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Sewoyo, Palagan Senopati, Nainggolan, Willy Moris, Kardena, I Made, Winaya, Ida Bagus Oka, Gunawan, I Wayan Nico Fajar, Dewi, Ida Ayu Dian Kusuma. (1404). A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia. سامانه مدیریت نشریات علمی, 80(5), 1345-1352. doi: 10.32598/ARI.80.5.3808
Palagan Senopati Sewoyo; Willy Moris Nainggolan; I Made Kardena; Ida Bagus Oka Winaya; I Wayan Nico Fajar Gunawan; Ida Ayu Dian Kusuma Dewi. "A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia". سامانه مدیریت نشریات علمی, 80, 5, 1404, 1345-1352. doi: 10.32598/ARI.80.5.3808
Sewoyo, Palagan Senopati, Nainggolan, Willy Moris, Kardena, I Made, Winaya, Ida Bagus Oka, Gunawan, I Wayan Nico Fajar, Dewi, Ida Ayu Dian Kusuma. (1404). 'A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia', سامانه مدیریت نشریات علمی, 80(5), pp. 1345-1352. doi: 10.32598/ARI.80.5.3808
Sewoyo, Palagan Senopati, Nainggolan, Willy Moris, Kardena, I Made, Winaya, Ida Bagus Oka, Gunawan, I Wayan Nico Fajar, Dewi, Ida Ayu Dian Kusuma. A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia. سامانه مدیریت نشریات علمی, 1404; 80(5): 1345-1352. doi: 10.32598/ARI.80.5.3808

A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia

Archives of Razi Institute
مقاله 27، دوره 80، شماره 5، آذر و دی 2025، صفحه 1345-1352    اصل مقاله (2.65 M)
نوع مقاله: Case Study
شناسه دیجیتال (DOI): 10.32598/ARI.80.5.3808
نویسندگان
Palagan Senopati Sewoyo* 1؛ Willy Moris Nainggolan2؛ I Made Kardena1؛ Ida Bagus Oka Winaya1؛ I Wayan Nico Fajar Gunawan3؛ Ida Ayu Dian Kusuma Dewi3
1Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Udayana University, Bali, Indonesia.
2BVC Animal Hospital, Bali, Indonesia.
3Laboratory of Veterinary Clinical Diagnosis, Clinical Pathology, and Radiology, Faculty of Veterinary Medicine, Udayana University, Bali, Indonesia.
چکیده
Urothelial carcinoma is a malignant neoplasm of the urinary tract arising from the transitional epithelium. Its clinical manifestations often overlap with non-neoplastic conditions, such as urinary tract infections, thereby presenting a diagnostic challenge for clinicians. Differentiating from others condition is important, as the treatment and prognoses vary significantly. This case report presented a 4-year-old female local dog, weighing 11.55 kg in BVC Animal Hospital with a primary complaint of hematuria. Clinical, hematological, and serum biochemical evaluations revealed no significant abnormalities. Ultrasonographic (USG) examination identified a hypoechoic mass measuring 0.31×0.85 cm located within the lumen and thickening of urinary bladder wall. Cytological assessment was performed via urine catheterization. The cytological specimen demonstrated a population of cells with anisocytosis, anisokaryosis, and a high nucleus-to-cytoplasm ratio, raising suspicion of a malignant tumor. Consequently, biopsy was performed via cystotomy to establish a definitive diagnosis. Prior to release the histopathological results, post-cystotomy the dog was treated with cefadroxil as antibiotics at 20 mg/kg BW b.i.d for 14 days, carprofen as anti-inflammatory at 2 mg/kg BW s.i.d. for 5 days, and tramadol as analgesics at 2 mg/kg BW b.i.d. for 5 days. Histopathological examination showed a non-encapsulated tumor with well-defined demarcation in the mucosa. The tumor consists of a dense population of epithelial tumor cells without evidence of invasion, confirmed the diagnosis of non-invasive, non-papillary urothelial carcinoma (in situ). The patient was managed palliatively with the administration of piroxicam at 0.3 mg/kg BW s.i.d as monotherapy. Until day 190, the dog showing a stable disease. To the best of the authors’ knowledge, this is the first documented case of canine urothelial carcinoma in Indonesia
کلیدواژه‌ها
Bladder cancer؛ Dog؛ Palliative therapy؛ Transitional cell carcinoma
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مراجع

References

  1. Fulkerson CM, Knapp DW. Management of transitional cell carcinoma of the urinary bladder in dogs: A review. Vet J. 2015; ;205(2):217-25. [DOI:10.1016/j.tvjl.2015.01.017] [PMID]
  2. Shilpa VT, Girish BC, Nagaraju N, Ramya MN, Devi YS. A case of canine transitional cell carcinoma. Indian J Vet Pathol. 2019; 43:280-90. [DOI:10.5958/0973-970X.2019.00062.2]
  3. Griffin MA, Culp WT, Rebhun RB. Lower urinary tract neoplasia. Vet Sci. 2018; 5(4):96. [DOI:10.3390/vetsci5040096] [PMID]
  4. Shapiro SG, Raghunath S, Williams C, Motsinger-Reif AA, Cullen JM, Liu T, et al. Canine urothelial carcinoma: Genomically aberrant and comparatively relevant. Chromosome Res. 2015; 23(2):311-31. [DOI:10.1007/s10577-015-9471-y] [PMID]
  5. Plog S. Urogenital Tract Tumors. In: Klopfleisch R, editor. Veterinary Oncology. Cham: Springer; 2016. [DOI:10.1007/978-3-319-41124-8_7]
  6. de Sousa FG, da Cruz Neto JA, Beier SL, Chaves GG, Myrrha LW, Lopes H, et al. Biópsia por congelação para decisão terapêutica em Lhasa Apso com carcinoma urotelial. Med Vet. 2024; 18(4):300-9. [Link]
  7. Hamlin AN, Chadwick LE, Fox‐Alvarez SA, Hostnik ET. Ultrasound characteristics of feline urinary bladder transitional cell carcinoma are similar to canine urinary bladder transitional cell carcinoma. Vet Radiol Ultrasound. 2019; 60(5):552-9. [DOI:10.1111/vru.12777] [PMID]
  8. Norris AM, Laing EJ, Valli VEO, Withrow SJ, Macy DW, Ogilvie GK, et al. Canine Bladder and Urethral Tumors: A Retrospective Study of 115 Cases (1980-1985). J Vet Intern Med. 1992; 6(3):145-54. [DOI:10.1111/j.1939-1676.1992.tb00330.x] [PMID]
  9. Burgess KE, DeRegis CJ. Urologic oncology. Vet Clin North Am Small Anim Pract. 2019; 49(2):311-23. [DOI:10.1016/j.cvsm.2018.11.006] [PMID]
  10. Lee J, Choi US, Kwon M, Yoon H. Methodological evaluation of ultrasound-guided modified traumatic catheterization in dogs with suspected urothelial carcinoma. J Vet Sci. 2025; 26(3):e32. [DOI:10.4142/jvs.24308] [PMID]
  11. Shih DH, Shih PL, Wu TW, Lee CX, Shih MH. Distinguishing bladder cancer from cystitis patients using deep learning. Mathematics. 2023; 11(19):4118. [DOI:10.3390/math11194118]
  12. Mutsaers AJ, Widmer WR, Knapp DW. Canine transitional cell carcinoma. J Vet Intern Med. 2003; 17(2):136-44. [DOI:10.1892/0891-6640(2003)017<0136:ctcc>2.3.co;2] [PMID]
  13. Meuten DJ. Tumor in domestic animals. New Jersey: John Wiley & Sons; 2017. [DOI:10.1002/9781119181200]
  14. Knapp DW, Ramos-Vara JA, Moore GE, Dhawan D, Bonney PL, Young KE. Urinary bladder cancer in dogs, a naturally occurring model for cancer biology and drug development. ILAR J. 2014; 55(1):100-18. [DOI:10.1093/ilar/ilu018] [PMID]
  15. Henry CJ, McCaw DL, Turnquist SE, Tyler JW, Bravo L, Sheafor S, et al. Clinical evaluation of mitoxantrone and piroxicam in a canine model of human invasive urinary bladder carcinoma. Clin Cancer Res. 2003; 9(2):906-11. [PMID]
  16. Öztürk H, Egeden E, Egeden Ö, Gürel A. In-Situ Transitional Cell Carcinoma of Urinary Bladder in a Cat. Int J Vet Anim Res. 2018; 1(1):26-9. [Link]
  17. Caswell M. Transitional cell carcinoma of the urinary bladder in a 14-year-old dog. Can Vet J. 2011; 52(6):673-5. [PMID]
  18. Rasteiro AM, Sá e Lemos E, Oliveira PA, Gil da Costa RM. Molecular markers in urinary bladder cancer: Applications for diagnosis, prognosis and therapy. Vet Sci. 2022; 9(3):107. [DOI:10.3390/vetsci9030107] [PMID]
  19. Nagata M. A case of canine bladder transitional cell carcinoma treated with urethrocystectomy followed by total vaginectomy. J Jpn Vet Cancer Soc. 2024; 13(2):20-4. [DOI:10.12951/jvcs.2021-013]
  20. Ghisoni G, Foglia A, Sabattini S, Agnoli C, Dondi F, Perfetti S, et al. A retrospective clinico-pathologic study of 35 dogs with urethral transitional cell carcinoma undergoing treatment. Animals (Basel) 2023; 13(4):2395. [DOI:10.3390/ani13142395] [PMID]
  21. Knapp DW, Richardson RC, Chan TC, Bottoms GD, Widmer WR, DeNicola DB, et al. Piroxicam therapy in 34 dogs with transitional cell carcinoma of the urinary bladder. J Vet Intern Med. 1994; 8(4):273-8. [DOI:10.1111/j.1939-1676.1994.tb03232.x] [PMID]
  22. Suwankanit K, Manee-in S. Treatment of transitional cell carcinoma of urinary bladder using meloxicam in a dog: A case report. J ApplAnim Sci. 2018 1; 11(2):45-56. [Link]
  23. Chu KT, Nekouei O, Giuliano A. Treatment outcomes of dogs with transitional cell carcinoma. Front Vet Sci. 2025; 12:1486786. [DOI:10.3389/fvets.2025.1486786] [PMID]
  24. Beristain-Ruiz DM, Rodríguez-Alarcón CA, Pérez-Casio F, Itzá-Ortíz M, Rivera-Barreno R. Transitional cell carcinoma in the distal urethra of a female Golden Retriever. Acta SciVet. 2015; 43(Suppl 1):81. [Link]
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