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Mirzaabolghasemi, Mohammad Amin, Pirmoradi, Mohammad Reza, Raghami, Mahmoud Reza, Martinelli, Tommaso. (1404). Silymarin Chemotype and Content in Wild Iranian Milk Thistle (Silybum marianum (L.) Gaertn.). سامانه مدیریت نشریات علمی, 15(2), 168-173. doi: 10.22034/jmpb.2025.369015.2008
Mohammad Amin Mirzaabolghasemi; Mohammad Reza Pirmoradi; Mahmoud Reza Raghami; Tommaso Martinelli. "Silymarin Chemotype and Content in Wild Iranian Milk Thistle (Silybum marianum (L.) Gaertn.)". سامانه مدیریت نشریات علمی, 15, 2, 1404, 168-173. doi: 10.22034/jmpb.2025.369015.2008
Mirzaabolghasemi, Mohammad Amin, Pirmoradi, Mohammad Reza, Raghami, Mahmoud Reza, Martinelli, Tommaso. (1404). 'Silymarin Chemotype and Content in Wild Iranian Milk Thistle (Silybum marianum (L.) Gaertn.)', سامانه مدیریت نشریات علمی, 15(2), pp. 168-173. doi: 10.22034/jmpb.2025.369015.2008
Mirzaabolghasemi, Mohammad Amin, Pirmoradi, Mohammad Reza, Raghami, Mahmoud Reza, Martinelli, Tommaso. Silymarin Chemotype and Content in Wild Iranian Milk Thistle (Silybum marianum (L.) Gaertn.). سامانه مدیریت نشریات علمی, 1404; 15(2): 168-173. doi: 10.22034/jmpb.2025.369015.2008

Silymarin Chemotype and Content in Wild Iranian Milk Thistle (Silybum marianum (L.) Gaertn.)

Journal of Medicinal plants and By-products
مقاله 2، دوره 15، شماره 2، فروردین و اردیبهشت 2026، صفحه 168-173    اصل مقاله (1.07 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.369015.2008
نویسندگان
Mohammad Amin Mirzaabolghasemi* 1؛ Mohammad Reza Pirmoradi1؛ Mahmoud Reza Raghami1؛ Tommaso Martinelli2
1Section of Plant Breeding and Biotechnology, Department of Horticulture, Faculty of Agriculture, Vali-e-Asr University of Rafsanjan, 7718897111, Rafsanjan, Iran
2Council for Agricultural Research and Economics, Research Centre for Plant Protection and Certification (CREA-DC), Loc. Cascine del Riccio, Via di Lanciola 12/A; 50125, Firenze, Italy
چکیده
Milk thistle (Silybum marianum) of the Asteraceae family is recognized as a valuable medicinal herb, primarily due to the presence of silymarin - a complex of flavonolignans concentrated in its fruits. Naturally occurring milk thistle populations can contain individuals of uniform chemotype or mixtures of multiple chemotypes, though only three (A, B, and C) have been documented so far. This research investigated the silymarin chemotype and content across 18 wild milk thistle populations gathered from various Iranian regions and cultivated under uniform environmental conditions. Eight populations were classified as chemotype B, while the remainder consisted of mixed chemotypes. The mean silymarin content was found to be 32.68 ± 2.46 mg/g dry weight, with population 23 exhibiting the highest level (47.94 mg/g) and population 21 the lowest (21.87 mg/g). Additionally, 16 individual plants from four heterogeneous populations were assessed, revealing the known chemotypes A, B, and C, and identifying a novel chemotype (designated E) for the first time. This finding highlights significant chemical diversity in Iranian milk thistle. Both A and B chemotypes were widespread, with no clear geographic pattern. Overall, these findings enrich the understanding of milk thistle chemodiversity and offer insights useful for breeding programs aimed at enhancing silymarin yield and quality.
کلیدواژه‌ها
Marian thistle؛ Silybin؛ Chemotyping؛ Chemotaxonomy؛ Phytochemical variation
مراجع
  1. Pignatti S. Flora d’Italia, Edagricole. 1982.
  2. Marceddu R., Dinolfo L., Carrubba A., Sarno M., Di Miceli G. Milk thistle (Silybum marianum L.) as a novel multipurpose crop for agriculture in marginal environments: A review. Agronomy. 2022;12(3):729-754. https://doi.org/10.3390/agronomy12030729.
  3. Gresta F., Avola G., Guarnaccia P. Agronomic characterization of some spontaneous genotypes of milk thistle (Silybum marianum L. Gaertn.) in Mediterranean environment. Journal of Herbs, Spices and Medicinal Plants. 2007;12(4):51-60. https://doi.org/10.1300/J044v12n04_05.
  4. Morazzoni P., Bombardelli E. Silybum marianum (Carduus marianus). Fitoterapia. 1995;66(1):3-42.
  5. Abenavoli L., Capasso R., Milic N., Capasso F. Milk thistle in liver diseases: past, present, future. Phytotherapy Research. 2010;24(10):1423-1432. https://doi.org/10.1002/ptr.3207.
  6. Polyak S.J., Morishima C., Lohmann V., Pal S., Lee D.Y., Liu Y., Oberlies N.H. Identification of hepatoprotective flavonolignans from silymarin. Proceedings of the National Academy of Sciences. 2010;107(13):5995-5999. https://doi.org/10.1073/pnas.0914009107.
  7. Andrew R., Izzo A.A. Principles of pharmacological research of nutraceuticals. British Journal of Pharmacology. 2017;174(11):1177. https://doi.org/10.1111/bph.13779.
  8. Giuliani C., Tani C., Bini L.M., Fico G., Colombo R., Martinelli T. Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. Fitoterapia. 2018;130(1):210-218. https://doi.org/10.1016/j.fitote.2018.09.002.
  9. Lee D.Y.W., Liu Y. Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, isolated from Silybum marianum (milk thistle). Journal of Natural Products. 2003;66(9):1171-1174. https://doi.org/10.1021/np030163b.
  10. Wang X., Zhang Z., Wu S.C. Health benefits of Silybum marianum: Phytochemistry, pharmacology, and applications. Journal of Agricultural and Food Chemistry. 2020;68(42):11644-11664. https://doi.org/10.1021/acs.jafc.0c04791.
  11. Shokrpour M., Mohammadi S.A., Moghaddam M., Ziai S.A., Javanshir A. Variation in flavonolignan concentration of milk thistle (Silybum marianum) fruits grown in Iran. Journal of Herbs, Spices and Medicinal Plants. 2008;13(4):55-69. https://doi.org/10.1080/10496470801946034.
  12. Martinelli T., Potenza E., Moschella A., Zaccheria F., Benedettelli S., Andrzejewska J. Phenotypic evaluation of a milk thistle germplasm collection: Fruit morphology and chemical composition. Crop Science. 2016;56(6):3160-3172. https://doi.org/10.2135/cropsci2016.03.0162.
  13. Martinelli T., Fulvio F., Pietrella M., Focacci M., Lauria M. Paris R. In Silybum marianum Italian wild populations the variability of silymarin profiles results from the combination of only two stable chemotypes. Fitoterapia. 2021;148(1):104797. https://doi.org/10.1016/j.fitote.2020.104797.
  14. Martinelli T., Whittaker A., Benedettelli S., Carboni A., Andrzejewska J. The study of flavonolignan association patterns in fruits of diverging Silybum marianum (L.) Gaertn. Chemotypes provides new insights into the silymarin biosynthetic pathway. Phytochemistry. 2017;144(1):9-18. https://doi.org/10.1016/j.phytochem.2017.08.013.
  15. Andrzejewska J., Sadowska K., Mielcarek S. Effect of sowing date and rate on the yield and flavonolignan content of the fruits of milk thistle (Silybum marianum L. Gaertn.) grown on light soil in a moderate climate. Industrial Crops and Products. 2011;33(2):462-468. https://doi.org/10.1016/j.indcrop.2010.10.027.
  16. Alemardan A., Karkanis A., Salehi R. Breeding objectives and selection criteria for milk thistle [Silybum marianum (L.) Gaertn.] improvement. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2013;41(2):340-347. https://doi.org/10.15835/nbha4129298.
  17. AbouZid S.F., Chen S.N., Pauli G.F. Silymarin content in Silybum marianum populations growing in Egypt. Industrial Crops and Products. 2016;83(1):729-737. https://doi.org/10.1016/j.indcrop.2015.12.012.
  18. AbouZid S.F., Ahmed H.S., Moawad A.S., Owis A.I., Chen S.N., Nachtergael A., McAlpine J.B., Brent Friesen J., Pauli, G.F. Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations. Fitoterapia. 2017;119(1):175-184. https://doi.org/10.1016/j.fitote.2017.04.002.
  19. Pasquariello M., Martinelli T., Paris R., Moschella A., Colombo R., Di Bello A., Frigerio J., Kheloufi A., Mirzaabolghasemi M.A., Puglisi D., Esposito S., Scalercio S., Virzì N., De Vita P., Pecchioni N., Bassolino L. Exploring the chemotypic variability of Silybum marianum and Silybum eburneum by biochemical and genetic characterization. Frontiers in Plant Science. 2025;16(1):1584104. https://doi.org/10.3389/fpls.2025.1584104.
  20. Martinelli T., Fulvio F., Pietrella M., Bassolino L., Paris R. Silybum marianum chemotype differentiation is genetically determined by factors involved in silydianin biosynthesis. Journal of Applied Research on Medicinal and Aromatic Plants. 2023;32(1):100442. https://doi.org/10.1016/j.jarmap.2022.100442.
  21. Arampatzis D.A., Karkanis A.C., Tsiropoulos N.G. Silymarin content and antioxidant activity of seeds of wild Silybum marianum populations growing in Greece. Annals of Applied Biology. 2019;174(1):61-73. https://doi.org/10.1111/aab.12470.
  22. Drouet S., Abbasi B.H., Falguières A., Ahmad W., Anjum S., Ferroud C., Doussot J., Vanier J.R., Lainé E., Hano C. Single laboratory validation of a quantitative core shell-based LC separation for the evaluation of silymarin variability and associated antioxidant activity of Pakistani ecotypes of milk thistle (Silybum marianum L.). Molecules. 2018;23(4):904-921. https://doi.org/10.3390/molecules23040904.
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