت فایل اصل مقاله90,937,886
Hashemi Tayer, Akbar, Sotoodeh Jahromi, Abdolreza, Kamravan, Maryam, Ansari, Pegah. (1404). Inhibitory Effects of Crocin and Crocetin on Platelet Aggregation and Adhesion in Healthy Volunteers. سامانه مدیریت نشریات علمی, 15(2), 262-266. doi: 10.22034/jmpb.2025.368674.1905
Akbar Hashemi Tayer; Abdolreza Sotoodeh Jahromi; Maryam Kamravan; Pegah Ansari. "Inhibitory Effects of Crocin and Crocetin on Platelet Aggregation and Adhesion in Healthy Volunteers". سامانه مدیریت نشریات علمی, 15, 2, 1404, 262-266. doi: 10.22034/jmpb.2025.368674.1905
Hashemi Tayer, Akbar, Sotoodeh Jahromi, Abdolreza, Kamravan, Maryam, Ansari, Pegah. (1404). 'Inhibitory Effects of Crocin and Crocetin on Platelet Aggregation and Adhesion in Healthy Volunteers', سامانه مدیریت نشریات علمی, 15(2), pp. 262-266. doi: 10.22034/jmpb.2025.368674.1905
Hashemi Tayer, Akbar, Sotoodeh Jahromi, Abdolreza, Kamravan, Maryam, Ansari, Pegah. Inhibitory Effects of Crocin and Crocetin on Platelet Aggregation and Adhesion in Healthy Volunteers. سامانه مدیریت نشریات علمی, 1404; 15(2): 262-266. doi: 10.22034/jmpb.2025.368674.1905

Inhibitory Effects of Crocin and Crocetin on Platelet Aggregation and Adhesion in Healthy Volunteers

Journal of Medicinal plants and By-products
مقاله 16، دوره 15، شماره 2، فروردین و اردیبهشت 2026، صفحه 262-266    اصل مقاله (863.12 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.368674.1905
نویسندگان
Akbar Hashemi Tayer* 1؛ Abdolreza Sotoodeh Jahromi1؛ Maryam Kamravan1؛ Pegah Ansari2
1Research Center for Noncommunicable Diseases , Jahrom University of Medical Sciences, Jahrom, Iran
2Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
چکیده
Medicinal plants have shown potential in preventing cardiovascular diseases due to their bioactive compounds. This study evaluated the inhibitory effects of saffron-derived crocin and crocetin on platelet aggregation induced by various agonists and also their impact on platelet adhesion. This experimental laboratory study included 10 healthy individuals. Hemostasis was assessed using prothrombin time (PT) and partial thromboplastin time (PTT) tests, while complete blood count (CBC) analysis was performed with a Sysmex hematology analyzer. Platelet aggregation was evaluated in the presence of crocin and crocetin using a Chronolog dual-channel aggregometer with agonists including collagen, ADP, epinephrine, and calcium ionophore A23187. Platelet adhesion was also assessed using the Bellavite method and ELISA. Statistical analyses were performed with SPSS version 24 and GraphPad Prism version 8.  A p-value < 0.05 indicated statistical significance. The participants had an average age of 27.3 ± 3.4 years. PT, PTT, and CBC indices were within normal ranges. Both crocin and crocetin significantly inhibited platelet aggregation in a dose-dependent manner compared to the untreated group (p < 0.001). Platelet adhesion also decreased considerably at higher concentrations of crocin and crocetin (100 and 200 µg/mL) compared to the control group (p < 0.01). Crocin and crocetin, key bioactive compounds in saffron, demonstrated potent antiplatelet effects by inhibiting platelet aggregation and adhesion. These findings suggest that these compounds could prevent and potentially treat thrombotic disorders.
کلیدواژه‌ها
Crocin؛ Crocetin؛ Platelet Aggregation؛ Platelet Adhesion
مراجع
  1. Kaiser R., Escaig R., Nicolai L. Hemostasis without clot formation–how platelets guard the vasculature in inflammation, infection, and malignancy. Blood. 2023;142(17):1413-25.
  2. Han D., Sun W., Clark K.P., Griffith B.P., Wu Z.J. Investigation of the role of von Willebrand factor in shear‐induced platelet activation and functional alteration under high non‐physiological shear stress. Artificial Organs. 2024;48(5):514-24.
  3. Rendu F., Brohard-Bohn B. The platelet release reaction: granules' constituents, secretion and functions. Platelets. 2001;12(5):261-73.
  4. Ornelas A., Zacharias-Millward N., Menter D.G., Davis J.S., Lichtenberger L., Hawke D., Hawk E., Vilar E., Bhattacharya P., Millward S. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer and Metastasis Reviews. 2017;36(2):289-303.
  5. Chen Y., Ruggeri Z.M. Distinct platelet interactions with soluble and immobilized von Willebrand factor modulate platelet adhesion and aggregation with differential impact on hemostasis and thrombosis. bioRxiv. 2024:2024.01. 31.578078.
  6. Mandel J., Casari M., Stepanyan M., Martyanov A., Deppermann C. Beyond hemostasis: platelet innate immune interactions and thromboinflammation. International Journal of Molecular Sciences. 2022;23(7):3868.
  7. Hirsch G.E., Viecili P.R.N., de Almeida A.S., Nascimento S., Porto F.G., Otero J., Schmidt A., da Silva B., Parisi M.M., Klafke J.Z. Natural Products with Antiplatelet Action. Current Pharmaceutical Design. 2017;23(8):1228-46.
  8. Rengasamy K.R., Khan H., Ahmad I., Lobine D., Mahomoodally F., Suroowan S., Hassan S.T., Xu S., Patel S., Daglia M. Bioactive peptides and proteins as alternative antiplatelet drugs. Medicinal Research Reviews. 2019;39(6):2153-71.
  9. Boskabady M.H., Farkhondeh T. Antiinflammatory, antioxidant, and immunomodulatory effects of Crocus sativus L. and its main constituents. Phytotherapy Research. 2016;30(7):1072-94.
  10. El Midaoui A., Ghzaiel I., Vervandier-Fasseur D., Ksila M., Zarrouk A., Nury T., Khallouki F., El Hessni A., Ibrahimi S.O., Latruffe N. Saffron (Crocus sativus L.): A source of nutrients for health and for the treatment of neuropsychiatric and age-related diseases. Nutrients. 2022;14(3):597.
  11. Shakeri M., Hashemi Tayer A., Shakeri H., Sotoodeh Jahromi A., Moradzadeh M., Hojjat-Farsangi M. Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article. Asian Pacific Journal of Cancer Prevention. 2020;21(7):1867-75.
  12. Thushara R., Hemshekhar M., Santhosh M.S., Jnaneshwari S., Nayaka S., Naveen S., Kemparaju K., Girish K. Crocin, a dietary additive protects platelets from oxidative stress-induced apoptosis and inhibits platelet aggregation. Molecular and Cellular Biochemistry. 2013;373:73-83.
  13. Yang L., Qian Z., Yang Y., Sheng L., Ji H., Zhou C., Kazi H.A. Involvement of Ca2+ in the inhibition by crocetin of platelet activity and thrombosis formation. Journal of Agricultural and Food Chemistry. 2008;56(20):9429-33.
  14. Fakhar H., Hashemi Tayer A. Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time. Iranian Journal of Pediatric Hematology and Oncology. 2012;2(4):146-52.
  15. Thushara R.M., Hemshekhar M., Santhosh M.S., Jnaneshwari S., Nayaka S.C., Naveen S., Kemparaju K., Girish K.S. Crocin, a dietary additive protects platelets from oxidative stress-induced apoptosis and inhibits platelet aggregation. Molecular and Cellular Biochemistry. 2013;373(1-2):73-83.
  16. Guo Z.L., Li M.X., Li X.L., Wang P., Wang W.G., Du W.Z., Yang Z.Q., Chen S.F., Wu D., Tian X.Y. Crocetin: A Systematic Review. Front Pharmacol. 2021;12:745683.
  17. Nouruzi S., Vasheghani Farahani A., Rezaeizadeh H., Ghafouri P., Ghorashi S.M., Omidi N. Platelet Aggregation Inhibition: An Evidence-Based Systematic Review on the Role of Herbs for Primary Prevention Based on Randomized Controlled Trials. Iranian Journal of Medical Sciences. 2022;47(6):505-16.
  18. Mohamadi Yarijani Z., Pourmotabbed A., Pourmotabbed T., Najafi H. Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries. Iranian Journal of Basic Medical Sciences. 2017;20(7):753-59.
  19. Mohamadpour A.H., Ayati Z., Parizadeh M.R., Rajbai O., Hosseinzadeh H. Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers. Iranian Journal of Basic Medical Sciences. 2013;16(1):39-44.
  20. Yang L., Dong X. Inhibition of inflammatory response by crocin attenuates hemorrhagic shock-induced organ damages in rats. Journal of Interferon & Cytokine Research. 2017;37(7):295-302.
  21. Fälker K., Lange D., Presek P. ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets. Journal of Thrombosis and Haemostasis. 2004;92(1):114-23.
  22. Wang L., Wang J., Xu J., Qin W., Wang Y., Luo S., Wang G. The Role and Molecular Mechanism of P2Y12 Receptors in the Pathogenesis of Atherosclerotic Cardiovascular Diseases. Applied Sciences. 2021;11(19):9078.
  23. Laghaei N., Ghahramani M. The response of the coagulation system and fibrinolytic factors to exercise and saffron: A systematic review. [Review Article]. Journal of Basic Research in Medical Sciences. 2023;10(1):49-58.
  24. Khan A., Muhamad N.A., Ismail H., Nasir A., Khalil A.A.K., Anwar Y., Khan Z., Ali A., Taha R.M., Al-Shara B. Potential nutraceutical benefits of in vivo grown saffron (Crocus sativus L.) as analgesic, anti-inflammatory, anticoagulant, and antidepressant in mice. Plants. 2020;9(11):1414.
آمار
تعداد مشاهده مقاله: 342
تعداد دریافت فایل اصل مقاله: 178


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب